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A novel clustered SPIO nanoplatform with enhanced magnetic resonance t2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

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Nano Research 2020年第8期13卷 2216-2225页

作者： Hongwei Lu Yongjing Xu Ruirui Qiao Ziwei Lu Pin Wang Xindan Zhang An Chen Liming Zou Zhongling Wang Department of Radiology Shanghai General HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai200080China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China ARC Centre of Excellence in Convergent Bio-Nano Science and technology Monash Institute of Pharmaceutical SciencesMonash University381 Royal ParadeParkvilleVIC3052Australia Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Gastroenterology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing210029China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer.Herein,we reported a novel super-paramagnetic iron oxide(SPIO)based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic purpose.this polyethylene glycol with four phenylboronic acid(PEG-B4)/CNts@porphyrin(ph)/SPIO(BCPS)nanoplatform was simply prepared via integrated SPIO,ph,and a novel dendrimer with PEG liner and four PBA groups(PEG-B4)on the surface of carbon nanotubes(CNts).Subsequently,a significant t2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO clustering.Moreover,the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer therapy.Furthermore,the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from PEG-B4.We showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor(1 mm)in the liver,but also effectively ablate tumors in a xenograft model,thereby achieving a complete cure rate of 100%at low laser dose.Our results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.

关键词： theranostic agent clustered SPIO nanoplatform t2 mri micro-tumor detection photothermal therapy synergetic effect

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