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Fabrication of anti-fouling polyamide nanofiltration membrane by incorporating streptomycin as a novel co-monomer

Chinese Journal of Chemical Engineering 2022年第10期50卷 185-196页

作者： Shujie Guo Jiao Du Fangzheng Yan Zhi Wang Jixiao Wang Chemical Engineering Research Center School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Tianjin Key Laboratory of Membrane Science and Desalination Technology State Key Laboratory of Chemical EngineeringCollaborative Innovation Center of Chemical Science and EngineeringTianjin UniversityTianjin 300350China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300350China

Polyamide(PA)thin-film composite(TFC)na nofiltration(NF)membrane has extremely broad application prospects in separation of monovalent/diva lent inorganic salts mixed solutio ***,membrane fouling is the main obstacle to the application of PA,TFC and NF ***(SM)is a hydrophilic antibiotic containing a large number of hydroxyl and amino *** this work,the NF membrane was prepared via interfacial polymerization(IP)between trimesoyl chloride(TMC)in the organic phase and SM/piperazine(PIP)mixture in the aqueous *** NF membrane structure and performance were characterized in *** results showed that SM successfully participated in the *** negative charge and hydrophilicity of membrane surface were *** prepared membrane exhibited good anti-adhesion and anti-bacterial performance,Additionally,when the SM concentration was 2%,the prepared membrane exhibited the optimal *** water permeance was 89.4L·m^(-2)·h^(-1)·MPa^(-1).The rejection of NaCl and Na_(2)SO_(4) were 17,17%and 97.84%,*** NaCl/Na_(3)SO_(4) separation factor of the SM2-PIP/TMC membrane in 1000 mg·L^(-1) NaCl and 1000 mg·L^(-1)Na_(2)SO_(4) mixed solution was 40,which was 3.3 times that of PIP/TMC *** indicated that SM2-PIP/TMC demonstrated excellent monovalent/divalent salts separation *** work provided an easy and effective approach to preparing anti-fouling NF membrane while possessing superior monovalent/divalent salts separation performance.

关键词： streptomycin Polyamide Nanofiltration membrane Anti-adhesion Anti-bacterial

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Bi/BiVO_(4)/NiFe-LDH heterostructures with enhanced photoelectrochemical performance for streptomycin detection

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Journal of Environmental Sciences 2021年第11期33卷 114-122页

作者： Liqin Yang Jun Zhao Caijun Wang Zheng Wang Cuijuan Xing Hao Guo Yuman Wang Zhiju Zhao Zhangji Hu Zhenyu Cai College of Chemistry and Chemical Engineering Xingtai UniversityXingtai 054001China School of Physics and Electronic Engineering Xingtai UniversityXingtai 054001China Xingtai University Xingtai 054001China

streptomycin(STR)plays an essential role in bacterial infection *** and sensitivity of photoelectrochemical(PEC)sensors are the two most important parameters,which can be measured using the photosensitivity of its active *** prepared a novel PEC sensor to detect STR using Bi/BiVO4/LDH(layered double hydroxides)heterostructures as an active material,which is photoactive in the visible light wavelength *** simultaneous presence of LDH and Bi/BiVO4 enhanced the material photocurrent response,which was linear to the STR concentrations in the 0.01–500 nmol/L *** STR detection limit by this sensor was 0.0042 nmol/*** novel PEC-based sensing strategy includes using an ultra-sensitive and highly selective sensor for STR ***,the two-pot synthesis of Bi/BiVO4/LDH developed in this work is environmentally friendly.

