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Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease

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World Journal of Gastroenterology 2017年第8期23卷 1345-1352页

作者： Kawa Amin Aram H Rasool Ali Hattem Taha AM Al-Karboly Taher E Taher Jonas Bystrom Department of Medical Science Respiratory Medicine and AllergologyClinical Chemistry and Asthma Research CentreUppsala University and University Hospital Department of Microbiology/Immunology School of MedicineUniversity of Sulaimani Laboratory Department General Hospital of Derbandixan Department of Community Health Sulaimani Polytechnic University Department of Medicine School of MedicineFaculty of Medical SciencesUniversity of Sulaimani Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and the LondonQueen MaryUniversity of London

To determine how the auto-antibodies (Abs) profiles overlap in chronic hepatitis C infection (CHC) and autoimmune hepatitis (AIH) and correlate to liver *** of antinuclear Ab, smooth muscle antibody (SMA) and liver/kidney microsomal-1 (LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune *** found that AIH patients had more severe liver disease as determined by elevation of total IgG, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies (auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total IgG. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1+ Ab CHC cases showed best overlap with ***-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other.

关键词： Autoantibody Inflammatory diseases Immune system Hepatitis C virus smooth muscle antibody Liver/kidney microsomal-1 autoantibody Anti-nuclear antibody

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