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Non-pulmonary involvement in COVID-19:A systemic disease rather than a pure respiratory infection

World Journal of Clinical Cases 2023年第3期11卷 493-505页

作者： Mohamed El-Kassas Mohamed Alboraie Mohamed Elbadry Reem El Sheemy Mohamed Abdellah Shimaa Afify Ahmad Madkour Mariam Zaghloul Abeer Awad Mohamed-Naguib Wifi Amira Al Balakosy Mohamed Eltabbakh Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11731Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11884Egypt Department of Tropical Medicine Minia Faculty of MedicineMinia UniversityMinia 61511Egypt Department of Gastroenterology National Hepatology and Tropical Medicine Research InstituteCairo 11451Egypt Department of Hepatology Gastroenterology and Infectious DiseasesFaculty of MedicineKafrelsheikh UniversityKafrelsheikh 33511Egypt Department of Internal Medicine Hepatogastroenterology UnitKasr Al-Ainy School of MedicineCairo 11451Egypt Department of Tropical Medicine Ain Shams UniversityCairo 11451Egypt

During the early phase of the coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),diagnosis was difficult due to the diversity in symptoms and imaging findings and the variability of disease *** manifestations are reportedly the main clinical presentations of COVID-19 *** are working hard on a myriad of clinical,epidemiological,and biological aspects to better understand SARS-CoV-2 infection,aiming to mitigate the ongoing *** reports have documented the involvement of various body systems and organs apart from the respiratory tract including the gastrointestinal,liver,immune system,renal,and neurological *** involvement will result in diverse presentations related to effects on these *** presentations such as coagulation defects and cutaneous manifestation may also *** with specific comorbidities including obesity,diabetes,and hypertension have increased morbidity and mortality risks with COVID-19.

关键词： COVID-19 Non-pulmonary Extrapulmonary Clinical manifestations systemic disease

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Liver in systemic disease

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World Journal of Gastroenterology 2008年第26期14卷 4111-4119页

作者： Yukihiro Shimizu Division of Internal Medicine Center for Gastroenterology and HepatologyKyoto Katsura Hospital17 Yamada-HiraoNishikyoKyoto 615-8256Japan

Potential causes of abnormal liver function tests include viral hepatitis,alcohol intake,nonalcoholic fatty liver disease,autoimmune liver diseases,hereditary diseases,hepatobiliary malignancies or infection,gallstones and drug-induced liver ***,the liver may be involved in systemic diseases that mainly affect other ***,in patients without etiology of liver injury by screening serology and diagnostic imaging,but who have systemic diseases,the abnormal liver function test results might be caused by the systemic *** most of these patients,the systemic disease should be treated ***,some patients with systemic disease and severe liver injury or fulminant hepatic failure require intensive treatments of the liver.

关键词： Abnormal liver function tests Jaundice systemic disease

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Assessment of Knowledge of the Relationship between Periodontal disease and systemic disease among Dental Students and Its Impact on Oral Hygiene Practices

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Open Journal of Stomatology 2022年第1期12卷 10-19页

作者： Grace Onyenashia Alade Efetobo Victor Orikpete Department of Preventive and Social Dentistry University of Port Harcourt Port Harcourt Rivers State Nigeria Department of Oral Pathology and Oral Biology University of Port Harcourt Port Harcourt Rivers State Nigeria

Background: Dental students play a role in both oral and general health education in their communities, so it is important that they have good knowledge to enable them offer good counsel. Knowing the relationship between periodontal disease and systemic conditions will put them in better stead when giving oral health education. The aim of this study was to assess the level of knowledge among dental students of the relationship between periodontal diseases and systemic conditions, and to determine whether there was a correlation between this knowledge and their oral hygiene practices. Methods: This was a cross-sectional study among dental students of the University of Port Harcourt, Rivers State, Nigeria. Consenting participants were given a self-administered questionnaire eliciting socio-demographic information, knowledge about the relationship between periodontal diseases and systemic diseases, as well as oral hygiene practices. Each correct response on knowledge was scored as 1, while incorrect responses were scored 0, with a maximum score of 7. Participants’ knowledge was graded as poor (0 - 2), fair (3 - 5) and good (6 - 7). Data was analyzed using IBM SPSS version 21. p ≤ 0.05 was considered statistically significant. Spearman’s ranked correlation was used to assess the correlation between knowledge of the relationship between periodontal diseases and systemic diseases and oral hygiene practices. Results: There were 109 dental students (58 males, 51 females) in this study, with a mean age of 24.1 ± 3.6 years. Preclinical students were 43 (39.4%) while clinical students were 66 (60.6%). All (100%) participants knew that oral health was important to systemic health, with 89.9% knowing that periodontal disease was specifically linked to systemic disease. Only 50.5% of participants knew that there was a link between periodontal disease and diabetes mellitus. Sixty-four (58.7%) of the participants regularly cleaned