关键词： Bi/BiVO4/LDH(layered double hydroxides) Detection Heterojunction Photoelectrochemical sensor streptomycin

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Monoclonal antibody-based ELISA and colloidal gold-based immunochromatographic assay for streptomycin residue detection in milk and swine urine

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第1期11卷 52-60页

作者： Jian-xiang WU Shao-en ZHANG Xue-ping ZHOU Institute of Biotechnology Zhejiang University Hangzhou 310029 China Nankai Biotechnology Limited Company Hangzhou 310051 China

A protein conjugate of streptomycin （streptomycin-bovine serum albumin （BSA） conjugate） was prepared and used as immunogen to produce monoclonal antibodies （MAb）. One hybridoma secreting anti-streptomycin MAb was obtained and then used to produce MAb. The MAb named 13H5 showed the 50% maximal inhibitory concentra- tion （IC50） value of 4.65 ng/ml and the IC20value of 0.21 ng/ml in phosphate buffered saline （PBS）. At optimum con- ditions, an indirect competitive enzyme-linked immunosorbent assay （ELISA） and a colloidal gold-based immuno- chromatographic assay （CGIA） were developed and applied to detect streptomycin residues in milk and swine urine samples. The developed ELISA showed that the minimum detection limit was 2.0 and 1.9 ng/ml for milk and swine urine samples, respectively, without obvious cross-reactivity to other tested antibiotics except dihydrostreptomycin which gave a 118.32% cross reaction value. Milk and swine urine samples spiked with streptomycin at 10, 50, 100 and 200 ng/rnl were analyzed by the established ELISA. The mean recovery of streptomycin was from 81.9% to 105.5% and from 84.3% to 92.2% for milk and swine urine, respectively. The optimized CGIA showed that the minimum de- tection limit was 20.0 ng/ml for milk and swine urine samples. The results of spiked analysis and specific analysis demonstrate that the CGIA could be applicable for screening milk and swine urine samples for the presence of streptomycin residues on-site. The established ELISA and CGIA allow the rapid, low-cost, and sensitive determination of streptomycin residues in food samples.

关键词： streptomycin Monoclonal antibody Antibiotic residue Enzyme-linked immunosorbent assay (ELISA) Colloidal gold-based immunochromatographic assay (CGIA)

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An Aptamer-based Colorimetric Sensor for streptomycin and Its Application in Food Inspection

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Chemical Research in Chinese Universities 2017年第5期33卷 714-720页

作者： LIU Zhongcheng ZHANG Yanfen XIE Yao SUN Ying BI Kewei CUI Zhe ZHAO Lijian FAN Wufang College of Life Sciences Hebei University Baoding 071002 P. R. China Key Laboratory of Pharmaceutical Quality Control of Hebei Province Baoding 071002 P. R. China Office of Science and Technology Hebei University Baoding 071002 P. R. China

An aptamer-based colorimetric biosensor was developed, which could be used to detect residual strepto- mycin from food quickly and cost-effectively. The ssDNA aptamer target for streptomycin was obtained using sys- temic evolution of ligands by exponential enrichment through affinity chromatography. A total of 19 candidates were obtained after 10 rounds of selection and were grouped into 3 families according to their similarity of sequence and structure. Among them, aptamer A15 showed the highest affinity for streptomycin tested by fluorescence intensity analysis with a dissociation constant of 6.07 nmol/L. Aptamer A15 also exhibited a higher streptomycin specificity with the lowest detectable limit of 25 nmol/L according to the value of A620/A520 ratio with AuNP-based colorimetric assay. The method was specific and sensitive for the detection of streptomycin from simply-treated milk and honey at 100 and 125 nmol/L, respectively, and is a promising approach to monitor antibiotics or other small molecules ana- logues in food inspection.

关键词： Aptamer streptomycin Systematic evolution of ligands by exponential enrichment(SELEX) Au nanopar- ticle Aptasensor

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streptomycin inhibits electrophysiological changes induced by stretching of chronically infarcted rat hearts

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第6期15卷 515-521页

作者： Jun-xian CAO Lu FU Qian-ping GAO Rong-sheng XIE Fan QU Department of Cardiology the First Affiliated Hospital of Harbin Medical University Department of Chinese Medicine Women's Hospital School of Medicine Zhejiang University

