Effect of Sini San Freeze-dried powder on sleep-waking cycle in insomnia rats

作     者：Xingke Yan Zeguo Zhang Fuju Xu Yuefeng Li Tiantian Zhu Chongbing Ma Anguo Liu 

作者机构：Department of PharmacyDepartment of AcupunctureGansu University of Traditional Chinese Medicine Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicines of Gansu Province Department of AcupunctureGansu University of Traditional Chinese Medicine 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2014年第34卷第5期

页      面：572-575页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Hippocampus Neural Coding Mechanism Research on Sini San Intervention Sleep Disorders of PTSD in Myospalax cansus from the National Natural Science Foundation(No.81460611) Study on Sini San for regulation of expression of proteins of drosophila brain of sleep deprivation of Gansu Province Natural Science Foundation(No.145RJZA076) Fundamental Research Funds for the Gansu Provincial Department of Finance Universities(No.2013-2) Mechanisms of hippocampal neurons based on Jiawei Sini San intervention coding mode PTSD sleep disorders Ministry of Education,Sini San for intervention of sleep deprivation in drosophila Based nano-2D-LC/MS technology of Science and Technology Key Project(No.212186) Proteomics and effective substance basic of Sini San for improving sleep of Gansu Province Natural Science Foundation(No.1010RJZA212) 

主　　题：Sleep initiation and maintenance disor-ders Electroencephalography Sleep stages Medi-cine, Chinese Traditional Sini San 

摘      要：OBJECTIVE: To investigate the effects of the Sini San at different doses on each sleeping state[slow-wave sleep 1(SWS1), slow-wave sleep 2(SWS2), rapid-eye-movement(REM), wakefulness(W)] in insomnia rats and to identify its mode of ac-tion for improving ***: The insomnia rats were randomly divided into a high-, medium- or low-dose group of Sini San(equal to crude drug 8.8, 4.4, or 2.2 g/kg, respectively) for seven consecutive ***: Compared with pre-administration,SWS2 was significantly increased after administration of the low dose. Compared with pre-administration, W was significantly decreased and SWS1,SWS2, and the total sleeping time(TST) were markedly increased after administration of the medium dose. Compared with pre-administration, W was significantly decreased and SWS1, SWS2, rapid-eye-movement sleep, and TST were significantly longer after administration of the high dose. The effects of Sini San on sleep-wake cycle are ***: The results suggest that Sini San extends SWS1 and SWS2, which increases the total sleeping time.