检索结果-南通市图书馆

Acute and subchronic toxicity as well as evaluation of safety pharmacology of modified pulsatilla granules

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2017年第3期16卷 671-678页

作者： JIA Rui-lin SONG Xu GUO Yu-fei YIN Zhong-qiong LIU Fei XIONG Juan LIU Qiu-yan JIA Ren-yong LI Li-xia ZOU Yuan-feng YIN Li-zi HE Chang-liang LIANG Xiao-xia YUE Gui-zhou College of Veterinary Medicine Sichuan Agricultural University Chengdu 611130 P.R. China Jinling Institute of Technology Nanjing 211169 P.R. China College of Science Sichuan Agricultural University Ya'an 625014 P.R.China

The present study investigated acute and subchronic toxicity and safety pharmacology of modified pulsatilla granules（MPG）to provide a basis for a comprehensive understanding of MPG *** results of acute toxicity testing showed that the median lethal dose of MPG was more than 5 000 mg kg^-1,suggesting that MPG was considered as practically *** subchronic toxicity study for 30 days was conducted by daily oral administration at doses of 375,750 and 1 500 mg kg^-1 in Sprague-Dawley *** results of subchronic toxicity study showed that the body weight and relative organ weight were not significantly changed by administration of *** clinical chemistry study showed that MPG could induce kidney and liver *** histopathological,mild lesions in liver and kidney were also observed,suggesting that the liver and kidney might be potential target organs of *** the safety pharmacology study,MPG did not exhibited any side effects to rats in cardiovascular system,respiratory system and central nervous *** results suggested that MPG could be considered safe for veterinary use.

关键词： modified pulsatilla granules acute toxicity subchronic toxicity safety pharmacology

A subchronic toxicity test of ethyl acetate extract from endophytic fungus Penicillium sp. of kunyit putih(Curcuma zedoaria) against Swiss albino mice

在线全文

学校读者我要写书评

暂无评论

Journal of Chinese Pharmaceutical Sciences 2018年第2期27卷 123-130页

作者： Muharni Heni Yohandini Department of Chemistry Faculty of Mathematics and Natural Sciences University of Sriwijaya

Ethyl acetate extract of endophytic fungus from Penicillium sp. of kunyit putih showed antibacterial activity in vivo but no acute toxicity. However, the extract may have toxic effects on major organs for long-term consumption. This study was carried out in order to test sub-chronic toxicity of the ethyl acetate from endophytic fungus Penicillium sp. of kunyit putih against mice(Mus musculus). A total of 50 male mice were divided into five groups. Groups Ⅰ, Ⅱ, Ⅲ and Ⅳ were orally administered with ethyl acetate extracts of 250, 500, 1000 and 2000 mg/kg body weight(BW), respectively. Group Ⅴ was used as a control without extract treatment. A toxic symptom was observed by analyzing several parameters, namely change in BW, hematologic and biochemical properties(SGOT & SGPT), macroscopic organs, and relative organ weight. The results showed that there was toxic symptom and statistically significant difference in the parameters of SGOT, SGPT and heart weight between treated and control groups. Based on analysis, we concluded that ethyl acetate extract from endophytic fungus Penicillium sp. of kunyit putih had subchronic toxicity effect.

关键词： subchronic toxicity Endophytic fungi Penicillium sp Curcuma zedoaria

Acute and subchronic toxicity of hydroxylammonium nitrate in Wistar rats

在线全文

学校读者我要写书评

暂无评论

Journal of Medical Colleges of PLA(China) 2008年第3期23卷 137-147页

作者： An Hui Liu Jinyi Yang Lujun Liu Shengxue Zhou Yanhong Yang Huan Jia Qingjun Cui Zhihong Cao Jia Department of Hygienic Toxicology College of Preventive Medicine Third Military Medical University Chongqing 400038 China

