检索结果-南通市图书馆

Chinese Medicine Prolongs Overall survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and survival analysis of a 20-Year Real-World Study

引用

Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONG Jia-huan QIN Meng-meng LIU Tian-shu ZHU Chun-chao GUO Wei-jian DING Hong-hua GUO Yuan-biao LIU Li-kun SONG Jin-jie WU Ji-ping CHENG Yue-lei ZENG Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in China between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(P<0.001).Conclusions In real-world practice for AGC in China,therapy choices consisted with ***-drug regimen was the main first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy evaluation and survival analysis of the combination of oxaliplatin plus Teysuno (SOX) with immune checkpoint inhibitors in the conversion therapy of locally advanced gastric cancer

引用

Oncology and Translational Medicine 2024年第4期10卷 190-197页

作者： Shuai Liu Kai Zhang Xiaoqing Zhang Wei Luan Inner Mongolia Medical University Graduate School Urumchi 010000China The Inner Mongolia autonomous region people's hospital and oncology Urumchi 010000China

Background:The efficacy of combining immune checkpoint inhibitors(ICIs)with chemotherapy in neoadjuvant therapy for locally advanced gastric cancer has been ***,limited research exists on its effectiveness in conversion therapy,and its superiority over standalone chemotherapy remains to be *** study aims to investigate the efficacy and survival outcomes of patients treated with ICIs in combination with conversion therapy for locally advanced gastric ***:Retrospective data from patients with locally advanced gastric cancer treated with either oxaliplatin+S-1(SOX)alone or in combination with ICIs in conversion therapywere *** andpathological characteristics,disease-free survival,andefficacy assessments in nonoperable patients were compared between the 2 treatment *** was further evaluated through dynamic changes in serum markers,and patients’quality of life was assessed using the QLQ-STO22(Gastric Cancer–Specific Quality of Life Questionnaire)quality-of-life measurement ***:A total of 140 patients underwent conversion therapy:80 in the SOX alone group and 60 in the SOX combined with the ICIs *** were no significant differences in baseline characteristics between the 2 *** with the SOX alone group,the SOX combined with ICIs group exhibited a higher conversion rate(83.3%vs 75%,P=0.23),R0 resection rate(90.0%vs 83.3%,P=0.31),pathological complete response(pCR)rate(18%vs 5%,P=0.02),median disease-free survival(21.4 vs 16.9 months,P=0.007),the objective response rate in nonoperable patients(60%vs 40%,P=0.301),and median progression-free survival time(7.9 vs 5.7 months,P=0.009).The QLQ-STO22 quality-of-life assessment revealed statistically significant improvements in pain,swallowing difficulties,and dietary restrictions in the combination therapy group compared with those in the monotherapy *** enhanced efficacy of immune combination with SOX is evident,as demonstrated by the

关键词： Conversion therapy Locally advanced gastric cancer Immune checkpoint inhibitors Gastrectomy Efficacy evaluation survival analysis Quality-of-life measurement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

survival analysis of car travel time near a bus stop in developing countries

引用

Science China(Technological Sciences) 2012年第8期55卷 2355-2361页

作者： YANG XiaoBao GAO ZiYou GUO HongWei HUAN Mei MOE Key Laboratory for Urban Transportation Complex Systems Theory and Technology Beijing Jiaotong UniversityBeijing 100044China Department of Transportation Engineering Beijing Institute of TechnologyBeijing 100081China

This paper presents an important investigation into car travel time affected by mixed traffic flow near a bus stop on the basis of survival analysis *** time data associated with mixed traffic characteristics near a bus stop were collected by video cameras.A hazard-based duration model was introduced to analyze the effects of mixed traffic flow on car travel *** results indicate that mixed traffic flow impacts car travel time *** the presence of bus berthing violation would delay car travel *** proposed model can be used to forecast temporal shifts in car travel time due to changes in mixed traffic *** influential factors related to mixed traffic flow should be given full consideration in the planning and designing of bus stops in developing countries.

