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A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.J.Dijkstra C.Mota J.Bauer H.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa M.B.Baker L.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending surface functionalization surface density Click chemistry Human

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Electrochemical single nucleotide polymorphisms genotyping on surface immobilized three-dimensional branched DNA nanostructure

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Science China Chemistry 2011年第8期54卷 1273-1276页

作者： GE ZhiLei PEI Hao WANG LiHua SONG ShiPing FAN ChunHai Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China

An electrochemical assay for single nucleotide polymorphisms (SNPs) genotyping is reported. Although electrochemical method is sensitive for DNA detection on surfaces, the ability of surface assay to precisely recognize DNA hybridization event is sacrificed to some extent due to the crowded confined surfaces environments that disfavor DNA hybridization. In the present study, we employed branched tetrahedron structure probes (TSPs) to replace regular linear single stranded DNA capture probes that were immobilized on solid surfaces. This three-dimensional DNA nanostructure lowers the density of immobilized DNA probes on confined surfaces, providing a hybridization environment that is similar to homogenous solution. This TSP-based electrochemical assay reveals excellent performance for SNPs genotyping with concentration as low as 1 nM.

关键词： DNA nanostructure surface density electrochemical

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Theoretical Optimization of the Production of Heating Layers Using Local Wool Fibers

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Engineering（科研） 2022年第12期14卷 578-590页

作者： Matluba Abdurashid Kizi Nazarova Juramirza Abdiramatovich Kayumov Axtam Akramovich Qosimov Abdulrasul Abdumajitovich Mahmudov Department of “Construction and Technology of Light Industrial Products” Namangan Institute of Engineering and Technology Namangan Uzbekistan Department of Textile Engineering Zhejiang Sci-Tech University Hangzhou China Department of Technology of Goods of Textile Industry Namangan Institute of Engineering and Technology Namangan Uz-bekistan Department of “Metrology Standardization and Quality Management” Namangan Institute of Engineering and Technology Namangan Uzbekistan Department of General Technics Fergana Polytechnics Institute Fergana Uzbekistan

Science is the basis of the country’s development and wealth. In particular, it is necessary to effectively use advanced scientific developments and technical achievements in order to strengthen the economy in the period when the desire for innovation in all fields is still growing. In theoretical-experimental Scientific Research work, both theoretical and experimental results are achieved, and it is more useful to withstand more theoretical-experimental loads for a longer period of time. The occurrences in the production process of natural wool fiber technologists are a complex of physical and mechanical phenomena, which can be used only by the modern achievements of science and technology. In most cases, the parameter relationship with the factors influencing the technological process or the object can open a curve without any other things.

关键词： Wool Polyester Fiber Content Heating Layer surface density Result Unwanted Factors Chemical Fiber Experiments Heat Storage Determine

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Manufacture of Single Cotton Fabric with New Composition, Specified Bend from Yarn Gathered from Local Raw Material Cotton Fiber

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Journal of Textile Science and Technology 2023年第4期9卷 244-252页

作者： Dilshodbek Olimjonov Khasanboy Ugli Mirxojayev Mirjamol Mirkarimovich Department of Knitting Technology Namangan Institute of Textile Industry Namangan Uzbekistan

The article created 21 types of fabrics for the new composition of dublerin. Tests of various types of weave, fiber composition and yarn count are shown in various ways. The physical and mechanical parameters of the test samples were determined and analyzed at the “Accredited Testing Laboratory for Light Industry Products” at the State Unitary Enterprise “Namangan Center for Testing and Certification”. The reason for such a low performance of the motos of number 15 produced in the scientific research work is that the linear densities of the body and the yarn are four times different, despite the weaving of the fabric. Elongation at break is also dependent on penetration.

关键词： Weaves Warp Weft Dublerin Canvas Reps surface density Fabric

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Study of the Effect of Changes on the Technological and Physical-Mechanical Properties of Knitting in a New Structure

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Engineering（科研） 2021年第6期13卷 287-299页

作者： Shahboz Shokirjonugli Shogofurov Iroda Ibrohimovna Kamalova Kurbonali Madaminovich Xolikov Faculty of Technology of Light Industry Namangan Institute of Engineering and Technology Namangan Uzbekistan

In this article, we compared four types of knitted fabrics with high two-ply shape retention. Experimental samples of a two-layer knitted fabric have been developed and graphic symbols have been applied on a flat-need... 详细信息

关键词： Knitwear Double Knit Hoop Yarn Flat Dimensional Lightness Hoop Height surface density Pattern density Hoop Strip Length Polyacrylonitrile

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