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3D Bioprinted skin substitutes for Accelerated Wound Healing and Reduced Scar

Journal of Bionic Engineering 2021年第4期18卷 900-914页

作者： Qin Lian Tian Jiao Tingze Zhao Huichao Wang Siming Yang Dichen Li State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an710049China Chinese PLA General Hospital Beijing100853China

The shortage of skin for grafting continues to be a major problem in the treatment of serious skin injuries.3D bioprinting provides a new way to solve this ***,current 3D printed skin is less effective in treatment of large wounds because of severe shrinkage and *** this study,bionically designed bilayer skin was fabricated using an extrusion-based bioprinter and a gelatin/sodium alginate/gelatin methacrylate hydrogel with excellent physical and biological ***-thickness skin wounds were created in the back of nude mice and treated with bioprinted skin or *** skin accelerated wound healing,reduced wound contraction and scarring,and facilitated wound skin epithelialization compared with the bioprinted hydrogel or untreated *** skin from the wound was collected 28 days after grafting for histology and immunofluorescence *** thickness of the dermis and epidermis of the bioprinted skin was similar to that of nude *** formation in the dermis and dense keratinocytes in the epidermis of the bioprinted skin were *** study provides a potential treatment strategy for reducing skin contraction and scar in large skin wounds.

关键词： 3D bioprinting bionic design skin substitutes wound healing reducing scar

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Development and use of biomaterials as wound healing therapies

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Burns & Trauma 2019年第1期7卷 8-16页

作者： Rachael Zoe Murray Zoe Elizabeth West Allison June Cowin Brooke Louise Farrugia The Institute for Health and Biomedical Innovation School of Biomedical SciencesFaculty of HealthQueensland University of TechnologyBrisbaneQLD 4059Australia Future Industries Institute University of South AustraliaAdelaideSA 5095Australia.3Graduate School of Biomedical EngineeringUniversity of New South WalesSydneyNSW 2052Australia Graduate School of Biomedical Engineering University of New South WalesSydneyNSW 2052Australia Full list of author information is available at the end of the article

There is a vast number of treatments on the market for the management of wounds and burns,representing a multi-billion dollar industry *** include conventional wound dressings,dressings that incorporate growth factors to stimulate and facilitate the wound healing process,and skin substitutes that incorporate patientderived *** article will review the more established,and the recent advances in the use of biomaterials for wound healing therapies,and their future direction.

关键词： Wound healing Wounds Burns Biomaterials skin substitutes

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