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Mechanism of Cerium Ions Scavenging superoxide radical

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Journal of Rare Earths 1998年第1期16卷 47-51页

作者：王金胜郭春绒程玉香 Department of Basic Science Shanxi Agricultural University Taigu 030801 China Jinzhong Health School Taigu 030801 China

The mechanism of cerium ions scavenging superoxide radical(O÷2) has been studied. The results show that (1) Ce^3+ can reduce O÷2 to H_2O_2 while it is oxidized to Ce^4+; (2) Ce^4+ can oxidize O÷2 ... 详细信息

关键词： Rare earths Cerium ion superoxide radical Flavin

NIR-absorbing superoxide radical and hyperthermia photogenerator via twisted donor-acceptor-donor molecular rotation for hypoxic tumor eradication

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Science China Materials 2021年第12期64卷 3101-3113页

作者： Yucheng Zhu Qinghua Wu Chao Chen Guoliang Yang Hongliang Cao Yun Gao Lijuan Jiao Erhong Hao Weian Zhang Shanghai Key Laboratory of Functional Materials Chemistry School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Laboratory of Functional Molecular Solids Ministry of EducationAnhui Laboratory of Molecule Based Materials(State Key Laboratory Cultivation Base)and School of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241000China

Hypoxia severely impedes the therapeutic efficacies of tumor chemotherapy, radiotherapy and conventional photodynamic therapy(type Ⅱ PDT). Herein, we proposed a nonplanar near-infrared(NIR)-absorbing hyperthermia and superoxide radical(O^(-)_(2)) photogenerator(TB) against hypoxic tumors. TB particularly possessed a favorable O^(-)_(2) generation capability under 808 nm laser irradiation with the donoracceptor-donor(D-A-D) molecular structure. Moreover, owing to molecular rotation, potent hyperthermia was realized under continuous laser irradiation. For the usage of hypoxic tumor treatment, TB was encapsulated by a block copolymer,poly(ethylene glycol)-b-poly(latic acid)(PEG_(45)-b-PLA_(24)), to fabricate phototheranostic nanoparticles(TB NPs). Due to the twisted molecular structure and the shielding effect of long alkyl chains, the π-π stacking-induced quenching of O^(-)_(2) could be reduced after the fabrication of nano-assemblies. Significantly, TB NPs exhibited satisfactory O^(-)_(2) generation for type I PDT and a simultaneously distinct photothermal conversion efficiency(PCE, 62%) for photothermal therapy(PTT)to combat hypoxic tumor cells. Moreover, the high PCE endowed TB NPs with high-performance photoacoustic(PA)and photothermal imaging capability. In vivo experiments demonstrated that TB NPs possessed an outstanding phototherapeutic efficacy for eradicating hypoxic tumors. This study established a novel approach for constructing oxygenindependent phototherapeutic reagent against hypoxic tumors.

关键词： tumor hypoxia superoxide radical hyperthermia D-A-D structure molecular rotation

Ratiometric/Turn-on Fluorescent Probes with High Sensitivity and Specificity for Quantitative Detection of superoxide radical in Biological Systems

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Ratiometric/Turn-on Fluorescent Probes with High Sensitivity...

Effects of superoxide radical on Root System Growth and Auxin Distribution in Rice

第十一届全国化学生物学学术会议

作者： Kai-yun Ji Jin-peng Shan Yang-ping Liu Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical University

superoxide radical(O) plays vital roles in normal physiological processes and many diseases. Fluorescent technique has been established as the most widely used method for detection and imaging of Odue to high sensitivity and high temporal and spatial resolution. However, due to abundant antioxidants in biological systems and low reactivity of fluorescent probes with O, quantitative detection and imaging of Oat physiological levels is still challenging. To address this issue, herein, we report the synthesis of 19 Ofluorescent probes through conjugation of fluorophores, coumarin(CM), naphthalimide(NA) and 9 H-1,3-dichloro-7-hydroxy-9,9-dimethylacridine-2-one(DDAO) with trifluoromethanesulfonyl group via self-immolative linkers. Our results showed that 1) the introduction of the self-immolative linker increases the stability and specificity of the probes;2) increasing the electron-withdrawing property of the linker significantly enhances the reactivity of the corresponding probes with O;3) CM-and NA-based probes exhibit distinct emissions before and after reaction with O, enabling ratiometric detection of O. Our present study provides a new strategy for design of Oprobes and these probes also show great potential in quantitative detection and imaging of Oin various biological systems.