关键词： survival analysis travel time duration model bus stop mixed traffic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

survival analysis following early surgical success in intermittent exotropia surgery

引用

International Journal of Ophthalmology(English edition) 2014年第3期7卷 528-533页

作者： Joo Yeon Lee Sung Ju Ko Sung Uk Baek Department of Ophthalmology Hallym University College of Medicine

AIM:To assess the consecutive recurrence following early success of intermittent exotropia surgery and to determine the clinical factors that affect the ***:One hundred and thirty-five patients who underwent intermittent exotropia surgery and experienced early surgical success[≤5 prism diopters(PD)esophoria(E)to≤10 PD exophoria(X)on the postoperative sixth month]were enrolled in this *** consecutive survival on the postoperative first year,second year and third year and at the last visit of fourth year or more,and the factors that might affect their survival,were *** final surgical outcomes after the postoperative fourth year were also investigated by dividing the patients into the success group(≤5 PD E to≤10 PD X)and the failure group(>5 PD esodeviation or>10 PD exodeviation)RESULTS:The survival rates from the Kaplan-Meier analysis were 97.78%,92.89%,83.70%and 50.49%on the postoperative first,second and third years and fourth year or more,*** of the clinical factors was determined to have affected the *** amount of the exodrift was largest(2.29 PD)between the first year and the second year,and smallest(1.47 PD)between the fourth year and the last ***-three patients had their final visit after the postoperative fourth year,and 29 of them were in the failure *** patients in the failure group had an intermittent exotropia(IXT)ofsurvival rate steadily decreases with the exodrift,but the amount of the exodrift decreases with long-term *** final outcomes demonstrate favorable results via surgic

关键词： long-term outcome survival analysis intermittent exotropia surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-task regression learning for survival analysis via prior information guided transductive matrix completion

引用

Frontiers of Computer Science 2020年第5期14卷 99-112页

作者： Lei Chen Kai Shao Xianzhong Long Lingsheng Wang Jiangsu Key Laboratory of Big Data Security and Intelligent Processing Nanjing University of Posts and TelecommunicationsNanjing210023China MIIT Key Laboratory of Pattern analysis and Machine Intelligence Nanjing University of Aeronautics and AstronauticsNanjing211106China

survival analysis aims to predict the occurrence time of a particular event of interest,which is crucial for the prognosis analysis of ***,due to the limited study period and potential losing tracks,the observed data inevitably involve some censored instances,and thus brings a unique challenge that distinguishes from the general regression *** addition,survival analysis also suffers from other inherent challenges such as the high-dimension and small-sample-size *** address these challenges,we propose a novel multi-task regression learning model,i.e.,prior information guided transductive matrix completion(PigTMC)model,to predict the survival status of the new ***,we use the multi-label transductive matrix completion framework to leverage the censored instances together with the uncensored instances as the training samples,and simultaneously employ the multi-task transductive feature selection scheme to alleviate the overfitting issue caused by high-dimension and small-sample-size *** addition,we employ the prior temporal stability of the survival statuses at adjacent time intervals to guide survival ***,we design an optimization algorithm with guaranteed convergence to solve the proposed PigTMC ***,the extensive experiments performed on the real microarray gene expression datasets demonstrate that our proposed model outperforms the previously widely used competing methods.

