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Reference values for selected hematological, biochemical and physiological parameters of sprague‐dawley rats at the Animal House, Faculty of Medicine, University of Colombo,Sri Lanka

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Animal Models and Experimental Medicine 2018年第4期1卷 250-254页

作者： Shehani L.Delwatta Mangala Gunatilake Vera Baumans Melanie D.Seneviratne Manjula L.B.Dissanayaka Siyani S.Batagoda Asanga H.Udagedara Prasad B.Walpola Faculty of Medical Sciences University of Sri Jayawardanepura Faculty of Medicine University of Colombo Division of Laboratory Animal Science Utrecht University

Background: Lack of available reference values in a research setting under local conditions can be a drawback for beginners, as the accuracy of data from control samples cannot be checked at the beginning of a research project. This affects comparisons with data from test samples. To avoid these complications in their research projects,beginners tend to have a greater number of animals in the control group compared to test groups in order to have control group measurements within 2 SDs of the ***: As non-availability of reference values was a long-felt need, the described project was conducted in order to establish a reference database for selected haematological, biochemical and physiological parameters using apparently healthy sprague-dawley rats bred in the Animal House of Faculty of Medicine, University of Colombo(UCFM).Results: Differences in mean values of packed cell volume(PCV), mean corpuscular volume(MCV) and mean corpuscular hemoglobin concentration(MCHC), serum creatinine and blood glucose levels between the two genders were statistically significant. Lipid profile measurements did not differ significantly between genders, but mean and median values of triglycerides(TG) between male and female rats showed a difference of more than 10 mg/dL. The liver enzymes alkaline phosphatase(AP)and aspartate aminotransferase(AST) were also statistically significantly different between sexes. Despite wide variation in mean alanine aminotransferase(ALT)between sexes, the difference was not statistically ***: The findings of this project should support to a certain extent the"Reduction" aspect of the 3 Rs concept of Russell and Burch by reducing the number of sprague-dawley rats used in future research projects at UCFM.

关键词： 3Rs concept rat reference values sprague-dawley

维普期刊数据库

Analysis of Behaviour Pattern in sprague-dawley Rats Using Microwave Techniques

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Journal of Electromagnetic Analysis and Applications 2017年第11期9卷 155-166页

作者： Anil Lonappan Ernest Remy Hervé Ebell’a Dallé Thomas Joachim Odhiambo Afullo Williams Mark Uren Daniels Department of Electrical Engineering Mangosuthu University of Technology Durban South Africa College of Health Sciences School of Laboratory Medicine and Medical Sciences University of KwaZulu-Natal Durban South Africa School of Electrical Electronic and Computer Engineering Howard College University of KwaZulu-Natal Durban South Africa

This communication presents a new method of detecting the behaviour pattern in sprague-dawley (SD) rats based on the measurement of the dielectric properties of blood plasma at microwave frequencies at different periods of time. The microwave measurements were performed by rectangular cavity perturbation method in the S-band of microwave frequency with the blood plasma collected from normal rats (Controls) as well as chemically induced rats (Aβ). A change is observed in the dielectric properties of the Aβsamples but not the controls samples at the extended period of time. This measurement technique is simple and the collection of blood from the rats is nonsurgical in nature. These results prove a new method of diagnosing Alzheimer’s Disease (AD) using microwave techniques.

关键词： Blood Plasma sprague-dawley Rats Cavity Perturbation Alzheimer’s Disease

Outer hair cells isolation from postnatal sprague-dawley rats

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 14-18页

作者： Mei-Hao Qi Yang Qiu Ke-Yong Tian Kun Liang Hui-Min Chang Ren-Feng Wang Er-Fang Chen Wei-Long Wang Ding-Jun Zha Jian-Hua Qiu Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalFourth Military Medical UniversityXi'anPR China Department of Otorhinolaryngology Head and Neck Surgery Tangdu HospitalFourth Military Medical UniversityXi'anPR China

Outer hair cells (OHCs) damage is a general phenomenon in clinical disorders such as noise-induced hearing loss and drug-induced hearing *** order to elucidate the mechanism underlying these disorders,OHCs-its diseased region needs to be deeply ***,OHCs array on the basilar membrane which contains massive cells with different ***,to isolate OHCs from this huge population is significant for revealing its pathological and molecular changes during disease *** the present study,we tried to isolate OHCs from the commonly used animal model-sprague-dawley (SD) *** separating outer hair cells from SD rats with different day ages,we found that 9 days after birth was a suitable time for the separation of the *** this time,the number of OHCs isolated from rats was large,and the cell morphology was typical of cylindrical *** isolated using this method are histologically suitable and quantitatively adequate for molecular biological and electrophysiological analyses.