关键词： superoxide radical Fluorescent probe Self-immolative linker High Sensitivity

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Agricultural Science & Technology 2012年第8期13卷 1655-1657,1663页

作者：任静冯婷婷陈振华刘乐雨冯永永高华健赵凤云山东理工大学生命科学学院山东淄博255049

[Objective] This study aimed to investigate the effect of superoxide radical on root system growth and auxin distribution in rice （Oryza sativa L. cv Zhonghua No.11）. [Method] With rice Zhonghua *** as the experimental material, the effects of DDC （SOD inhibitor） and Tiron （superoxide radical scavenger） on the root system growth, superoxide radical generation and root system auxin distribution in rice were analyzed. [Result] The growth and elongation of primary and adventitious roots were significantly promoted by DDC, while Tiron significantly inhibited the growth and elongation of shoots, primary roots and their lateral roots, and also suppressed the formation and growth of the adventitious roots as well as the elongation of their lateral roots. The superoxide radical was increased with the induction of DDC, while Tiron decreased the accumulation of superoxide radical. Increased accumulation of auxin in the vascular bundle and behind the elongation zone was observed in DDC- treated roots, while the treatment with Tiron resulted in a decrease of auxin in the same position. [Conclusion] This study indicated that the regulation of rice root sys- tem growth by superoxide radical was closely related with the accumulation and distribution of auxin.

关键词： superoxide radical Rice Root System Auxin

Anthraquinone acted as a catalyst for the removal of triphenylmethane dye containing tertiary amino group: Characteristics and mechanism

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Journal of Environmental Sciences 2022年第11期34卷 148-158页

作者： Ying Gao Weihuang Zhu Junli Li Wenqi Liu Xue Li Jianfeng Zhang Tinglin Huang Key Laboratory of Northwest Water Resources Environment and EcologyMinistry of EducationXi’an University of Architecture and TechnologyXi’an 710055China Shaanxi Key Laboratory of Environmental Engineering Xi’an University of Architecture and TechnologyXi’an 710055China

Herein,we found that anthraquinone(AQ)acted as a catalyst for the rapid and effective removal of triphenylmethane dye containing tertiary amino group(TDAG).Results showed that AQ had an enhanced catalytic reactivity towards the removal of TDAG compared to hydro-quinone,which was further proved and explained using density functional theory(DFT)*** could achieve a TDAG removal efficiency and rate of approximately 100%and 0.3583 min^(−1),respectively,within 20 *** experiments and electron paramagnetic resonance(EPR)tests indicated that the superoxide radical(O_(2)^(•−))generated through the catalytic reduction of an oxygen molecule(O_(2))by AQ contributed to the effective removal of the *** addition,itwas found that the electrophilic attack of the O_(2)^(•−)radical on the TDAG was the driving force for the dye degradation *** the pH led to protonation of the substituted group of AG,which resulted in formation of an electron deficient center in the TDAGmolecule(TDAG-EDC+)through delocalization of the π ***,the possibility of the electrophilic attack for the dye by the negative O_(2)^(•-)radical was significantly *** study revealed that the H+and the O_(2)^(•−)generated by the catalytic reduction of O_(2) have synergistic effects that led to a significant increase in the dye removal rate and efficiency,which were higher than those obtained through persulfate oxidation.

关键词： Anthraquinone Oxygen reduction superoxide radical Catalytic degradation Triphenylmethane dye

Influence of PEG 6000 on gallium oxide(Ga_2O_3) polymorphs and photocatalytic properties

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Science China Chemistry 2015年第3期58卷 532-538页

作者： Xiaohui Chai Zhihong Liu Yingping Huang Key Laboratory of Analytical Chemistry for Biology and Medicine Ministry of Education College of Chemistry and Molecular Sciences Wuhan University Engineering Research Center of Eco-Environment in Three Gorges Reservoir Region Ministry of Education China Three Gorges University Collaborative Innovation Center for Geo-Hazards and Eco-Environment in Three Gorges Area Hubei Province China Three Gorges University

Three different nanorod-like gallium oxides with mono/poly-crystalline nature(α, β, and α/β-Ga2O3) were prepared by regulating the amount of polyethylene glycol(PEG) 6000 in the range of 0.2–0.8 g proportionally via a hydrothermal method combined with further calcination. The bandgap of the products, given by UV-Vis diffuse reflectance spectra(UV-Vis DRS), was in the order of α-Ga2O3 > α/β-Ga2O3 > β-Ga2O3. To further investigate the photocatalysis performance of the catalysts, the decomposition of rhodamine B(Rh B) by Ga2O3 under UV light illumination(λ radical(·OH) and superoxide radical(O·-2), which were confirmed by electron paramagnetic resonance(EPR).

关键词： gallium oxides photocatalysis UV light hydroxyl radical superoxide radical

Fabrication and Excellent Antibacterial Activity of Well-defined CuO/Graphdiyne Nanostructure

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Chemical Research in Chinese Universities 2021年第6期37卷 1341-1347页

作者： PAN Chuanqi LIU Xiaoxuan ZHANG Xiang MAO Feihong XU Peiyan ZHU Yuhua DENG Hongtao LUO Zhu SUN Hongwei ZHANG Lizhi GUO Yanbing Key Laboratory of Pesticide&Chemical Biology Ministry of EducationInstitute of Environmental and Applied ChemistryCollege of ChemistryCentral China Normal UniversityWuhan430079P.R.China

Copper oxide(CuO),due to its low cost,good chemical and physical stability,has recently been given special attention as a potential candidate for antibacterial ***,developing novel CuO nanocomposites with improved antibacterial property and unraveling the interface promotion mechanism has been a fundamental challenge for ***,well-defined CuO/graphdiyne(CuO/GDY)nanostructures with uniformly anchored CuO nanoparticles(ca.4.5 nm)have been *** CuO/GDY nanostructure exhibited superior *** inactivation efficiency,which is nearly 19 times and 7.9 times higher than the bare GDY and commercial CuO,*** improved *** inactivation performance was mainly due to the increased reactive·O_(2)−species generated by the activation of molecular O2 over CuO/GDY *** findings demonstrate the efficient antibacterial activity of well-defined CuO/GDY nanostructures and provide insights on the development of efficient GDY-based antibacterial materials.

