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Diabetes and skin cancers: Risk factors, molecular mechanisms and impact on prognosis

World Journal of Clinical Cases 2022年第31期10卷 11214-11225页

作者： Elena-Codruta Dobrică Madalina Laura Banciu Vincent Kipkorir Mohammad Amin Khazeei Tabari Madeleine Jemima Cox L V Simhachalam Kutikuppala Mihnea-Alexandru Găman Doctoral School University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Department of Dermatology "Elias"University Emergency HospitalBucharest 011461Romania Department of Human Anatomy University of NairobiCollege of Health SciencesNairobi 00100Kenya USERN Office Mazandaran University of Medical SciencesSari 48175-866Iran University of New South Wales University of New South WalesSydney 2052Australia Dr NTR University of Health Sciences VijayawadaAndhra Pradesh 520008India Faculty of Medicine "Carol Davila"University of Medicine and PharmacyBucharest 050474Romania

Diabetes and skin cancers have emerged as threats to public health ***,their association has been less intensively *** this narrative review,we explore the common risk factors,molecular mechanisms,and prognosis of the association between cutaneous malignancies and ***,oxidative stress,low-grade chronic inflammation,genetic,lifestyle,and environmental factors partially explain the crosstalk between skin cancers and this metabolic *** addition,diabetes and its related complications may interfere with the appropriate management of cutaneous *** medication seems to exert an antineoplastic effect,however,future large,observation studies with a prospective design are needed to clarify its impact on the risk of malignancy in *** for diabetes in skin cancers,as well as close follow-up for the development of cutaneous malignancies in subjects suffering from diabetes,is warranted.

关键词： Diabetes skin cancers Squamous cell carcinoma Melanoma Basocellular carcicoma

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The Relationship Between Ultraviolet B and DNA Methylation in skin cancers

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International Journal of Dermatology and Venereology 2023年第3期6卷 157-162页

作者： Yi-Lin Wu Yue-Yue Zhang Yong He Qun Lyu Li-Ming Li Ming-Jun Jiang Jiangsu Key Laboratory of Molecular Biology for skin Diseases and STIs Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical SciencesPeking Union Medical CollegeNanjingJiangsu 210042China Outpatient Department Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210042China Department of Dermatologic Surgery Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical SciencesPeking Union Medical CollegeNanjingJiangsu 210042China

Ultraviolet B is regarded as an important factor in many skin diseases,especially skin *** more evidence is showing that changes in DNA methylation occur in patients with skin *** in DNA methylation have also been observed in ultraviolet B-irradiated cells and mouse *** methylation modifier enzymes are simultaneously *** herein review the evidence to date showing that Ultraviolet B affects changes in DNA methylation modifier enzymes in skin ***,the mechanism of how ultraviolet B regulates the changes in DNA methylation modifier enzymes remains to be further *** the mechanism by which ultraviolet B modulates DNA methylation modifier enzymes can help to identify potential therapeutic markers or targets and develop novel strategies for preventing or treating ultraviolet B-induced skin damage.

关键词： DNA methylation DNA methyltransferases skin cancers ten-eleven translocations ultraviolet B

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Survey on the Knowledge, Attitudes, Primary Prevention Practices and Screening of skin cancers in Albinos in Burkina Faso

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Journal of Cancer Therapy 2016年第11期7卷 812-823页

作者： Smaila Ouédraogo Nayi Zongo Nina Korsaga-Somé Seraphine Marie Suzanne Kaboré Edgar Ouangré Maurice Zida A. S. Ouédraogo Aboubacar Hierrum Bambara Augustin Touzoula Bambara Si Simon Traoré Pascal Niamba Adama Traoré Ahmadou Dem Public Health Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso General and Digestive Surgery Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Dermatology and Venerology Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Pathological Anatomy and Forensic Unit Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Oncology Institute Joliot Curie of Dakar Dakar Senegal

The objective is to study the knowledge that albinos have on skin cancers, and their attitudes in terms of primary prevention and the screening practices for skin cancers in Burkina Faso. Methods: This is a cross-sectional and descriptive KAP study conducted from May 18th to July 7th 2015. It involved albinos aged at least 12 years. Their general knowledge, prevention attitudes and screening practices were considered. Results: All the responding albinos had already heard about skin cancers. Their main source of information was health workers (65.6%). They were showing at least two risk factors (99.2%) but only 68.3% affirmed having already undergone screening for skin cancer. Ignorance of the existence of screening was the main obstacle to it (16/26). The prevention means used was sun avoidance, the use of cream and protection clothing respectively in 84%, 41.5% and 51.2%. The skin lesions found were hyperpigmented macules (77.8%) then actinic keratosis (40.7%) and finally cheilitis (35.8%). We detected 4 cases of skin cancers confirmed by biopsy. Conclusion: Risk factors are frequent. Participation to screening is still insignificant. A lot is still to be done to extend the protection means. A good awareness-raising campaign and the accessibility to protection means remain for all, the best defense in the fight against skin cancers in albinos.

关键词： Albinos Screening Prevention skin cancers

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