The synthesis and photoactivated cytotoxicity of novel 5-phenyl-3-(2,2':5',2"-terthien-5-yl)-4,5-dihydro-1H-pyrazolines

作     者：Zhi-Gang Luo Zheng-Yong Liu Zhuo-Hong Yang 

作者机构：Institute of BiomaterialCollege of SciencesSouth China Agricultural University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2014年第25卷第2期

页      面：333-336页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学] 

基　　金：partial financial support by Guangdong Natural Science Foundation(No.7006672) South China Agricultural University Foundation(Nos.2009B010100001, 2009C020604002) 

主　　题：Terthienyl Pyrazolines Hotoactivated cytotoxicity Spodoptera litura cell 

摘      要：A series of novel 5-phenyl-3-（2,2＇：5＇,2″-terthien-5-yl）-4,5-dihydro-lH-pyrazolines were synthesized in this report. Their photoactivated cytotoxicities on the 5podoptera litura （SL） cell line were evaluated using the MTT method. It was noticed that the inhibitory activities of all the conjugates was enhanced when irradiated with UV-A light. Compounds 4, 6 and 8 were found to be most effective with inhibition rates of 88.1%, 88.0%, and 90,5%, respectively, For compound B, the inhibition rate value was only slightly enhanced under the irradiation treatment （78.3%） compared to the dark treatment （74.8%）. The relationship analysis between structure and activity showed that the middle thiophene ring played an important role on the inhibitory activities. It was shown that these compounds could be the potential candidates for new photoactivated pesticides.