Effect of Periodontal Pathogens on Total Bone Volume Fraction:A Phenotypic Study
作者机构：Department of StomatologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of StomatologyThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Gastrointestinal SurgeryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2020年第40卷第4期
页 面：753-760页
核心收录：
学科分类：1003[医学-口腔医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：This study was supported by the Natural Science Foundation of Hubei Province(No.2017CFB251)
主 题：periodontitis periodontal pathogens bone mineral density inflammation systemic disease
摘 要：Summary:Studies have shown that periodontal pathogens can enter the bloodstream,causing a series of reactions that can lead to a variety of systemic *** investigations also found a tight correlation between periodontitis(PD)and *** study aimed to further explore the effect of periodontal pathogens on bone volume fraction like bone tissue and mass,and explain the relationship between PD and *** Dawley rats(female,16 weeks old)were divided into the wild-type(WT)control group(m=9)and PD group(n=9).After eight weeks,periodontal tissues and ligatures,the fourth lumbar vertebra,the femur,the tibia,and blood were extracted and analyzed by micro-computed tomography(micro-CT),hematoxylin and eosin(H&E)staining,tartrate-resistant acid phosphatase(TRAP)staining,polymerase chain reaction(PCR),and enzyme-linked immunoassay(ELISA),*** found that the bone mass of the lumbar vertebra,femur,and tibia was decreased in the PD *** number of osteoclasts was higher in bone tissue in the PD group than in the WT group(P0.05).In addition,we detected several periodontal pathogens,such as Porphyromonas gingivalis,Actinobacillus actinomycetemcomitans,and Fusobacterium nucleatum,in blood samples from rats in the PD *** findings suggest that periodontal pathogens can enter the blood circulation from periodontal tissue,promote a systemic inflammation response,and subsequently reduce systemic bone density.
维普期刊数据库