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Lymph node metastasis from non-melanoma skin cancer

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 379-392页

作者： Robbie S.R.Woods Jack F.C.Woods Conall W.R.Fitzgerald Ehab Alameer Joseph Lopez Bhuvanesh Singh Jatin P.Shah Department of Head&Neck Surgery Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Plastic&Reconstructive Surgery Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA

The management of non-melanoma skin cancers metastatic to the neck is challenging due to variability in biological behavior and patterns of regional lymphatic *** non-melanoma skin cancers to the parotid and neck often behave aggressively,with a high incidence of local recurrence after treatment and reduced five-year survival *** of lymphatic spread are different from those seen in mucosal squamous cell carcinoma,with higher prevalence of disease in the parotid and superficial *** factors require that treatment is individualized to achieve optimal ***,the management of non-melanoma skin cancers metastatic to lymph nodes has involved surgical excision followed by adjuvant radiation ***,novel systemic therapies are showing promising results and their role in the management of these cancers is evolving.

关键词： Neck non-melanoma cutaneous malignancy skin neoplasms lymph nodes lymphatic metastasis

Associated Factors of Anxiety Symptoms in Patients with Keratinocyte Carcinoma:A Cross-Sectional Study

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Psycho-Oncologie 2024年第3期18卷 213-221页

作者： Qian Liu Hui Zhang Juan Gao Meiping Sha Lijun Shen Xianfeng Cheng Hao Chen No.4 Ward Hospital for Skin Diseases and Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing210042China Department of One-Stop Service Center Hospital for Skin Diseases and Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing210042China Department of Clinical Laboratory Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing210042China Pathology Department Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing210042China

Background:Keratinocyte carcinoma(KC)is a common malignancy characterized by a high recurrence rate and considerable psychological *** incidence of KC is increasing in China,raising concerns about its psychological consequences and adverse effects on quality of *** and clinical factors are thought to inﬂuence mental health outcomes in these ***,data on the prevalence of anxiety in Chinese patients with KC and the factors associated with this anxiety are notably ***,a comprehensive investigation into the anxiety of patients with KC is ***:This study aimed to investigate the prevalence of anxiety in patients with KC,a disease that can signiﬁcantly affect a patient’s appearance and overall quality of *** the level of anxiety in this population is critical to developing targeted interventions,improving treatment outcomes,supporting mental health,and improving patient care ***:This cross-sectional study was conducted at China’s largest dermatology hospital from November 2017 to September 2022.A consecutive sampling method was used to recruit *** status was surveyed by the Self-rating Anxiety Scale(SAS).Explanatory variables were surveyed by demographic data ***-parametric test and Chi-square test analyses were used to compare the differences between *** linear regression analysis was performed to identify factors associated with ***:A total of 192 patients with KC were *** median score of SAS was 35(IQR 16.25).The prevalence of anxiety in patients with KC was 20.8%.Females(p=0.008),under 60 years old(p=0.011),living in rural(p=0.010)or urban areas(p=0.029),having fewer than three children(p=0.016),with a history of skin diseases(p<0.001),with a history of long-term oral medication(p=0.001),and experiencing pain or itching(p=0.001)had SAS scores that were signiﬁcantly higher than their ***:T

关键词： Anxiety skin neoplasms risk factors

Evaluation of chemopreventive potentials of ethanolic extract of Ruta graveolens against A375 skin melanoma cells in vitro and induced skin cancer in mice in vivo

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Journal of Integrative Medicine 2015年第1期13卷 34-44页

作者： Samrat Ghosh Sourav Sikdar Avinaba Mukherjee Anisur Rahman Khuda-Bukhsh Cytogenetics and Molecular Biology Laboratory Department of Zoology University of Kalyani

OBJECTIVE： Chemopreventive approach with natural products, particularly plants and plant-derived ones, is receiving increasing attention for their effective role against cancer without any palpable side effects. In this study, efficacy of ethanolic extract of Ruta graveolens （RG） on skin melanoma cells （A375） in vitro and on 7,12-dimethylbenz（a）anthracene （DMBA）-induced skin cancer in vivo has been tested in Swiss albino mice. METHODS： Studies on cell viability, apoptosis and autophagy induction were conducted in vitro. To check apoptosis, assays like alteration in mitochondrial membrane potential, annexin V-fluorescein isothiocyanate/propidium iodide assay and immunoblot were performed. Fluorescence microscopic and immunoblot assays were performed to confirm autophagy induction. The effects of RG were determined by evaluating body weight, tumor incidence, tumor volume and tumor burden in mice. Enzymatic and non-enzymatic antioxidant status was assessed. The role of some relevant signaling proteins was also analyzed. RESULTS： RG caused death ofA375 cells through induction of caspase 3-mediated apoptosis and Beclin-l-associated autophagy. Moreover, RG administration （75 mg/kg body weight） which showed no acute or chronic toxicity, showed significant reduction in the skin tumor burden of DMBA-painted mice. RG also demonstrated potent anti-lipid peroxidative and antioxidant functions during the course of skin cancer induction by DMBA. CONCLUSION： Chemopreventive potential of RG was demonstrated from overall results of this study indicating its possible use in therapeutic formulation of an effective drug to treat skin cancer.

