Clinicopathological features and survival analysis of gastroenteropancreatic neuroendocrine neoplasms: a retrospective study in a single center of China

作     者：Xuelong Jiao Yujun Li Hongyan Wang Shanglong Liu Dongfeng Zhang Yanbing Zhou 

作者机构：General Surgery DepartmentThe Affiliated Hospital of Qingdao University Pathology DepartmentThe Affiliated Hospital of Qingdao University Department of Epidemiology and Health StatisticsThe Medical College of Qingdao University 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2015年第27卷第3期

页      面：258-266页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Disclosure: The authors declare no conflict of interest 

主　　题：Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) clinicopathological characteristics survival analysis Ki-67 retrospective study 

摘      要：Objective： To investigate the clinicopathological features, survival and prognostic factors for gastroenteropancreatic neuroendocrine neoplasms（GEP-NENs） in a Chinese ***： We investigated 154 consecutive patients（88 males, 66 females; median age 56 years, age range 9-86 years） diagnosed with GEP-NENs between 2001 and 2013 at The Affiliated Hospital of Qingdao University. Demographic, clinical and pathological variables and survival data were ***： The pancreas was the most common site of involvement（63/154, 40.9%）. Tumor size varied from 0.3 to 16.0 cm（median, 1.2 cm）. The patients were followed up for a median period of 22 months（range, 1-157 months）. The estimated 3- and 5-year overall survival（OS） rates for all patients were 84.0% and 81.9%, respectively. Multivariate analysis showed that larger tumor size, lymphatic metastases and distant metastases were significant predictors for poor survival ***： Our data provide further information on the clinicopathological features of GEP-NENs in China. Additionally, we identified tumor size, lymphatic metastases and distant metastases as independent prognostic factors for long-term survival.