关键词： survival analysis matrix completion multi-task regression transductive learning multi-task feature selection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinicopathological features and survival analysis of gastroenteropancreatic neuroendocrine neoplasms: a retrospective study in a single center of China

引用

Chinese Journal of Cancer Research 2015年第3期27卷 258-266页

作者： Xuelong Jiao Yujun Li Hongyan Wang Shanglong Liu Dongfeng Zhang Yanbing Zhou General Surgery Department The Affiliated Hospital of Qingdao University Pathology Department The Affiliated Hospital of Qingdao University Department of Epidemiology and Health Statistics The Medical College of Qingdao University

Objective： To investigate the clinicopathological features, survival and prognostic factors for gastroenteropancreatic neuroendocrine neoplasms（GEP-NENs） in a Chinese ***： We investigated 154 consecutive patients（88 males, 66 females; median age 56 years, age range 9-86 years） diagnosed with GEP-NENs between 2001 and 2013 at The Affiliated Hospital of Qingdao University. Demographic, clinical and pathological variables and survival data were ***： The pancreas was the most common site of involvement（63/154, 40.9%）. Tumor size varied from 0.3 to 16.0 cm（median, 1.2 cm）. The patients were followed up for a median period of 22 months（range, 1-157 months）. The estimated 3- and 5-year overall survival（OS） rates for all patients were 84.0% and 81.9%, respectively. Multivariate analysis showed that larger tumor size, lymphatic metastases and distant metastases were significant predictors for poor survival ***： Our data provide further information on the clinicopathological features of GEP-NENs in China. Additionally, we identified tumor size, lymphatic metastases and distant metastases as independent prognostic factors for long-term survival.

关键词： Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) clinicopathological characteristics survival analysis Ki-67 retrospective study

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation by survival analysis on Effect of Traditional Chinese Medicine in Treating Children with Respiratory Syncytial Viral Pneumonia of Phlegm-Heat Blocking Fei Syndrome

引用

Chinese Journal of Integrative Medicine 2009年第2期15卷 95-100页

作者：杨燕汪受传白文静李瑞丽艾军 Nanjing University of Traditional Chinese Medicine China Academy of Chinese Medical Sciences

Objective:To objectively evaluate the clinical effect of traditional Chinese medicine in treating children s respiratory syncytial viral pneumonia(RSVP) of phlegm-heat blocking Fei(肺) syndrome(PHBFS). Methods:A single-blinded multi-center,blocked,randomized and parallel-controlled method was *** clinical study was carried out on 206 children with RSVP-PHBFS who were assigned to two groups,108 in the test group treated through intravenous dripping of Qingkailing Injection(清开灵注射液) in combination of or...

关键词： children respiratory syncytial viral pneumonia phlegm-heat blocking Fei syndrome therapeutic effect evaluation survival analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An evaluation of treatments and survival rates for pancreatic adenocarcinoma through survival analysis with inverse probability of treatment weighting:a population-based study

引用

Journal of Pancreatology 2021年第1期4卷 18-27页

作者： Suzhen Wang Chen Wang Fuyan Shi Enxue Tao Gaopei Zhu Juan Li Jianing Feng Xiaoxuan Wang Jing Guo Qingfeng Zheng Bo Zhang Department of Health Statistics School of Public HealthWeifang Medical UniversityWeifangShandong ProvinceChina Department of Computer Science Rutgers UniversityPiscatawayNJUSA Intramural Outpatient Clinic Weifang Medical UniversityWeifangShandong ProvinceChina Department of Health Policy and Management School of Public HealthPeking UniversityBeijingChina Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Neurology and ICCTR Biostatistics and Research Design Center Boston Children’s Hospital and Harvard Medical SchoolBostonMAUSA

Objective:This study conducted inverse probability of treatment weighting(IPTW)survival analysis to examine survival in pancreatic adenocarcinoma ***:In this population-based study,data from the Surveillance,Epidemiology,and End Results program of the United States were analyzed to identify patients diagnosed with adenocarcinoma of the pancreas 2004 to *** in survival rates were examined among patients who underwent pancreatectomy alone,radiotherapy alone,and those who had pancreatectomy plus adjuvant ***-Meier estimates and Cox proportional hazards models with the IPTW were performed to determine the effect of different treatments on overall and cancer-specific *** study was approved by the Ethics Review Board of Weifang Medical ***:A total of 8191 patients were included,with 3409 taking pancreatectomy only,2865 taking radiotherapy only,and 1917 taking pancreatectomy plus adjuvant *** who received surgery plus adjuvant radiotherapy had statistically a higher survival rate than those who received the other 2 *** analysis with the IPTW for the 3 different groups showed that the difference in median overall survival time among these patient groups was ***:Using IPTW survival analysis,the present study shows that surgery with adjuvant radiotherapy is significantly associated with improved overall and cancer-specific survival among patients with pancreatic adenocarcinoma.