关键词： Ruta graveolens plant extracts chemoprevention skin neoplasms apoptosis autophagy

Pathology of Vascular skin Lesions (Current Clinical Pathology) 1

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Homeopathic mother tincture of Phytolacca decandra induces apoptosis in skin melanoma cells by activating caspase-mediated signaling via reactive oxygen species elevation

丛书名： Current Clinical Pathology

2003年

作者： Omar P. Sangueza Luis Requena

来源：畅想之星图书光盘版（南... 评论

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Journal of Integrative Medicine 2013年第2期11卷 116-124页

作者： Samrat Ghosh Kausik Bishayee Avijit Paul Avinaba Mukherjee Sourav Sikdar Debrup Chakraborty Naoual Boujedaini Anisur Rahman Khuda-Bukhsh Cytogenetics and Molecular Biology Laboratory Department of Zoology University of Kalyani Boiron Laboratories

OBJECTIVE： Preventive measures against skin melanoma like chemotherapy are useful but suffer from chronic side effects and drug resistance. Ethanolic extract of Phytolacca decandra （PD）, used in homeopathy for the treatment of various ailments like chronic rheumatism, regular conjunctivitis, psoriasis, and in some skin diseases was tested for its possible anticancer potential. METHODS： Cytotoxicity of the drug was tested by conducting 3-（4,5-dimethylthiazol-2-yl）-2,5- diphenyltetrazolium bromide assay on both normal （peripheral blood mononuclear cells） and A375 cells. Fluorescence microscopic study of 4＇,6-diamidino-2-phenylindole dihydrochloride-stained cells was conducted for DNA fragmentation assay, and changes in cellular morphology, if any, were also recorded. Lactate dehydrogenase activity assay was done to evaluate the percentages of apoptosis and necrosis. Reactive oxygen species （ROS） accumulation, if any, and expression study of apoptotic genes also were evaluated to pin-point the actual events of apoptosis. RESULTS： Results showed that PD administration caused a remarkable reduction in proliferation of A375 cells, without showing much cytotoxicity on peripheral blood mononuclear cells. Generation of ROS and DNA damage, which made the cancer cells prone to apoptosis, were found to be enhanced in PD-treated cells. These results were duly supported by the analytical data on expression of different cellular and nuclear proteins, as for example, by down- regulation of Akt and Bcl-2, up-regulation of p53, Bax and caspase 3, and an increase in number of cell deaths by apoptosis in A375 cells. CONCLUSION： Overall results demonstrate anticancer potentials of PD on A375 cells through activation of caspase-mediated signaling and ROS generation.

关键词： Phytolacca decandra skin neoplasms reactive oxygen species apoptosis gene expression

Treatment of Neurofibromatosis with Chinese Herbal Drugs

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Journal of Traditional Chinese Medicine 2000年第4期20卷 262-264页

作者：周小平王会平袁庆东周永生 Suzhou Municipal Maternity and Child Health Hospital Suzhou 215004Jiangsu Province The Affiliated Hospital of Liaoning College of Traditional Chinese Medicine Shenyang 110032Liaoning Province

Neurofibromatosis is a dominantly inheriteddefect of the ectoderm,characterized by cafe au laitspots since the childhood and multiple tumorsderived from elements of peripheral and ***-like tumors of various sizes can oftenbe felt under the skin and serve as a valuablecharacteristic in making ***,theycan also affect brain,vegetative nerve system or othertissues and lead to bony abnormalities,mentaldisturbances and sometimes,endocrine abnormalities,

关键词： Adult Child Drugs, Chinese Herbal Female Humans Male Neurofibromatosis 1 skin neoplasms

Primary cutaneous CD30-positive anaplastic large cell lymphoma analysis

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Chinese Medical Journal 2002年第12期115卷 1802-1805,147页

