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Prospects of diagnostic and prognostic biomarkers of pyometra in canine

Asian pacific Journal of Reproduction 2020年第4期9卷 166-173页

作者： Laishram Kipjen Singh Manas Kumar Patra Girish Kumar Mishra Abhishek Chandra Saxena Ujjwal Kumar De Sanjay Kumar Singh Harendra Kumar Krishnaswamy Narayanan Animal Reproduction Division Indian Veterinary Research InstituteIzatnagarU.P.243122India Animal Reproduction Gynaecology and Obstetrics Division ICAR-National Dairy Research InstituteKarnal-132001India Department of Veterinary Gynaecology andObstetrics College of Veterinary Sciences and Animal HusbandryAnjoraDurg(C.G.)India Referral Veterinary Polyclinic ICAR-Indian Veterinary Research InstituteIzatnagarU.P.243122India ICAR-Indian Veterinary Reseach Institute HebbalBangaluru 560024India

Pyometra is one of the most common uterine pathologies of intact bitch at middle to advanced age. In the early stages, the disease shows subtle changes, making diagnosis a challenge. In contrast, at later stages, it manifests as potentially life-threatening Systemic inflammatory response syndrome. Ultrasonographic examination of the uterus aids in the diagnosis, although it has limitation in ascertaining the clinical severity of pyometra. Moreover, differentiation of cystic endometrial hyperplasia from pyometra could not be discerned with greater accuracy. Therefore, false negative diagnosis of pyometra patients leads to development of Systemic inflammatory response, which delays administration of therapies and results in deaths during early course of treatment. Further, indiscriminate use of broad-spectrum antimicrobials at higher dose in false positive cases considerably contributes to the rising pool of drug resistant pathogens, thereby increasing the risk of case fatality due to sepsis in a long-term. Monitoring the circulating pro-inflammatory cytokines, acute phase proteins, endotoxin, growth factors and inflammatory mediators is the current trend in pyometra research, especially for developing diagnostic and prognostic biomarkers. The present review deals with the prospects of developing diagnostic and prognostic biomarkers in the canine pyometra.

关键词： Pyometra Systemic inflammatory response Acute-phase proteins Prostaglandin F metabolite Canine

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Mean platelet volume as a novel predictor of systematic inflammatory response in cirrhotic patients with culturenegative neutrocytic ascites

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World Journal of Hepatology 2015年第7期7卷 1001-1006页

作者： Marisol Galvez-Martinez Alfredo I Servin-Caamano Eduardo Perez-Torres Francisco Salas-Gordillo Xaira Rivera-Gutierrez Fatima Higuera-de la Tijera Gastroenterology Department Hospital General de México "Dr. Eduardo Liceaga" Internal Medicine Department Hospital General de México "Dr. Eduardo Liceaga" Faculty of Medicine "Universidad Veracruzana"

AIM: To identify a mean platelet volume(MPV) cutoff value which should be able to predict the presence of bacterial infection.METHODS: An observational, analytic, retrospective study. We evaluated medical records of cirrhotic patients who were hospitalized from January 2012 to January 2014 at the Gastroenterology Department of "Hospital General de México Dr. Eduardo Liceaga", we included 51 cirrhotic patients with ascites fluid infection(AFI), and 50 non-infected cirrhotic patients as control group. Receiver operator characteristic curves were used to identify the best cutoff value of several parameters from hematic cytometry, including MPV, to predict the presence of ascites fluid infection.RESULTS: Of the 51 cases with AFI, 48 patients(94.1%) had culture-negative neutrocytic ascites(CNNA), 2(3.9%) had bacterial ascites, and one(2%)had spontaneous bacterial peritonitis. Infected patients had greater count of leucocytes and polymorphonuclear cells, greater levels of MPV and cardiac frequency(P 0.80). A cutoff MPV value of 8.3 fl was the best to discriminate between cirrhotic patients with AFI and those without infection. CONCLUSION: Our results support that MPV can be an useful predictor of Systemic inflammatory response syndrome in cirrhotic patients with AFI, particularly CNNA.

关键词： Mean platelet volume Cirrhosis Ascites fluid infection Culture negative neutrocytic ascites Systemic inflammatory response

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