Acute and subchronic toxicity of hydroxylammonium nitrate in Wistar rats

作     者：An Hui Liu Jinyi Yang Lujun Liu Shengxue Zhou Yanhong Yang Huan Jia Qingjun Cui Zhihong Cao Jia 

作者机构：Department of Hygienic Toxicology College of Preventive Medicine Third Military Medical University Chongqing 400038 China 

出 版 物：《Journal of Medical Colleges of PLA(China)》 (中国人民解放军军医大学学报（英文版）)

年 卷 期：2008年第23卷第3期

页      面：137-147页

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

基　　金：the Scientific Research Foundation for Medica Science and Public Health of PLA (06z032) 

主　　题：Hydroxylammonium nitrate Acute toxicity Subchronic toxicity Wistar rats 

摘      要：Hydroxylammonium nitrate(HAN) is a major constituent in a class of liquid monopropellants and is extensively used in nuclear industry and space *** toxicological studies have focused on oral,inhalation and dermal routes of exposure to HAN-based propellant *** this study,acute and subchronic toxicity of HAN in Wistar rats by intraperitoneal injections were *** this acute study,doses of HAN at 115,125,135,147,160 or 174 mg/kg were *** adverse effects were observed during a 14-day period and at gross histopathological *** the subchronic study,HAN at 7,14 or 28 mg/kg were administered for 13 *** treatment with HAN caused significant changes in the weight of spleen,in the level of hematological parameters,total bilirubin,direct bilirubin,uric acid and carbondioxidecombining power and histopathological damages of the lung,liver,spleen and ***,the study suggests that 13-week HAN treatment caused abnormal hematological changes and tissue lesions,and the risk of toxicity to mammals is not negligible.