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Chinese Journal of Traumatology 2022年第2期25卷 115-117页

作者： Geng-Huan Wang He-Ping Shen Zheng-Min Chu Jian-Guo Shen Jian Shen Department of Neurosurgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing314000Zhejiang ProvinceChina

It is extremely dangerous to treat the posterior third of the superior sagittal sinus (PTSSS) surgically, since it is usually not completely ligated. In this report, the authors described the case of a 27-year-old man with a ruptured and defective PTSSS caused by an open depressed skull fracture, which was treated by ligation of the PTSSS and the patient achieved a positive recovery. The patient's occiput was hit by a height-limiting rod and was in a mild coma. A CT scan showed an open depressed skull fracture overlying the PTSSS and a diffuse brain swelling. He underwent emergency surgery. When the skull fragments were removed, a 4 cm segment of the superior sagittal sinus (SSS) and the adjacent dura mater were removed together with bone fragments. Haemorrhage occurred and blood pressure dropped. We completed the operation by ligating the severed ends of the fractured sagittal sinus. One month after the operation, apart from visual field defects, he recovered well. In our opinion, in primary hospitals, when patients with severely injured PTSSS cannot sustain a long-time and complicated operation, e.g., the bypass using venous graft, and face life-threatening conditions, ligation of the PTSSS is another option, which may unexpectedly achieve good results.

关键词： Depressed skull fracture superior sagittal sinus Ligation Prognoses

Microarray analysis of gene expression after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats

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Chinese Medical Journal 2014年第4期127卷 734-741页

作者： Jiang Lei Dong Zhao Li Fengpeng Liu Ruozhuo Qiu Enchao Wang Xiaolin Yu Shengyuan Department of Neurology Chinese People&#39 s Liberation Army General Hospital Beijing 100853 China

Background The molecular and cellular origins of migraine headache are among the most complex problems in contemporary neurology.Up to now the pathogenesis of migraine still remains unclearly defined.The objective of this study was to explore new factors that may be related to the mechanism of migraine.Methods The present study performed a comprehensive analysis of gene expression in the trigeminal nucleus caudalis induced by electrical stimulation of dura mater surrounding the superior sagittal sinus in conscious rats using microarray analysis followed by quantitative real-time reverse-transcribed polymerase chain reaction （qRT-PCR） verification.Student＆#39;s two sample t-test was employed when two groups were compared.A P value 〈0.05 was considered to be statistically significant.Results Comparing the placebo and the electrical stimulation groups,40 genes were determined to be significantly differentially expressed.These significantly differentially expressed genes were involved in many pathways,including transporter activity,tryptophan metabolism,G protein signaling,kinase activity,actin binding,signal transducer activity,anion transport,protein folding,enzyme inhibitor activity,coenzyme metabolism,binding,ion transport,cell adhesion,metal ion transport,oxidoreductase activity,mitochondrion function,and others.Most of the genes were involved in more than 2 pathways.Of particular interest is the up-regulation of Phactr3 and Akap5 and the down-regulation of Kdr.Conclusion These findings may provide important clues for a better understanding of the molecular mechanism of migraine.

关键词： migraine electric stimulation superior sagittal sinus microarray analysis

Vascular changes caused by deep brain stimulation using double-dose gadolinium-enhanced brain MRI

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Neural Regeneration Research 2014年第3期9卷 276-279页

作者： Byeong Sam Choi Yong Hwan Kim Sang Ryong Jeon Department of Neurological Surgery Haeundae Paik Hospital Inje University College of Medicine Department of Computer Science and Engineering University of Notre Dame Department of Neurological Surgery Asan Medical Center University of Ulsan College of Medicine

We retrospectively analyzed the clinical data of 32 patients with medically intractable idiopathic Parkinson＇s disease who had undergone staged bilateral deep brain stimulation of the subtha-lamic nuclei from January 2007 to May 2011. The vascularture of the patients who received two deep brain stimulations was detected using double-dose gadolinium-enhanced brain MRI. The dimensions of straight sinus, superior sagittal sinus, ipsilateral internal cerebral vein in the tha- lamic branch and ipsilateral anterior caudate vein were reduced. These findings demonstrate that bilateral deep brain stimulation of the subthalamic nuclei affects cerebral venous blood flow.

关键词： nerve regeneration gadolinium-enhanced brain MRI deep brain stimulation subtha-lamic nuclei vascularture straight sinus superior sagittal sinus internal cerebral vein in the tha-lamic branch anterior caudate vein KRCF National Agenda Project neural regeneration

Neurogenic nitric oxide facilitates the central nociceptive transmission of migraine attacks

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Neural Regeneration Research 2011年第3期6卷 213-218页

作者： Wang, Hebo Qi, Huijun Yu, Shengyuan Yang, Sumian Liu, Ruozhuo Hebei Gen Hosp Dept Neurol Shijiazhuang 050051 Hebei Peoples R China Hebei Gen Hosp Dept Emergency Shijiazhuang 050051 Hebei Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Neurol Beijing 100853 Peoples R China

Recent studies have shown that nitric oxide （NO） can induce migraine attacks at three possible sites of action： nitroxidergic nerves, the vascular endothelium, and the central nervous system. Most previous studies have focused on the former two sites of action. Several experiments using exogenic NO donors have suggested that nitroglycerin may induce migraine via central mechanisms. However, few studies have investigated the source of the NO involved in the central mechanisms of migraine. The present study used a cat model of migraine to represent migraine attacks in humans. We performed immunochemical staining of successive frozen sections of the brainstem and upper cervical spinal cord, and then used c-Fos protein expression to label nerve cell activation. We observed the effects of N^ω-nitro-L-arginine methyl ester （L-NAME）, a non-selective nitric oxide synthase （NOS） inhibitor, and 7-nitroindozole （7-NI）, a selective neuronal NOS inhibitor, on c-Fos and nNOS expression, which were induced by electrical stimulation to the dura mater near the superior sagittal sinus. The results demonstrated that c-Fos or nNOS immunoreactive cells was concentrated in the superficial layers （laminae Ⅰ and Ⅱ） of the spinal nucleus of trigeminal nerve. L-NAME and 7-NI pre-treatment significantly decreased c-Fos and neurogenic NOS expression; and there was a significant linear correlation between c-Fos and NOS expression （r = 0.858 2, P 〈 0.01）. These findings suggest that neurogenic NO could facilitate migraine nociceptive transmission to second-order neurons of the trigeminal nerve. However, L-NAME and 7-NI may block the activation of neurons in the spinal nucleus of the trigeminal nerve by inhibiting NO synthesis, and thereby attenuate acute migraine attacks.

关键词： migraine c-Fos nitric oxide dura mater neurogenic superior sagittal sinus