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Comprehensive pathogenesis and clinical therapy in striae distensae: An overview and current perspective

Chinese Journal Of Plastic and Reconstructive Surgery 2022年第4期4卷 203-207页

作者： Yichen Shen Qianqian Pang Jinghong Xu Department of Plastic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003ZhejiangChina Department of Plastic Surgery Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010ZhejiangChina

The pathogenesis of striae distensae(SD) is complicated and has not yet been fully elucidated. Hormonal changes,overstretched skin, and structural and functional changes in the skin may be crucial factors in the development of SD. Therapy aims to stimulate dermal collagen synthesis and improve skin texture. Mainstream treatments include topical medications, chemical peeling, laser and radiofrequency therapy, microdermabrasion, microneedle therapy, and filler injection therapy. In the present review, we summarize current perspectives on the pathogenesis and clinical therapy of SD.

关键词： striae distensae Pathogenesis Clinical therapy

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Effects of Semi-Ablative Fractional Radiofrequency Associated with Growth Factors in Stretch Marks: A Randomized Controlled Trial

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Open Journal of Applied Sciences 2021年第4期10卷 379-394页

作者： Patricia F. Meyer Rodrigo Marcel V. Da Silva Liliane S. Vasconcelos Louhanne Christine B. Bezerra Maria Paula M. Oliveira Eneida M. Carreiro Ciro D. Soares Fabio S. Borges Monica Etrusco Joyce Rodrigues Silene B. Ribeiro Hernan Andrés B. Ortiz Federal University of Rio Grande do Norte (UFRN) Natal Brazil Physiotherapy Course at UNIRN Natal Brazil Mauricio de Nassau Natal Natal Brazil Physiotherapy Course at Potiguar University (UnP) Natal Brazil Potiguar University (UnP) Natal Brazil Graduate Program in Stomatopathology State University of Campinas S&#227 o Paulo Brazil Postgraduate Program in Dermatofunctional Physiotherapy Estácio de Sá University Rio de Janeiro Brazil Minas Gerais Faculty of Medical Sciences Minas Gerais Brazil Sã o Judas Tadeu University Butant&#227 Brazil FSG Centro Universitário Caxias do Sul Brazil Physiotherapy Course Escuela de Kinesiología Facultad de Ciencias de la Rehabilitación Universidad Andrés Bello Santiago Chile

Background: To investigate the effects of the association of semi-ablative fractional radiofrequency (RFF) with growth factors in stretch marks. Methods: This is a randomized controlled trial. The sample consisted of 28 female patients with complaints of gluteus or abdomen striae and divided into 2 equitable groups, named G1 (semi-ablative RFF without active principle association) and G2 (semi-ablative RFF with active principle association), being subdivided into G-1A and G-2A (abdominal applications) and G-1B and G-2B (gluteus applications). A photographic and histological analysis was performed using questionnaires about inflammation, presence of adverse effects and satisfaction of volunteers. Photographic analysis showed a reduction in the amount of striae alba in all groups. Results: The histological analysis showed an increase in fibroblast activity, collagen type I, and blood vessels, especially in the groups that associated the RFF with the active principle. In the inflammation analysis, the groups that performed intervention with active ingredients showed lower inflammatory signal. All groups had a reasonable level of satisfaction after the interventions;however, the group that used active ingredients reported greater results. Conclusion: The association of semi ablative RFF with growth factors showed a reduction in clinical inflammatory signs, mainly in the first 15 days, as well as higher collagen production, verified in 30 days, with satisfactory clinical results in all groups.

关键词： striae distensae Collagen Wound Healing

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