Hydroxylammonium nitrate(HAN) is a major constituent in a class of liquid monopropellants and is extensively used in nuclear industry and space *** toxicological studies have focused on oral,inhalation and dermal routes of exposure to HAN-based propellant *** this study,acute and subchronic toxicity of HAN in Wistar rats by intraperitoneal injections were *** this acute study,doses of HAN at 115,125,135,147,160 or 174 mg/kg were *** adverse effects were observed during a 14-day period and at gross histopathological *** the subchronic study,HAN at 7,14 or 28 mg/kg were administered for 13 *** treatment with HAN caused significant changes in the weight of spleen,in the level of hematological parameters,total bilirubin,direct bilirubin,uric acid and carbondioxidecombining power and histopathological damages of the lung,liver,spleen and ***,the study suggests that 13-week HAN treatment caused abnormal hematological changes and tissue lesions,and the risk of toxicity to mammals is not negligible.

关键词： Hydroxylammonium nitrate Acute toxicity subchronic toxicity Wistar rats

Antihyperglycemic and subchronic toxicity study of Moringa stenopetala leaves in mice

在线全文

学校读者我要写书评

暂无评论

Journal of Coastal Life Medicine 2014年第3期 214-221页

作者： Tesemma Sileshi Eyasu Makonnen Asfaw Debella Birhanu Tesfaye Department of Pharmacy College of Medicine and Health ScienceAmbo UniversityPO Box 19AmboEthiopia Addis Ababa University School of MedicinePO Box 9080Addis AbabaEthiopia Ethiopian Nutrition and Health Research Institute(ENHRI) PO Box 1242Addis AbabaEthiopia

Objective:To evaluate the antihyperglycemic activity and subchronic toxicity of an extract ofMoringa stenopetala(***)leaves in ***:Antihyperglycemic activities of various solvent subfractions and chromatographic fractions were investigated in alloxan induced diabetic *** fractions were administered intragastrically using oral gavage at a dose of 500 mg/*** the subchronic toxicity investigation of the 70%ethanol extract of *** leaves,a daily dose of 300 or 600 mg/kg body weight was administered to mice over 96 *** hematological and plasma biochemical parameters were measured as indices of organ specific *** phytochemical screening and antioxidant activity investigation was done using thin layer chromatography ***:Among the solvent subfractions of the 70%ethanol extract tested only butanol subfraction exhibited significant reduction of blood glucose level(Psubchronic toxicity study of the 70%ethanol extract of *** leaves revealed that there were no significant differences in body weight,between controls and treated *** analysis showed no differences in most parameters ***,it did not significantly affect plasma creatinine,urea,cholesterol,triglycerides and CA125 *** also did not significantly affect the plasma T3,T4 and THS ***,however,caused a significant dose-dependent increases in aspartate aminotransferase and alkaline *** p

关键词： Moringa stenopetala Diabetes mellitus Antihyperglycemic effect Mice subchronic toxicity

subchronic Oral toxicity Evaluation of Lanthanum： A 90-day, Repeated Dose Study in Rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2018年第5期31卷 363-375页

作者： FANG Hai Qin YU Zhou ZHI Yuan FANG Jin LIChen Xi WANG Yi Mei PENG Shuang Qing JIA Xu Dongl Key Laboratory of Food Safety Risk Assessment of Ministry of Health China National Center for Food Safety Risk AssessmentBeijing 100021China Evaluation and Research Centre for Toxicology Institute of Disease Control and PreventionAcademy of Military Medical SciencesBeijing 100071China

