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Anti-glaucoma potential of Heliotropium indicum Linn in experimentally-induced glaucoma

Eye and Vision 2015年第1期2卷 162-169页

作者： Samuel Kyei George Asumeng Koffuor Paul Ramkissoon Osei Owusu-Afriyie Discipline of Optometry School of Health SciencesCollege of Health SciencesUniversity of KwaZulu-NatalDurbanSouth Africa Department of Optometry School of Physical SciencesUniversity of Cape-CoastCape-CoastGhana Department of Pharmacology Faculty of Pharmacy and Pharmaceutical SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Pathology Komfo Anokye Teaching HospitalKumasiGhana

Background:Heliotropium indicum is used as a traditional remedy for hypertension in *** aim of the study was to evaluate the anti-glaucoma potential of an aqueous whole plant extract of *** to manage experimentally-induced ***:The percentage change in intraocular pressure(IOP),after inducing acute glaucoma(15 mLkg^(−1) of 5%dextrose,i.v.),in New Zealand White rabbits pretreated with Heliotropium indicum aqueous extract(HIE)(30–300 mgkg^(−1)),acetazolamide(5 mgkg^(−1)),and normal saline(10 mLkg^(−1))per os were *** were also monitored in chronic glaucoma in rabbits(induced by 1%prednisolone acetate drops,12 hourly for 21 days)after treatments with the same doses of HIE,acetazolamide,and normal saline for 2 *** anti-oxidant property of the extract was assessed by assaying for glutathione levels in the aqueous *** concentration in the vitreous humour was also determined using ELISA *** assessment of the ciliary bodies was ***:The extract significantly reduced intraocular pressure(p≤0.05–0.001)in acute and chronic glaucoma,preserved glutathione levels and glutamate concentration(p≤0.01–0.001).Histological assessment of the ciliary body showed a decrease in inflammatory infiltration in the extract and acetazolamide-treated group compared with the normal saline-treated ***:The aqueous whole plant extract of Heliotropium indicum has ocular hypotensive,anti-oxidant and possible neuro-protective effects,which therefore underscore its plausible utility as an anti-glaucoma drug with further investigation.

关键词： Glutathione assay steroid-induced glaucoma Acetazolamide New Zealand white rabbit Anti-glaucoma drug Glutamate

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Expression profile analysis to identify potential gene changes induced by dexamethasone in the trabecular meshwork

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1240-1248页

作者： Miao Wei Lu-Ming Chen Ze-Yu Huang Guo-Wei Zhang Huai-Jin Guan Min Ji Eye Institute Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Dalian Medical University Dalian 116000Liaoning ProvinceChina

AIM:To investigate potential gene changes in trabecular meshwork(TM)induced by dexamethasone(DEX)in steroidinduced glaucoma(SIG).METHODS:The expression data of 24 cases from a public functional genomics data were sorted to identify the mechanisms of action of DEX on the *** relationships of the differentially expressed genes(DEGs)were enriched using Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)*** addition,the hub genes were screened by the Search Tool for the Retrieval of Interacting Genes Database(STRING)and Cytoscape ***,human TM cells(HTMCs)were treated with DEX to preliminarily explore the function of hub ***:Totally 47 DEGs,including 21 downregulated and 26 upregulated genes were *** primary enriched results of the DEGs consisted of inflammatory response,extracellular matrix(ECM),negative regulation of cell proliferation,TNF signalling pathway and the regulation of tr yptophan channels by inflammator y ***,pro-melanin-enriched hormone(PMCH)and Bradykinin B1 receptor(BDKRB1)were screened as hub *** is verified in GSE37474 data *** blot and quantitative real-time polymerase chain reaction(q PCR)results showed that protein and RNA expression levels of BDKRB1 were significantly decreased after DEX treatment,while PMCH was not significantly ***:BDKRB1 may be a key gene involved in SIG onset,providing a suitable therapeutic target for improving the prognosis of SIG patients.

关键词： dexamethasone trabecular meshwork cells steroid-induced glaucoma differentially expressed genes protein-protein interaction

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glaucoma secondary to systemic lupus erythematosus

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Chinese Medical Journal 2014年第19期127卷 3428-3431页

作者： Zhang Jing Huang Wenbin Gao Xinbo Che Huixin Yu Keming Zhang Xiulan Zhongshan Ophthalmic Center State Key Laboratory ofOphthalmology Sun Yat-Sen University Guangzhou Guangdong510060 China Third Affiliated Hospital of Liaoning Medical College JinzhouLiaoning 121001 China glaucoma Department Clinical Research Center Institution of DrugClinical Trials State Key Laboratory of Ophthalmology Sun Yat-senUniversity Guangzhou Guandong 510060 China

Background glaucoma secondary to systemic lupus erythematosus （SLE - an uncommon but serious complication that threatens vision and therefore cannot be neglected. A few cases of second, y glaucoma resulting from lupus-induced or iatrogenic ocular impairments have been reported in association with SLE. However, a systematic analysis of the diagnosis and treatment of glaucoma secondary to SLE has not been reported in the literature. The aim of this study is to further investigate the relationship between glaucoma and SLE. Methods In this study, we reviewed nine eyes of five patients diagnosed with secondary glaucoma associated with SLE, including one case of neovascular glaucoma and four cases of steroid-induced glaucoma. Results Neovascular glaucoma was successfully treated by Ahmed glaucoma valve implantation surgery with adjunctive ranibizumab intravitreal injection, followed by panretinal photocoagulation （PRP）. The steroid-induced glaucoma in eight eyes of four cases were controlled by trabeculectomy along with antiproliferative agents. Conclusion Regular follow-up ocular examinations should be conducted to ensure early diagnosis and treatment of secondary glaucoma in SLE patients to improve the prognosis of vision.

关键词： systemic lupus erythematosus neovascular glaucoma steroid-induced glaucoma

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