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In vitro and in vivo investigation of bacterial cellulose dressing containing uniform silver sulfadiazine nanoparticles for burn wound healing

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Progress in Natural Science:Materials International 2015年第3期25卷 197-203页

作者： Xiaoxiao Wen Yudong Zheng Jian Wu Lina Yue Cai Wang Jiabin Luan Zhigu Wu Kaisheng Wang School of Materials Science and Engineering University of Science and Technology Beijing Suzhou Institute of Nano-Tech and Nano-biobics Chinese Academy of Sciences Hospital Affiliated to Chinese PLA General Hospital

silver sulfadiazine(SSD) particles in homogeneous dispersion state were prepared by an ultrasonic method and then nano- and microparticles were separated using centrifugation. SSD particles with narrow size distribution were impregnated with bacterial cellulose(BC) to produce BC–SSD composite membrane used as burn wound dressing. A scanning electron microscope(SEM) was used to examine the surface morphology of BC–SSD membranes. The incorporation of SSD in BC–SSD was confirmed by X-ray diffraction(XRD). Antimicrobial tests in vitro indicated that BC–SSD showed excellent antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effects of BC–SSD on burn wound healing were assessed by rat models. The comparative study confirmed that the wound treated with BC–SSD showed high healing rate. The bacteria count in BC–SSD group was far less than control group. Histological analysis showed that epithelialization progressed better in wound treated with BC–SSD. These values demonstrated that the BC–SSD composite membrane could be a promising wound dressing for burn.

关键词： Bacterial cellulose silver sulfadiazine Antibacterial activity Burn wound healing

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Propolis modulates vitronectin,laminin,and heparan sulfate/heparin expression during experimental burn healing

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 932-941页

作者： Pawe OLCZYK Katarzyna KOMOSINSKA-VASSEV Katarzyna WINSZ-SZCZOTKA Ewa M.KOZMA Grzegorz WISOWSKI Jerzy STOJKO Katarzyna KLIMEK Krystyna OLCZYK Department of Clinical Chemistry and Laboratory Diagnostics Medical University of Silesia41-200 SosnowiecPoland Center of Experimental Medicine Medical University of Silesia40-752 KatowicePoland Department of Statistics Medical University of Silesia41-200 SosnowiecPoland

Objective:This study was aimed at assessing the dynamics of vitronectin (VN), laminin (LN), and heparan sulfate/heparin (HS/HP) content changes during experimental burn healing. Methods:VN, LN, and HS/HP were isolated and purified from normal and injured skin of domestic pigs, on the 3rd, 5th, 10th, 15th, and 21st days following thermal damage. The wounds were treated with apitherapeutic agent (propolis), silver sulfadiazine (SSD), physiological salt solution, and propolis vehicle. VN and LN were quantified using an immunoenzymatic assay and HS/HP was estimated by densitometric analysis. Results:Propolis treatment stimulated significant increases in VN, LN, and HS/HP contents during the initial phase of study, followed by a reduction in the estimated extracellular matrix molecules. Similar patterns, although less extreme, were observed after treatment with SSD. Conclusions:The beneficial effects of propolis on experimental wounds make it a potential apitherapeutic agent in topical burn management.

关键词： Apitherapeutic agent silver sulfadiazine Laminin Vitronectin Heparan sulfate/heparin Wound healing

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