关键词： Outer hair cell Isolation technique Morphology sprague-dawley rat

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Effect of ethanolic extract of Pericampylus glaucus (Lam) Merr on biochemical parameters in sprague-dawley rats with high fats diets

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Journal of Coastal Life Medicine 2017年第5期5卷 219-223页

作者： Kifayatullah Muhammad Mustapha Mohd Shahimi Aravinth Vijay Jesuraj Sengupta Pinaki Khan Muhammad Shahid Kaleemullah Faculty of Pharmacy Lincoln University CollegeMalaysia Department of Pharmaceutical Technology Islamic International UniversityMalaysia Faculty of Business and Management Sciences Limkokwing UniversityMalaysia Faculty of Civil and Environmental Engineering UTHM Batu PahatMalaysia

Objective: To evaluate the effect of ethanolic extract of Pericampylus glaucus (Lam) Merr (P. glaucus) on biochemical parameters in high fats diets treated rats. Methods: The effect of P. glaucus extract on biochemical parameters was studied in male sprague dawley rats. The high-fat diets along with standard normal laboratory rat's diets were given for a period of 28 days along with ethanolic extract of P. glaucus and standard drug. The standard group was treated with simvastatin at dose of 80 mg/kg and the tested groups were treated with ethanol extract of P. glaucus at 400, 600 and 800 mg/kg daily for 28 days of the experiment. The weight of animals in each group was measured weekly and the effect of extract and standard on serum lipids profile was evaluated at the end of the study. Results: The results showed that the ethanolic extract of P. glaucus at different doses of 400, 600 and 800 mg/kg and standard drug induced a significant reduction in the body weight (P< 0.001), total cholesterol, triglycerides (TG), low density lipoproteins (LDL) and uric acid levels and increase (P < 0.001) in high density lipoproteins (HDL) as compared to untreated hyperlipidemic group. Conclusions: The present work indicates that the ethanolic extract significantly suppressed the biochemical parameters in high fats diet treated animals, suggesting the antihyperlipidemic potential of P. glaucus.

关键词： Ethanolic extract Pericampylus glaucus (Lam) Merr Biochemical parameters Male sprague-dawley rats

sprague-dawley系大鼠皮下的引发性肉瘤模型

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上海实验动物科学 1985年第1期 13-14页

作者：漆畹生叶静文姚明孙淑屏上海市肿瘤研究所上海市肿瘤研究所

在检测可疑致癌物的工作中,要研究建立多个部位的多种类型的肿瘤模型,皮下肿瘤是其中之一。这一种模型具有不少优点。为了给可疑致癌物的检测工作作准备,作者曾以上海地区引进的sprague-Da-wley系大鼠为实验对象,摸索在皮下建立引发性... 详细信息

在检测可疑致癌物的工作中,要研究建立多个部位的多种类型的肿瘤模型,皮下肿瘤是其中之一。这一种模型具有不少优点。为了给可疑致癌物的检测工作作准备,作者曾以上海地区引进的sprague-Da-wley系大鼠为实验对象,摸索在皮下建立引发性肿瘤模型的规律性。现将初步结果报告如下。材料和方法动物分组:取三月龄的sprague-Dawleey系大鼠,平均体重200克。随机分别归入实验和对照二组。每组雌雄皆有,五只一笼。雌雄分笼,常规饲养。方法:实验之初,以 0.2％的甲基胆蒽(MCA,C21H16,瑞士Fluka产品)麻油溶液注入大鼠右侧第Ⅴ对乳头深部的皮下。每只给1mg/0.5ml,只给一剂。实验组雌性20只、雄性11只。对照组雌雄各10只于