关键词： Graphdiyne CuO/GDY nanocomposite Escherichia coli Antibacterial superoxide radical

The degradation pathways of contaminants by reactive oxygen species generated in the Fenton/Fenton-like systems

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Chinese Chemical Letters 2024年第10期35卷 158-169页

作者： Chi Zhang Ning Ding Yuwei Pan Lichun Fu Ying Zhang Tianjin Key Laboratory of Environmental Technology for Complex Trans-Media Pollution College of Environmental Science and EngineeringNankai UniversityTianjin300350China Key Laboratory of Cleaner Production and Integrated Resource Utilization of China National Light Industry Beijing Technology and Business University.Beijing100048China College of Biology and the Environment Nanjing Forestry UniversityNanjing 210037China School of Iron and Steel Soochow UniversitySuzhou 205000China Key Laboratory of Pollution Process and Environmental Criteria Ministry of EducationCollege of Environmental Science and EngineeringNankai UniversityTianjin300350China

Reactive oxygen species(ROSs)in Fenton process are of great importance in treating contaminants in *** is crucial to understand their chemical properties,formation,and reaction mechanisms with *** review summarizes the reactive oxygen species in Fenton process,including hydroxyl radical(·OH),superoxide radical(O_(2)·-),singlet oxygen(1O_(2)),hydroperoxyl radical(HO_(2)·),and high-valent iron.·OH shows a trend to react with chemistry groups with abundant electrons through H-atom abstraction,radical adduct formation and single electron *** transfer is discovered to be an important pathway when1O_(2)degrades organic ***-opening andβ-scission are proposed to be the possible ways of1O_(2)to certain *** abstraction,nucleophilic substitution,and single electron transfer are proposed to explain how O_(2)·-degrade *** the conjugated acid of O_(2)·-,radical adduct formation and H-atom abstraction are reported for the reaction mechanisms of hydroperoxyl ***-valent iron in Fenton,namely Fe(IV),reacts with certain pollutants via single-or two-electron *** review is important for researchers to understand the ROSs produced in Fenton and how they react with pollutants.

关键词： Fenton Hydroxyl radical superoxide radical Singlet oxygen Hydroperoxyl radical High-valent iron

具有扭曲D-A-D转子结构的近红外光疗试剂能够同时产生超氧自由基和光热用于消除乏氧肿瘤（英文）

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Science China Materials 2021年

作者：朱玉呈吴清华陈超杨国梁曹红亮杲云焦莉娟郝二宏张伟安 ShanghaiKeyLaboratoryofFunctionalMaterialsChemistry SchoolofMaterialsScienceandEngineeringEastChinaUniversityofScienceandTechnology LaboratoryofFunctionalMolecularSolids MinistryofEducationAnhuiLaboratoryofMoleculeBasedMaterials(StateKeyLaboratoryCultivationBase)andSchoolofChemistryandMaterialsScienceAnhuiNormalUniversity

肿瘤乏氧微环境严重抑制了肿瘤化疗、放疗及II型光动力治疗的疗效.因此,开发非氧气依赖性的肿瘤治疗方式具有重要意义.在此,我们设计了一种超稳定的近红外吸收的光热和超氧自由基(O2-·)供体（TB）.由于D-A-D分子结构,在808 nm激光照射... 详细信息

肿瘤乏氧微环境严重抑制了肿瘤化疗、放疗及II型光动力治疗的疗效.因此,开发非氧气依赖性的肿瘤治疗方式具有重要意义.在此,我们设计了一种超稳定的近红外吸收的光热和超氧自由基(O2-·)供体（TB）.由于D-A-D分子结构,在808 nm激光照射下, TB能够产生大量O2-·.此外,由于电子供体同时还充当了转子基元,TB还能够在连续激光照射下产生极强的光热.为了将TB应用于乏氧肿瘤治疗, TB被嵌段共聚物PEG45-b-PLA24封装以制成纳米颗粒（TB NPs）.扭曲的分子结构和长烷基链的屏蔽效应有效降低了组装体由于聚集所导致的O2-·淬灭.组装而成的TB NPs仍具有令人满意的O2-·生成能力和较高的光热转化效率,因而TB NPs可被用于乏氧肿瘤治疗.此外,由于TB NPs的光热转换效率较高,其可被用于光声成像和光热成像.在活体抗肿瘤实验中,通过连续光照,TB NPs可以完全消除乏氧肿瘤.本研究为设计非氧依赖性的光疗试剂用于乏氧肿瘤治疗提供了一种全新的策略.

关键词： tumor hypoxia superoxide radical hyperthermia DA-D structure molecular rotation