关键词： Periodontal disease systemic disease Oral Hygiene Practices Dental Students

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Glymphatic system:a gateway for neuroinflammation

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Neural Regeneration Research 2024年第12期19卷 2661-2672页

作者： Kailu Zou Qingwei Deng Hong Zhang Changsheng Huang Department of Anesthesiology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Xiangya School of Medicine Central South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

The glymphatic system is a relatively recently identified fluid exchange and transpo rt system in the *** evidence indicates thatglymphatic function is impaired not only in central nervous system disorders but also in systemic *** diseases can trigger the inflammatory responses in the central nervous system,occasionally leading to sustained inflammation and functional disturbance of the central nervous *** review summarizes the current knowledge on the association between glymphatic dysfunction and central nervous system *** addition,we discuss the hypothesis that disease conditions initially associated with peripheral inflammation ove rwhelm the performance of the glymphatic system,thereby triggering central nervous system dysfun ction,chronic neuroinflammation,and *** research investigating the role of the glymphatic system in neuroinflammation may offer innovative therapeutic approaches for central nervous system disorders.

关键词： aquaporin-4 central nervous system disease cerebrospinal fluid chronic neuroinflammation glymphatic dysfunction neurodegeneration peripheral nerve injury perivascular space systemic disease vicious cycle

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Prevalence of pseudoexfoliation syndrome and its association with ocular and systemic diseases in Eskisehir,Turkey

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 128-134页

作者： Nilgun Yildirim Erdogan Yasar Huseyin Gursoy Ertugrul Colak Department of Ophthalmology Eskisehir Osmangazi University Medical FacultyEskisehir 26180Turkey Department of Biostatistics Eskisehir Osmangazi University Medical FacultyEskisehir 26180Turkey

AIM： To investigate the prevalence of pseudoexfoliation syndrome （PEX） and its associations with ocular and systemic diseases in a population sample aged over 40y. METHODS： A total of 2356 subjects were randomly chosen for the sample population based on the database of the Turkish Statistical Agency in Eskisehir. Of the invited 2356 subjects, 2017 subjects participated, out of which 2009 were eligible for the study. systemic diseases, drug use, smoking and body mass index were assessed using questionnaires. Measurements of central corneal thickness （CCT）, anterior chamber depth （ACD） and intraocular pressure （IOP） were performed during June to December, 2015. After pupillary dilation, the anterior segment and lenses were evaluated using a slit ***： Prevalence of PEX in this sample was 5.0% （n=100）. Of patients with PEX, 26% also had glaucoma. Incidence of cataracts, and using drugs for hypertension, cardiac and psychiatric conditions was higher in patients with PEX compared to normal cases （P〈0.05）. Hearing loss was more common in PEX cases （34.0% vs 5.4%; P〈0.001）. The mean CCT, ACD and IOP were not significantly different between PEX and non-PEX ***： This study is the first population-based, randomized trial in Turkey. Prevalence of PEX in patients over 40 years old was found to be 5.0%. Besides glaucoma and cataract, hypertension, hearing loss, using drugs for cardiac and psychiatric diseases were associated with PEX.

关键词： pseudoexfoliation syndrome pseudoexfoliation glaucoma prevalence of pseudoexfoliation systemic disease Turkey

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Current status and future prospects of stomatology research

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第10期24卷 853-867,I0001页

作者： Qianming CHEN Yahui WANG Jing SHUAI Stomatology Hospital School of StomatologyZhejiang University School of MedicineClinical Research Center for Oral Diseases of Zhejiang ProvinceKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310006China