作者：石群立周晓军燕晓雯徐新宇印洪林张彤社本擀博钱斌南京军区南京总医院病理科南京大学临床医学院南京210002 江苏省肿瘤医院病理科南京210002 日本名古屋藤田保健卫生大学病理系

OBJECTIVE: To examine 10 cases with primary cutaneous CD30-positive anaplastic large cell lymphoma (ALCL), analyze their clinical manifestations and pathological and immunohistochemical features, and improve early diagnosis of this disease. METHODS: We studied the morphological characteristics of primary cutaneous CD30-positive ALCL using histopathological methods. Leukocyte common antigen (LCA), CD20, CD30, CD45RO, CD68, epithelial membrane antigen (EMA), cytokeratin (CK) and HMB45 antibodies were used to determine the expression of their respective antigens from routine paraffin samples of the patients. RESULTS: Ten patients (7 men and 3 women, aged 31 to 84 years) complained of subcutaneous masses or papular eruptions over their lower trunks and extremities. Histopathologically, the lesions were composed of numerous large round or oval pleomorphic cells. The cytoplasm was usually abundant, amphophilic or basophilic, and finely vacuolated. Nuclei were commonly eccentrically localized and lobated or horseshoed in shape, and multinucleated giant cells and Reed-Sternberg-like cells were seen. Nucleoli were generally multiple and large. Of the 10 patients, tumor cells displayed positive antigen expression of CD30 in all cases, positive CD45RO in 6 cases, positive CD20 in only 1 case, but negative CD45RO and CD20 expressions in 3 cases. Two patients died at 7 weeks and 3.4 years of follow-up, respectively. CONCLUSION: Our study highlights the importance of histopathologic features and positive CD30 staining for differentiation of this disease from other malignant skin tumors.

关键词： Adult Aged Aged, 80 and over Antigens, CD30 Antigens, CD45 Diagnosis, Differential Female Humans Immunohistochemistry Lymphoma, Large-Cell, Ki-1 Male Middle Aged skin neoplasms

Effect of Q-switched alexandrite laser irradiation on dermal melanocytes of nevus of Ota

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Chinese Medical Journal 2000年第1期113卷 49-52页

作者：卢忠陈军庞王侠生方丽华焦圣黄雯 China 200040

OBJECTIVE: To investigate the effect of Q-switched alexandrite laser irradiation on dermal melanocytes of nevus of Ota. METHODS: Multiple biopsies were carried out on 4 patients with nevus of Ota before and after laser irradiation. Altogether 11 samples were examined under light microscope and 14 under transmission electron microscope. RESULTS: Immediately after laser irradiation, the dermal melanocytes were destroyed, the melanosomes were degenerated with central vesicle formation within most of them, and intradermal round vacuoles appeared. The epidermis remained intact. Three months to 1 year after irradiation, the degenerated melanosomes and cell debris were scavenged mainly by macrophages. Dermal melanocytes gradually decreased. No fibrosis was found. CONCLUSION: Q-switched alexandrite laser can selectively destroy dermal melanocytes of nevus of Ota and treat the disease safely.

关键词： Adolescent Adult Female Humans Lasers Melanocytes Microscopy, Electron Nevus of Ota Pigmentation Disorders skin neoplasms

Needle track seeding:A real hazard after percutaneous radiofrequency ablation for colorectal liver metastasis

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World Journal of Gastroenterology 2009年第13期15卷 1653-1655页

作者： Shirley Yuk-Wah Liu Kit-Fai Lee Paul Bo-San Lai Division of Hepato-biliary and Pancreatic Surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong Kong

Neoplastic needle track seeding following percutaneous radiofrequency ablation(RFA)of secondary liver tumors is exceedingly *** on cutaneous tumor seeding after percutaneous RFA for colorectal liver metastasis are even rarer in the *** we report a case of a 46-year-old female who developed an ulcerating skin lesion along the needle track of a previous percutaneous RFA site around 6 mo after the *** previous RFA was performed by the LeVeen needle for a secondary liver tumor from a primary rectal *** diagnosis of secondary skin metastasis was confirmed by fine needle aspiration *** lesion was successfully treated with wide local *** believe that tumor seeding after percutaneous RFA in our patient was possibly related to its unfavorable subcapsular location and the use of an expansion-type ***,prophylactic ablation of the needle track should be performed whenever ***,alternative routes of tumor ablation such as laparoscopic or open RFA should be considered.

关键词： Radiofrequency catheter ablation Needles Neoplasm seeding Liver neoplasms skin neoplasms Neoplasm metastasis