Sickle cell nephropathy:A review of novel biomarkers and their potential roles in early detection of renal involvement

作     者：Osama Y Safdar Rana M Baghdadi Sereen A Alahmadi Bana E Fakieh Amaal M Algaydi 

作者机构：of PediatricKing Abdulaziz UniversityJEDDAH 21414Saudi Arabia College of MedicineKing Abdulaziz UniversityJEDDAH 21422Saudi Arabia 

出 版 物：《World Journal of Clinical Pediatrics》 (世界临床儿科杂志)

年 卷 期：2022年第11卷第1期

页      面：14-26页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Sickle cell disease Sickle cell nephropathy Chronic kidney disease Kidney injury molecule-1 Monocyte chemoattractant protein-1 N-acetyl-B-D-glucosaminidase 

摘      要：Whether the underlying mutations are homozygous,heterozygous,or coinherited with other hemoglobinopathies,sickle cell disease is known to afflict the kidneys,leading to the clinical entity known as sickle cell nephropathy(SCN).Although common,SCN remains diagnostically *** studies performed in the context of renal disorders often fail to detect early stage *** makes the quest for early diagnosis and treatment more challenging,and it increases the burden of chronic kidney disease-related morbidity among *** diagnostic tools have been employed to overcome this *** this study,we discuss various biomarkers of SCN,including those employed in clinical practice and others recently identified in experimental settings,such as markers of vascular injury,endothelial dysfunction,tubulo-glomerular damage,and oxidative *** include kidney injury molecule-1,monocyte chemoattractant protein-1,N-acetyl-B-D-glucosaminidase,ceruloplasmin,orosomucoid,nephrin,and cation channels,among ***,we explore the potential of novel biomarkers for refining diagnostic and therapeutic approaches and describe some obstacles that still need to be *** highlight the importance of a collaborative approach to standardize the use of promising new ***,we outline the limitations of conventional markers of renal damage as extensions of the pathogenic process occurring at the level of the organ and its functional subunits,with a discussion of the expected pattern of clinical and biochemical progression among patients with SCN.