Objective The present study was undertaken to evaluate the subchronic toxicity of lanthanum and to determine the no observed adverse effect level（NOAEL）,which is a critical factor in the establishment of an acceptable dietary intake（ADI）.Methods In accordance with the Organization for Economic Co-operation and Development（OECD） testing guidelines,lanthanum nitrate was administered once daily by gavage to Sprague-Dawley（SD） rats at dose levels of 0,1.5,6.0,24.0,and 144.0 mg/kg body weight（BW） per day for 90 days,followed by a recovery period of 4 weeks in the 144.0 mg/kg BW per day and normal control *** parameters were mortality,clinical symptoms,body and organ weights,serum chemistry,and food consumption,as well as ophthalmic,urinary,hematologic,and histopathologic *** benchmark dose（BMD） approach was applied to estimate a point of departure for the hazard risk assessment of *** Significant decreases were found in the 144.0 mg/kg BW group in the growth index,including body weight,organ weights,and food *** study suggests that the NOAEL of lanthanum nitrate is 24.0 mg/kg BW per ***,the 95% lower confidence value of the benchmark dose（BMDL） was estimated as 9.4 mg/kg BW per day in females and 19.3 mg/kg BW per day in *** The present subchronic oral exposure toxicity study may provide scientific data for the risk assessment of lanthanum and other rare earth elements（REEs）.

关键词： Lanthanum subchronic toxicity 90-day repeated oral dose test No observed adverse effectLevel Acceptable dietary intake Benchmark dose

Safety assessment of Mequindox:Acute and subchronic toxicity Studies in Wistar Rats

在线全文

学校读者我要写书评

暂无评论

Safety assessment of Mequindox:Acute and Subchronic Toxicity...

subchronic Oral toxicity of Silica Nanoparticles and Silica Microparticles in Rats

中国畜牧兽医学会兽医药理毒理学分会第十次研讨会

作者： Awais Ihsan National Reference Laboratory of Veterinary Drug Residues and MOA Key Laboratory of Food Safety Evaluation Huazhong Agriculture University

Quinoxaline 1,4-dioxide derivatives have been described as interesting biological active compounds reminding its interest in medicinal chemistry until *** animal husbandry,they are used as feed additives to prevent diarrhea and to improve growth. Mequindox(2-Methyl-3 acetyl- quinoxaline-1,4-dioxide) is a new quinoxaline derivative developed by Lanzhou Institute of Animal Husbandry and Veterinary Drugs,Chinese Academy of Agricultural Sciences(China).We have studied the acute and subchronic oral toxicity of Mequindox(MEQ) in male and female Wistar *** acute MEQ doses of 175,550,and 2000 mg/kg body weight dissolved in 0.5%carboxymethyl cellulose were administered by oral *** investigate the subchronic toxicological effects,MEQ was administered in Wistar rats(30/sex/group) for 90-day dietary exposure at doses of 0,55,110 and 275 mg MEQ/kg diet or 110 mg cyadox/kg *** parameters included mortality,clinical signs,body weight,body weight gain,food water consumption,feed conversion efficiency,hematology,clinical chemistry values,oxidative stress parameters(SOD and MDA),organ weights,macroscopic examinations and histopathological *** acute toxicity studies, all the rats were found dead at 2000 mg/kg body weight and one rat was found dead at 550 mg/kg body *** was calculated as 550 mg/kg body weight using the maximum likelihood method by AOT425 statistical *** the sub-chronic study,body weights and feed consumption in the 275 mg/kg MEQ-treated animals of both sexes were significantly suppressed compared to that of the untreated *** groups were unaffected by *** the high dose group,slightly elevated ALT and AST values were observed in male *** toxic effects following administration of 275 mg/kg included change in Na and K electrolytes parameters in both *** oxidative stress parameters,at high dose groups,the levels of thiobarbituric acid reactive substances(TBARS) was increased in males,and

关键词： Acute Feed additives Mequindox NOAEL subchronic toxicity Wistar rats.

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2018年第3期31卷 197-207页

作者： LIANG Chun Lai XIANG Qian CUI Wen Ming FANG Jin SUN Na Na ZHANG Xiao Peng LI Yong Ning YANG Hui YU Zhou JIA Xu Dong Key Laboratory of Food Safety Assessment of Ministry of Health China National Center for Food Safety Risk Assessment Beijing 100021 China Sichuan Province Medical Science Academy & Sichuan Provincial People's Hospital Chengdu 610072 Sichuan China

