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Effect of Sini San Freeze-dried powder on sleep-waking cycle in insomnia rats

Journal of Traditional Chinese Medicine 2014年第5期34卷 572-575页

作者： Xingke Yan Zeguo Zhang Fuju Xu Yuefeng Li Tiantian Zhu Chongbing Ma Anguo Liu Department of Pharmacy Department of AcupunctureGansu University of Traditional Chinese Medicine Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicines of Gansu Province Department of Acupuncture Gansu University of Traditional Chinese Medicine

OBJECTIVE: To investigate the effects of the Sini San at different doses on each sleeping state[slow-wave sleep 1(SWS1), slow-wave sleep 2(SWS2), rapid-eye-movement(REM), wakefulness(W)] in insomnia rats and to identify its mode of ac-tion for improving ***: The insomnia rats were randomly divided into a high-, medium- or low-dose group of Sini San(equal to crude drug 8.8, 4.4, or 2.2 g/kg, respectively) for seven consecutive ***: Compared with pre-administration,SWS2 was significantly increased after administration of the low dose. Compared with pre-administration, W was significantly decreased and SWS1,SWS2, and the total sleeping time(TST) were markedly increased after administration of the medium dose. Compared with pre-administration, W was significantly decreased and SWS1, SWS2, rapid-eye-movement sleep, and TST were significantly longer after administration of the high dose. The effects of Sini San on sleep-wake cycle are ***: The results suggest that Sini San extends SWS1 and SWS2, which increases the total sleeping time.

关键词： sleep initiation and maintenance disor-ders Electroencephalography sleep stages Medi-cine, Chinese Traditional Sini San

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