Research in stomatology(dental medicine)continues to expand globally and is oriented towards solving clinical issues,focusing on clarifying the clinical relevance and potential mechanisms of oral–systemic connections via clinical epidemiology,oral microecological characterization,and the establishment of animal *** integration of materials science and tissue engineering with stomatology is expected to lead to the creation of innovative materials and technologies to better resolve the most prevalent and challenging clinical issues such as peri-implantitis,soft and hard tissue defects,and dentin *** the rapid development of artificial intelligence(AI),5th generation mobile communication technology(5G),and big data applications,“intelligent stomatology”is emerging to build models for better clinical diagnosis and management,accelerate the reform of education,and support the growth and advancement of scientific ***,we summarized the current research status,and listed the future prospects and limitations of these three aspects,aiming to provide a basis for more accurate etiological exploration,novel treatment methods,and abundant big data analysis in stomatology to promote the translation of research achievements into practical applications for both clinicians and the public.

关键词： Stomatology Dental medicine systemic disease Material Innovative technique

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Effect of Periodontal Pathogens on Total Bone Volume Fraction:A Phenotypic Study

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Current Medical Science 2020年第4期40卷 753-760页

作者： Zai-yu ZHANG Meng-ru XIE Yi LIU Yao-xu LI Ke WU Yu-mei DING Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Stomatology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Summary:Studies have shown that periodontal pathogens can enter the bloodstream,causing a series of reactions that can lead to a variety of systemic *** investigations also found a tight correlation between periodontitis(PD)and *** study aimed to further explore the effect of periodontal pathogens on bone volume fraction like bone tissue and mass,and explain the relationship between PD and *** Dawley rats(female,16 weeks old)were divided into the wild-type(WT)control group(m=9)and PD group(n=9).After eight weeks,periodontal tissues and ligatures,the fourth lumbar vertebra,the femur,the tibia,and blood were extracted and analyzed by micro-computed tomography(micro-CT),hematoxylin and eosin(H&E)staining,tartrate-resistant acid phosphatase(TRAP)staining,polymerase chain reaction(PCR),and enzyme-linked immunoassay(ELISA),*** found that the bone mass of the lumbar vertebra,femur,and tibia was decreased in the PD *** number of osteoclasts was higher in bone tissue in the PD group than in the WT group(P0.05).In addition,we detected several periodontal pathogens,such as Porphyromonas gingivalis,Actinobacillus actinomycetemcomitans,and Fusobacterium nucleatum,in blood samples from rats in the PD *** findings suggest that periodontal pathogens can enter the blood circulation from periodontal tissue,promote a systemic inflammation response,and subsequently reduce systemic bone density.

关键词： periodontitis periodontal pathogens bone mineral density inflammation systemic disease

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Infrequent organ involvement in immunoglobulin G4-related prostate disease: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7485-7491页

作者： Yi Yu Qian-Qian Wang Li Jian Deng-Can Yang Department of Critical Care Medicine Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Pulmonary and Critical Care Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Critical Care Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Anesthesiology Department The Central Hospital of ShaoyangShaoyang 422000Hunan ProvinceChina

BACKGROUND Immunoglobulin G4-related prostate disease(IgG4-RPD)characterized by a high count of IgG4-positive plasma cells has distinctive serological and radiological *** we report a case of a patient who was successfully treated for IgG4-RPD,which manifested as frequent micturition,dysuric,and systemic *** SUMMARY The patient was a 33-year-old man who was referred to our hospital because of urinary tract symptoms that had persisted for 4 years.A physical examination revealed systemic lymphadenopathy and blood tests showed hyperglobulinemia with an IgG level of 18.90 g/L and an IgG4 level of 18.40 g/*** tomography(CT)revealed bilateral lacrimal gland,right parotid gland and prostatic *** on these findings,IgG4-RD was suspected,and further pathological examination and follow-up results showed expected ***,the patient was diagnosed with IgG4-RPD based on clinical symptoms,pathological examination,therapeutic effects,and follow-up *** received 50 mg oral prednisolone(the dose was gradually reduced and a low dose was used for long-term maintenance)in combination with cyclophosphamide 1.0 g via an intravenous drip for 6 *** year after the treatment was initiated,he was free of urinary or other complaints and his serum IgG4 level *** In IgG4-RPD with severe urinary tract symptoms,radiological findings should be carefully ***4-RPD prognosis is good because the disease responds well to ***,it is urgent for clinicians and pathologists to improve their understanding of IgG4-RPD.

关键词： Immunoglobulin G4-related prostate disease Infrequent organ involvement systemic disease Pathological examination Glucocorticoids Case report

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