关键词： Cox proportional hazard models Generalized boosted models Inverse probability of treatment weighting Pancreatic adenocarcinoma Propensity score survival analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

survival analysis of Logistics Service Providers: An Empirical Study of Chengdu, Area in China

引用

Open Journal of Statistics 2020年第6期10卷 915-935页

作者： Guoqi Li Yihuan Tu Lihao Duan Jin Zhang Lei Huang Wanshan Wu Zhuoshi Lv School of Transportation and Logistics Southwest Jiaotong University Chengdu Sichuan China National Engineering Laboratory of Integrated Transportation Big Data Application Technology Chengdu China National United Engineering Laboratory of Integrated and Intelligent Transportation Chengdu China School of Mathematics Southwest Jiaotong University Chengdu China

This paper worked on a sample of 6791 logistics establishments registered in Chengdu, China over the period 1984-2016 to understand the survival status of logistics service providers (LSPs) by non-parametric Kaplan-Meier estimation, together with Cox proportional hazard regression model, to identify factors affecting the failure of LSPs. In particular, it studies the interaction effect between LSPs’ size and entry timing and location. The empirical results show that: 1) Regarding the survival time, 1365 of the 6791 sample LSPs exited from the market by 2017. The exit rate is 20.1%, and the average life of the 6791 LSPs is about 6 years. 2) The survival of LSPs depends on their typology, ownership structure. And there is no significant difference in the probability of survival for both independent LSPs and logistics branches after controlling the effects of other variables. 3) Location and entry timing also play an important role in the survival of small-scale LSPs, but these factors cannot explain large-scale LSPs’ failure.

关键词： Logistics Service Providers survival analysis Kaplan-Meier Estimation Cox Proportional Hazard Regression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A New Statistical Modeling Approach for survival analysis of Cancer Patients—Multiple Myeloma Cancer

引用

Open Journal of Applied Sciences 2021年第4期10卷 365-378页

作者： Lohuwa Mamudu Chris P. Tsokos Department of Mathematics and Statistics University of South Florida Tampa USA

Background: The Cox Proportional Hazard (Cox-PH) model has been a popularly used method for survival analysis of cancer data given the survival times as a function of covariates or risk factors. However, it is very seldom to see the assumptions for the application of the Cox-PH model satisfied in most of the research studies, raising questions about the effectiveness, robustness, and accuracy of the model predicting the proportion of survival times. This is because the necessary assumptions in most cases are difficult to satisfy, as well as the assessment of interaction among covariates. Methods: To further improve the therapeutic/treatment strategy for cancer diseases, we proposed a new approach to survival analysis using multiple myeloma (MM) cancer data. We first developed a data-driven nonlinear statistical model that predicts the survival times with 93% accuracy. We then performed a parametric analysis on the predicted survival times to obtain the survival function which is used in estimating the proportion of survival times. Results: The new proposed approach for survival analysis has proved to be more robust and gives better estimates of the proportion of survival than the Cox-PH model. Also, satisfying the proposed model assumptions and finding interactions among risk factors is less difficult compared to the Cox-PH model. The proposed model can predict the real values of the survival times and the identified risk factors are ranked according to the percent of contribution to the survival time. Conclusion: The new proposed nonlinear statistical model approach for survival analysis of cancer diseases is very efficient and provides an improved and innovative strategy for cancer therapeutic/treatment.

关键词： Health Science Multiple Myeloma Cancer Cancer Therapeutic Cox-PH Model Statistical Model survival analysis Probability Estimation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：