Objective： To investigate stretch-induced electrophysiological changes in chronically infarcted hearts and the effect of streptomycin （SM） on these changes in vivo. Methods： Sixty Wistar rats were divided randomly into four groups： a control group （n=15）, an SM group （n=15）, a myocardial infarction （MI） group （n=15）, and an MI＋SM group （n=15）. Chronic MI was obtained by ligating the left anterior descending branch （LAD） of rat hearts for eight weeks. The in vivo blockade of stretch-activated ion channels （SACs） was achieved by intramuscular injection of SM （180 mg/（kg·d）） for seven days after operation. The hearts were stretched for 5 s by occlusion of the aortic arch. Suction electrodes were placed on the anterior wall of left ventricle to record the monophasic action potential （MAP）. The effect of stretching was examined by assessing the 90% monophasic action potential duration （MAPD90）, premature ventricular beats （PVBs）, and ventricular tachycardia （VT）. Results： The MAPD90 decreased during stretching in both the control （from （50.27±5.61） ms to （46.27±4.51） ms, P〈0.05） and MI groups （from （65.47±6.38） ms to （57.47±5.76 ms）, P〈0.01 ）. SM inhibited the decrease in MAPD90 during inflation （（46.27±4.51） ms vs. （49.53±3.52） ms, P〈0.05 in normal hearts; （57.47±5.76） ms vs. （61.87±5.33） ms, P〈0.05 in MI hearts）. The occurrence of PVBs and VT in the MI group increased compared with that in the control group （PVB： 7.93±1.66 vs. 1.80±0.86, P〈0.01; VT： 7 vs. 1, P〈0.05）. SM decreased the occurrence of PVBs in both normal and MI hearts （0.93±0.59 vs. 1.80±0.86 in normal hearts, P〈0.05; 5.40±1.18 vs. 7.93±1.66 in MI hearts, P〈0.01）. Conclusions： Stretch-induced MAPD90 changes and arrhythmias were observed in chronically infarcted myocardium. The use of SM in vivo decreased the incidence of PVBs but not of VT. This suggests that SACs may be involved in mechanoelectric feedback （MEF）, but that there might be other mechanisms involved in causing VT in chronic MI.

关键词： Arrhythmia Mechanoelectric feedback Monophasic action potential Myocardial infarction streptomycin

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A comparative study of adsorption behavior of rifampicin,streptomycin,and ibuprofen contaminants from aqueous solutions onto chitosan:Dynamic interactions,kinetics,diffusions,and mechanisms

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Emerging Contaminants 2023年第1期9卷 20-32页

作者： Ensan Waatriah E.S.Shahrin Nur Alimatul Hakimah Narudin Nurulizzatul Ningsheh MShahri Muhammad Nur Jun-Wei Lim Muhammad Roil Bilad Abdul Hanif Mahadi Jonathan Hobley Anwar Usman Department of Chemistry Faculty of ScienceUniversiti Brunei DarussalamJalan Tungku LinkGadongBE1410Brunei Darussalam Center for Plasma Research Integrated LaboratoryUniversitas DiponegoroTembalangSemarang50275Indonesia HICoE-Centre for Biofuel and Biochemical Research Institute of Self-Sustainable BuildingDepartment of Fundamental and Applied SciencesUniversiti Teknologi PETRONAS32610Seri IskandarPerak Darul RidzuanMalaysia Faculty of Integrated Technologies Jalan Tungku LinkGadongBE1410Brunei Darussalam Centre for Advanced Material and Energy Sciences Universiti Brunei DarussalamJalan Tungku LinkGadongBE1410Brunei Darussalam Department of Biomedical Engineering National Cheng Kung UniversityNo.1 University RoadTainan City 701Taiwan

Adsorptive removal and dynamic interaction of three different pharmaceutical pollutants,namely rifampicin(RIF),streptomycin(STM),and ibuprofen(IBU)onto chitosan were systematically investigated using a batch adsorption technique at different processing *** this study,chitosan was derived from mud-crab shells,as an innovative way to use the waste from marine foods as *** kinetics,intraparticle diffusion,mechanism,and thermodynamics of the adsorption were systematically evaluated and analyzed using kinetic models,Boyd mass transfer and WebereMorris intraparticle diffusion models,Langmuir,Freundlich,DubinineRadushkevich,and Temkin isotherm models,and the Gibbs *** adsorption isotherm of the larger molecules,RIF and STM,could be explained by the Langmuir isotherm model,in contrast,that of IBU,which is a much smaller molecule,followed the Freundlich isotherm *** maximum adsorption capacity of RIF,STM,and IBU on chitosan was estimated to be 66.91 mg g^(-1),11.00 mg g^(-1),and 24.21 mg g^(-1),respectively,which are higher compared to those on a variety of agricultural wastes,suggesting that this biopolymer is a potential practical and economical adsorbent to remove the pharmaceutical compounds from *** adsorption mechanism of the pharmaceutical compounds on chitosan is proposed based on the vibrational spectroscopic analyses,XRD patterns,and DSC thermograms of the biopolymer before and after adsorption process.