Objective To investigate the subchronic oral toxicity of silica nanoparticles（NPs） and silica microparticles（MPs） in rats and to compare the difference in toxicity between two particle *** Sprague-Dawley rats were randomly divided into seven groups： the control group; the silica NPs low-, middle-, and high-dose groups; and the silica MPs low-, middle-, and high-dose groups [166.7,500, and 1,500 mg/（kg·bw·day）]. All rats were gavaged daily for 90 days, and deionized water was administered to the control group. Clinical observations were made daily, and body weights and food consumption were determined weekly. Blood samples were collected on day 91 for measurement of hematology and clinical biochemistry. Animals were euthanized for necropsy, and selected organs were weighed and fixed for histological examination. The tissue distribution of silicon in the blood, liver,kidneys, and testis were *** There were no toxicologically significant changes in mortality, clinical signs, body weight,food consumption, necropsy findings, and organ weights. Differences between the silica groups and the control group in some hematological and clinical biochemical values and histopathological findings were not considered treatment related. The tissue distribution of silicon was comparable across all *** Our study demonstrated that neither silica NPs nor silica MPs induced toxicological effects after subchronic oral exposure in rats.

关键词： subchronic toxicity Silica nanoparticles Silica microparticles Rats

subchronic toxicity Study of Epimedii Folium（淫羊藿） Extract in Rat

在线全文

学校读者我要写书评

暂无评论

Subchronic Toxicity Study of Epimedii Folium（淫羊藿） Extra...

subchronic oral toxicity evaluation of ethanolic whole plant extract of Eleucine indica on haematological and biochemical indices in Wistar albino rats

中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛

作者： Sishuo Cao Bolin Fan Yinjing Zhang Jun Du Amway(China) R&D center Hubei Provincial Center for Disease Control and Prevention

Epimedii Folium has been proven to possess efficacy on sexual dysfunction and *** are a lot of single prescription preparations and compound preparations which contain Epimedii Folium approved by China food and drug administration（CFDA） ***,a notification from CFDA reported some adverse effects on a traditional Chinese medicine compound which contain Epimedii Folium.A toxicity study was necessary to make clear whether Epimedii Folium contribte to those adverse *** effects of Epimedii Folium Extract were evaluated in a 90-day subchronic toxicity on Wistar *** groups of 20 Wistar rats were gavaged with water,238,475 or 951mg/kg/day Epimedii Folium extract for *** observations,body weights,feed-intake,hematological and serum biochemical parameters,relative organ weights and gross and microscopic observations were *** obvious toxic effects were observed in this study considered to be test material *** no-observed-adverse-effect-level（NOAEL） of the rats study was determined to be 951 mg/kg BW Epimedii Folium Extract（contained 20%icariin）.

关键词： Epimedii Folium Extract subchronic toxicity rats traditional Chinese medicine

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Coastal Life Medicine 2016年第2期4卷 161-166页

作者： Ette Okon Ettebong Paul Alozie Nwafor Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of UyoUyoNigeria

Objective:To evaluate the effect of ingestion of ethanolic whole plant extract of Eleucine indica on haematological and biochemical parameters of Wistar albino ***:subchronic toxicity study was carried out by oral administration of different doses(200,400 and 600 mg/kg body weight)of the extract on alternate-day basis to different groups of rats for 28 *** animals were subsequently sacrificed and blood samples were collected by cardiac puncture for haematological and biochemical ***:Haematological indices were preserved and the extract showed significant(P<0.01–0.001)haemostatic *** was significant reduction(P<0.05–0.001)in total bilirubin,aspartate aminotransferase(P<0.001),alanine transaminase(P<0.05),alkaline phosphatase(P<0.001)and blood glucose(P<0.001)compared to *** level of total protein increased significantly(P<0.05–0.001).Kidney functions were,however,***:The results obtained indicated that ingestion of Eleucine indica whole plant extract for a long period of time reduces both bleeding and clotting times,reduces blood sugar and shows no apparent toxic effect on liver and *** results of this study may be useful as a basis for clinical trials in humans.

关键词： subchronic toxicity Wistar rats Eleucine indica Whole plant extract