Anti-glaucoma potential of Heliotropium indicum Linn in experimentally-induced glaucoma
作者机构：Discipline of OptometrySchool of Health SciencesCollege of Health SciencesUniversity of KwaZulu-NatalDurbanSouth Africa Department of OptometrySchool of Physical SciencesUniversity of Cape-CoastCape-CoastGhana Department of PharmacologyFaculty of Pharmacy and Pharmaceutical SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of PathologyKomfo Anokye Teaching HospitalKumasiGhana
出 版 物：《Eye and Vision》 (眼视光学杂志（英文）)
年 卷 期：2015年第2卷第1期
页 面：162-169页
核心收录：
学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 08[工学]
主 题：Glutathione assay Steroid-induced glaucoma Acetazolamide New Zealand white rabbit Anti-glaucoma drug Glutamate
摘 要：Background:Heliotropium indicum is used as a traditional remedy for hypertension in *** aim of the study was to evaluate the anti-glaucoma potential of an aqueous whole plant extract of *** to manage experimentally-induced ***:The percentage change in intraocular pressure(IOP),after inducing acute glaucoma(15 mLkg^(−1) of 5%dextrose,i.v.),in New Zealand White rabbits pretreated with Heliotropium indicum aqueous extract(HIE)(30–300 mgkg^(−1)),acetazolamide(5 mgkg^(−1)),and normal saline(10 mLkg^(−1))per os were *** were also monitored in chronic glaucoma in rabbits(induced by 1%prednisolone acetate drops,12 hourly for 21 days)after treatments with the same doses of HIE,acetazolamide,and normal saline for 2 *** anti-oxidant property of the extract was assessed by assaying for glutathione levels in the aqueous *** concentration in the vitreous humour was also determined using ELISA *** assessment of the ciliary bodies was ***:The extract significantly reduced intraocular pressure(p≤0.05–0.001)in acute and chronic glaucoma,preserved glutathione levels and glutamate concentration(p≤0.01–0.001).Histological assessment of the ciliary body showed a decrease in inflammatory infiltration in the extract and acetazolamide-treated group compared with the normal saline-treated ***:The aqueous whole plant extract of Heliotropium indicum has ocular hypotensive,anti-oxidant and possible neuro-protective effects,which therefore underscore its plausible utility as an anti-glaucoma drug with further investigation.
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