关键词： Adsorption Rifampicin streptomycin Ibuprofen Chitosan Mud-carb shells

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Molecular Docking Studies on streptomycin Antileishmanial Activity

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Open Journal of Physical Chemistry 2024年第2期14卷 36-48页

作者： Todd A. Young Matthew George Jr. Ayele Gugssa William M. Southerland Yayin Fang Clarence M. Lee Department of Biology Howard University Washington DC United States Department of Biochemistry and Molecular Biology Howard University Washington DC United States

Resistance to pentavalent antimonial drugs and the lack of vaccines make it urgent to find novel therapeutic options to treat Leishmaniasis, a tropical disease caused by the Leishmania protozoan parasite. The study reported here is to investigate if streptomycin, an aminoglycoside, and Amphotericin B, the second-line treatment drug, exhibit antileishmanial activity through a similar mechanism. By using MOE (Molecular Operating Environment), we performed molecular docking studies on these drugs binding to a range of targets including ribosome targets in Leishmania and H. sapiens. Our study shows that the two drugs do not bind to the same pockets in Leishmania targets but to the same pockets in the human ribosome, with some differences in interactions. Moreover, our 2D maps indicated that Amphotericin B binds to the A-site in the human cytoplasmic ribosome, whereas streptomycin does not.

关键词： Leishmaniasis streptomycin Amphotericin B Molecular Docking Aminoglycosides Antileishmanial

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Pharmacokinetic Disposition of streptomycin Sulfate in Japanese Eel (<i>Anguilla japonica</i>) after Oral and Intramuscular Administrations

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Pharmacology & Pharmacy 2012年第2期3卷 195-200页

作者： Ping He Jin-Yu Shen Wen-Lin Yin Jia-Yun Yao Yang Xu Xiao-Yi Pan Gui-Jie Hao Zhejiang Institute of Freshwater Fisheries Huzhou China

Pharmacokinetics and residue elimination of streptomycin sulfate (STR) are important in the determination of optimal dosage regimens and in establishing safe withdrawal periods in farmed fishes. The pharmacokinetics of STR was studied after a single dose (50 mg/kg) of intramuscular (i.m.) or oral gavage (p.o.) administration to Japanese eel (Anguilla japonica) in freshwater at 25°C. Eight fish per sampling point were examined after treatment. Plasma and muscle were collected and analyzed by high-performance liquid chromatography (HPLC) method with 0.05 μg/ml detection limit. The data of pharmacokinetics conformed to the two-compartment open model for intramuscular and one-compartment open model for oral administrations. After intramuscular administration, the elimination half-life (t1/2β) was calculated to be 11.346 h, the maximum plasma concentration (Cmax) to be 29.524 μg/ml, the time to peak plasma streptomycin concentration (Tmax) to be 0.218 h, and the area under the plasma concentration-time curve (AUC) to be 90.206 μg/ml?h. Following p.o. administration, the corresponding estimates were 13.239 h, 0.346 μg/ml, 11.960 h, and 12.356 μg/ml?h. After intramuscular administration, a therapeutic concentration of the drug was maintained for 12 hours in the plasma, however, a therapeutic level could not be achieved after oral administration, and the results suggest that the drug can be used clinically by intramuscular administration against streptomycin susceptible systemic infections in Japanese eel.

