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sickle cell nephropathy:A review of novel biomarkers and their potential roles in early detection of renal involvement

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World Journal of Clinical Pediatrics 2022年第1期11卷 14-26页

作者： Osama Y Safdar Rana M Baghdadi Sereen A Alahmadi Bana E Fakieh Amaal M Algaydi of Pediatric King Abdulaziz UniversityJEDDAH 21414Saudi Arabia College of Medicine King Abdulaziz UniversityJEDDAH 21422Saudi Arabia

Whether the underlying mutations are homozygous,heterozygous,or coinherited with other hemoglobinopathies,sickle cell disease is known to afflict the kidneys,leading to the clinical entity known as sickle cell nephropathy(SCN).Although common,SCN remains diagnostically *** studies performed in the context of renal disorders often fail to detect early stage *** makes the quest for early diagnosis and treatment more challenging,and it increases the burden of chronic kidney disease-related morbidity among *** diagnostic tools have been employed to overcome this *** this study,we discuss various biomarkers of SCN,including those employed in clinical practice and others recently identified in experimental settings,such as markers of vascular injury,endothelial dysfunction,tubulo-glomerular damage,and oxidative *** include kidney injury molecule-1,monocyte chemoattractant protein-1,N-acetyl-B-D-glucosaminidase,ceruloplasmin,orosomucoid,nephrin,and cation channels,among ***,we explore the potential of novel biomarkers for refining diagnostic and therapeutic approaches and describe some obstacles that still need to be *** highlight the importance of a collaborative approach to standardize the use of promising new ***,we outline the limitations of conventional markers of renal damage as extensions of the pathogenic process occurring at the level of the organ and its functional subunits,with a discussion of the expected pattern of clinical and biochemical progression among patients with SCN.

关键词： sickle cell disease sickle cell nephropathy Chronic kidney disease Kidney injury molecule-1 Monocyte chemoattractant protein-1 N-acetyl-B-D-glucosaminidase

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