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Oxidative Damage to spodoptera litura cell Induced by α-Terthienyl

Agricultural Sciences in China 2007年第10期6卷 1217-1223页

作者： WANG Yu-jian HU Lin ZHANG Zhi-xiang XU Han-hong LIAO Mei-de LIAO Shao-yu Key Laboratory of Pesticide and Chemical Biology Ministry of Education/South China Agricultural University Guangzhou 510642 P.R. China Applied Chemistry Institute East China Jiaotong University Nanchang 330013 P.R.China

In this study, the oxidative damage of α-terthienyl （α-T） to the spodoptera litura （SL） cell and its mechanism were investigated. MTT was used to compare the toxicity of α-T and rotenone to the SL cell. The output of malondialdehyde and relative content of glutathione were determined with 2-thiobarbituric acid （TBA） and 5, 5＇-dithio-bis （2-nitrobenzoic acid）（DTNB）, respectively. Transmission electron microscope （TEM） was employed to observe the influence of α-T on the membrane and organelle of the SL cell. The result showed that the IC50 value of α-T to the SL cell was 0.21 μg mL^-1, whereas the corresponding dose of rotenone was 12.25 μg mL^-1. The output of MDA had the same changing tendency with the concentration of α-T, whereas the content of GSH had the negative correlation with it. According to TEM, the cell membrane and karyotheca swelled and couldn＇t retain integrity, the intracellular substances leaked out, unidentified granules appeared in the SL cell. The mitochondria expanded, and the membrane and subcellular organelle were damaged severely. In this study, it was found that after oxidative damage induced by α-T, the output of MDA increased notably, whereas the relative content of GSH decreased. This indicated that the antioxidant ability of cell weakened. The result of TEM implied that the SL cell suffered from oxidative damage under the appointed dose.

关键词： α-Terthienyl spodoptera litura cell oxidative damage malondialdehyde glutathione

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The synthesis and photoactivated cytotoxicity of novel 5-phenyl-3-(2,2':5',2"-terthien-5-yl)-4,5-dihydro-1H-pyrazolines

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Chinese Chemical Letters 2014年第2期25卷 333-336页

作者： Zhi-Gang Luo Zheng-Yong Liu Zhuo-Hong Yang Institute of Biomaterial College of SciencesSouth China Agricultural University

A series of novel 5-phenyl-3-（2,2＇：5＇,2″-terthien-5-yl）-4,5-dihydro-lH-pyrazolines were synthesized in this report. Their photoactivated cytotoxicities on the 5podoptera litura （SL） cell line were evaluated using the MTT method. It was noticed that the inhibitory activities of all the conjugates was enhanced when irradiated with UV-A light. Compounds 4, 6 and 8 were found to be most effective with inhibition rates of 88.1%, 88.0%, and 90,5%, respectively, For compound B, the inhibition rate value was only slightly enhanced under the irradiation treatment （78.3%） compared to the dark treatment （74.8%）. The relationship analysis between structure and activity showed that the middle thiophene ring played an important role on the inhibitory activities. It was shown that these compounds could be the potential candidates for new photoactivated pesticides.

关键词： Terthienyl Pyrazolines Hotoactivated cytotoxicity spodoptera litura cell

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