关键词： Pharmacokinetic streptomycin Sulfate Japanese Eel Intramuscular Oral Gavage

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The Use of the PCR-Based Dot-Blot Hybridization Assay to Detect Resistance Markers to Rifampicin and streptomycin in Mycobacterium tuberculosis Isolates from the SW Region of Cameroon

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Journal of Tuberculosis Research 2016年第2期4卷 72-79页

作者： Irene Ane-Anyangwe Wilfred Fon Mbacham Henry Dilonga Meriki Teyim Pride Theresa Nkuo-Akenji Veronique Mbeng Penlap Leopold Djomkam Tietcheu Damian Nota Anong Akindeh Mbuh Nji Vincent P. K. Titanji Department of Biochemistry and Microbiology Faculty of Science University of Buea Buea Cameroon Laboratory for Public Health Research Biotechnologies Biotechnology Centre University of Yaoundé Yaoundé Cameroon Mezam Polyclinic Bamenda Cameroon

Drug sensitivity testing to establish resistance to TB drugs takes many months to arrive at. Public health physicians have difficulties with such an approach due to long wait periods and cannot use it to establish community wide prevalence as a way to understand where resistance may be emerging faster and to limit its spread. The objective of this study was to use the dot-blot hybridization technique in the detection of resistance to rifamycin (RIF) and streptomycin (SM) in South- Western Cameroon and to compare the technique with the routine culture and drug susceptibility testing for detecting resistance in a resource poor country, Cameroon. A hospital-based study was conducted at the Regional hospitals of Buea and Limbe and Tiko Central Clinic. Tuberculosis (TB) patients aged 15 to 50 (mean age: 30.50 ± 8.33 standard deviation) were recruited for the study between December 2006 and April 2007. Cultures from 59 patients were tested for rifampicin and streptomycin sensitivity by the modified proportion method and mutational analysis for rpoB codon 516 and rrs codon 513 was performed by the dot-blot hybridization technique. Of the 59 sputum samples collected (36 were males and 23 were females) came from Buea 19 (32.2%), Limbe 20 (33.9%) and Tiko 20 (33.9%) towns respectively. Amplification for the gene showed that there was (59) 100% amplification with primers used for rpoB genes and 43 (72.9%) amplification with primers used for the rrs gene. Mutational analysis demonstrated that resistance to RIF was common in females (52.1%) than males (41.7%) while 6% of the samples were indeterminate. 12 (20.3%) samples showed phenotypic and genotypic resistance to RIF compared to 34 samples (58.1%) for SM. Phenotypic resistance and genotypic susceptibility were found in 5 (8.5%) RIF and 3 (4.7%) SM compared to phenotypic susceptibility and genotypic resistance that were found in 2 (3.5%) RIF and 3(4.7%) SM. Double mutation on rpoB and rrs genes occurred in 8 (13.6%) DNA sample

关键词： PCR-Based DOT-Blot Analysis Rifamycin streptomycin SW Region

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Screening for Streptomyces Hygroscopicus Strains with High Production of Agricultural Antibiotics by streptomycin Resistance

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Agricultural Science & Technology 2008年第1期9卷 146-149页

作者：彭祎黄永春蔡延明曹仁林农业部环境保护科研监测所

[Objective] The research aimed to screen Streptomyces hygroscopicus strains with high production of agricultural antibiotics. [ Method] A strain of S. hygroscopicus was screened from the soil of Hainan Island. After natural screening and consecutive ultraviolet induced mutation twice, S6-7 strain was obtained as the original strain then treated by UV irradiation and streptomycin resistance screening, and finally rescreened through shake-flask fermentation. [Result] 7 better strains were selected by primary screening from 62 single colonies which were picked out randomly. After 3 generations of consecutive cultivation on slant media and rescreening, 5 strains presented obvious forward mutation. The forward mutation rate reached 8.06%, and the largest production increasing rate came up to 25.11%. [Conclusion] By combining streptomycin resistance screening and conventional ultraviolet induced mutation, both the antibiotic-producing capacity and forward mutation screening efficiency of the original strain were greatly enhanced.

关键词： Streptomyces hygroscopicus Agricultural antibiotics Ultraviolet induced mutation streptomycin

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