关键词：瘤模型 sprague-dawley 大鼠肝癌鼠皮常规饲养皮下肿瘤甲基胆蒽可疑致癌物照二鼠乳

sprague-dawley大鼠的繁殖与饲养

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上海实验动物科学 1985年第4期 258-260页

作者：胡开元郝光荣第二军医大学

我校由上海市计划生育研究所经世界卫生组织(WHO)从英国CHARLLES RIVER有限公司引进的的sprague-dawley(SD)大鼠,是国际广泛应用的优良品系之一。该种群是美国在1921年用Vistar种群培植而来,目前有纯种和纯系二种。体形较大,性情温顺,... 详细信息

我校由上海市计划生育研究所经世界卫生组织(WHO)从英国CHARLLES RIVER有限公司引进的的sprague-dawley(SD)大鼠,是国际广泛应用的优良品系之一。该种群是美国在1921年用Vistar种群培植而来,目前有纯种和纯系二种。体形较大,性情温顺,发育优良,是营养试验、计划生育和药品检定

关键词：大鼠 sprague-dawley 动物

sprague-dawley系大鼠的饲养与繁殖

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实验动物与比较医学 1984年第1期 36-37页

作者：富群华潘维萍邢宝媛曹芦生上海实验动物研究中心上海市计划生育科学研究所

sprague-dawley系(以下简记为SD系)大鼠是dawley氏在1925年培育成功的。该品种具有体型大、生长发育快、繁殖性能好、性格温驯等优点,故被广泛应用。在计划生育科学研究中,大量使用的是雌性动物。而SD系大鼠每胎能提供较多的实验用动物... 详细信息

sprague-dawley系(以下简记为SD系)大鼠是dawley氏在1925年培育成功的。该品种具有体型大、生长发育快、繁殖性能好、性格温驯等优点,故被广泛应用。在计划生育科学研究中,大量使用的是雌性动物。而SD系大鼠每胎能提供较多的实验用动物,所得的结果也可与国外相比较。本所于1982年4月和

关键词：大鼠 sprague-dawley 产仔数

sprague-dawley品系大鼠实验性心律失常模型

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上海实验动物科学 1988年第2期 74-78页

作者：陶荫祥金跃南京军医学校药理教研室

复制动物心律失常模型的方法很多,其中以药物诱发的方法较为常用。氯仿—肾上腺素诱发家兔心律失常早已被广泛应用,但此法对氯仿麻醉的深度不易掌握,因而影响模型的稳定性和实验结果。笔者用sprague—dawley(SD)品系大鼠为实验对象,摸... 详细信息

复制动物心律失常模型的方法很多,其中以药物诱发的方法较为常用。氯仿—肾上腺素诱发家兔心律失常早已被广泛应用,但此法对氯仿麻醉的深度不易掌握,因而影响模型的稳定性和实验结果。笔者用sprague—dawley(SD)品系大鼠为实验对象,摸索用肾上腺素(AD)诱发心律失常模型的规律性。现将初步结果报告如下。材料与方法一、动物和药品 SD大鼠由南京药物研究所提供,体重150～250克,周龄6～8周,雌雄兼用。盐酸肾上腺素注射液(AD)1mg/ml,北京制药厂产,批号840418。二、模型的建立麻醉用乌拉坦(20％溶液,新鲜配制)按1.2g/kg腹腔注射。手术将麻醉大鼠仰卧保定,切开腹股沟处皮肤,

关键词：心律失常 AD sprague-dawley 室性早搏

sprague-dawley系大鼠内脏器官的重量测定

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实验动物与比较医学 1984年第2期 103-104页

作者：何桂林曹芦生富群华上海实验动物研究中心上海市计划生育科学研究所

实验动物内脏器官的重量、色泽、形态等是衡量实验动物是否健康的标准之一,也是一组基本的生理学数据。本文报道 SD 系大鼠内脏器官重量测定的结果。

关键词：大鼠 sprague-dawley 内脏器官