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Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by shugan decoction

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World Journal of Gastroenterology 2015年第16期21卷 4852-4863页

作者： Hai-Lian Shi Chu-Hsuan Liu Li-Li Ding Yu Zheng Xiao-Yan Fei Lu Lu Xue-Ming Zhou Jian-Ye Yuan Jian-Qun Xie Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese Medicine Institute of Chinese Materia Medica Shanghai Key Laboratory of Complex PrescriptionShanghai University of Traditional Chinese Medicine Experimental Animal Center Shanghai University of Traditional Chinese Medicine

AIM:To determine the molecular mechanisms of shugan decoction(SGD) in the regulation of colonic motility and visceral hyperalgesia(VHL) in irritable bowel syndrome(IBS).METHODS:The chemical compounds contained in SGD were measured by high-performance liquid chromatography.A rat model of IBS was induced by chronic water avoidance stress(WAS).The number of fecal pellets was counted after WAS and the pain pressure threshold was measured by colorectal *** changes in colonic mucosa were detected by hematoxylin-eosin *** contents of tumor necrosis factor(TNF)-αin colonic tissue and calcitonin-gene-related peptide(CGRP)in serum were measured by *** protein expression of serotonin[5-hydroxytryptamide(5-HT)],serotonin transporter(SERT),chromogranin A(Cg A)and CGRP incolon tissue was measured by ***:SGD inhibited colonic motility dysfunction and VHL in rats with *** of transient receptor potential(TRP)vanilloid 1(TRPV1)(Ruthenium Red)and TRP ankyrin-1(TRPA1)(HC-030031)and activator of protease-activated receptor(PAR)4 increased the pain pressure threshold,whereas activators of PAR2and TRPV4 decreased the pain pressure threshold in rats with *** effect of SGD on pain pressure threshold in these rats was abolished by activators of TRPV1(capsaicin),TRPV4(RN1747),TRPA1(Polygodial)and PAR2(AC55541).In addition,CGRP levels in serum and colonic tissue were both increased in these ***-αlevel in colonic tissue was also significantly ***,the levels of 5-HT,SERT and Cg A in colonic tissue were *** these pathological changes in rats with IBS were attenuated by ***:SGD alleviated VHL and attenuated colon motility in IBS,partly by regulating TRPV1,TRPV4,TRPA1,PAR2,5-HT,Cg A and SERT,and reducing CGRP and TNF-αlevel.

关键词： shugan decoction Visceral hyperalgesia Serotonin Transient receptor potential Proteaseactivatedreceptor Serotonin transporter Calcitoningene-related peptide Tumor necrosis factor-α

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A model for anticancer surveillance was pharmacologically developed to evaluate vitality principle in breast cancer rats

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Journal of Traditional Chinese Medicine 2018年第6期38卷 823-833页

作者： Liu Jinyu Zhang Mengyang Zhao Xin Ge Shasha Li Shuang Peng Lin Mu Yuxue Chen Chen Li Xiaoya Zhang Rui Feng Xuanye Deng Bo Jia Liqun Lin Yulin Wang Yueqi Cheng Zhiqiang TaeHoo Yi Cai Dayong Research Center for Pharmcology and Toxicology Institute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193China College of Basic Medicine Beijing University of Chinese MedicineBeijing 100029China Oncology Department of Chinese Medicine China-Japan Friendship HospitalBeijing 100029China College of Life Sciences Kyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea

OBJECTIVE: To evaluate vitality principle in breast cancer rats by pharmacologically developing a model for anticancer ***: The breast cancer in rats was replicated with 7,12-Dimethylbenz[a]anthracene(DMBA, i.g.,100 mg/kg) at d_(001). The anticancer surveillance was defined as the intervals between the primary sensitization and the first challenge stirred with complete Freund's adjuvant(CFA), the various intervals(k = 0.80) were dominated from d_(025)(600.00 h) to d_(095)(2288.82 h). The optimal surveillant status was confirmed with the median effective interval(EI_(50))from tumor volume regressive curve, for developing the pharmacodynamic model. The tumor and tumor infiltrating lymphocyte histopathology was used to confirm the immune surveillance being affected with CFA in breast cancer *** availability of this model was confirmed with shugan Liangxue prescription(SLP), from the vitality principle, and assured further from interleukin-12 ***: The regressive curve was set up between the intervals and tumor volumes, the EI_(50) in SLP-treated rats(1475.00 h, Y_(SLP)= 0.1026 +0.8780/[1 + 10^(27.1425-8.565x)]) was postponed, which was 1.87 multiple of the EI_(50) in CFA rats(791.40 h, y =-0.0525 + 0.9452/[1 + 10^(30.4870-10.52x)], so did prepone the curve between the intervals and the immunological biomarker, serum interleukin-12 levels, the EI_(50) in SLP-treated rats(744.90 h, Y_(SLP)=-0.0145 + 0.7455/[1 + 10^(52.09636-18.13x)]) be 0.78 multiple of the EI_(50) in CFA rats(960.10 h, Y_(CFA)= 0.2460 + 0.7270/[1 + 10^(-67.1546 +22.52x)]), this immunological action being mediated the anticancer prognosis. Tumor histology was confirmed the more tumor infiltrating lymphocytes activated in SLP rats with CFA stirred immunity than rats only received ***: The model for anticancer surveillance was pharmacologically established as the optimal interval(791.40 h) between the primary sensitization and the first challenge stirred

关键词： Breast cancer Pharmacology Drug screening assays,antitumor Freund's adjuvant shugan Liangxue prespriction

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疏肝滋肾汤治疗膝骨关节炎临床研究

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河北中医药学报 2016年第4期31卷 15-19页

作者：薄云唐山市丰润区第二人民医院唐山063000

目的:研究疏肝滋肾汤治疗膝骨关节炎的临床疗效。方法:80例患者随机分为2组,治疗组40例患者予疏肝滋肾汤,每次300 m L,早晚各1次;对照组40例给予非甾体抗炎药(NSAIDS)美洛昔康口服,1粒/次,1次/日,连服2月,应用WOMAC积分表、膝关节X线评... 详细信息

目的:研究疏肝滋肾汤治疗膝骨关节炎的临床疗效。方法:80例患者随机分为2组,治疗组40例患者予疏肝滋肾汤,每次300 m L,早晚各1次;对照组40例给予非甾体抗炎药(NSAIDS)美洛昔康口服,1粒/次,1次/日,连服2月,应用WOMAC积分表、膝关节X线评价,对比治疗前后、随访6月指标变化。结果:治疗组与对照组总有效率分别为90.0%、77.5%(P<0.05);2组WOMAC评价积分均下降,但治疗组效果明显优于对照组;2组膝关节X线评分均下降,治疗组优于对照组,差异有显著性。结论:疏肝滋肾汤治疗膝骨关节炎疗效确切,能有效缓解膝骨关节炎症状,且副作用少,安全可靠。

关键词：膝骨关节炎骨痹疏肝滋肾汤美洛昔康滋补肝肾通痹壮骨 shugan Zishen Tang ( decoction for soothing liver and nourishing kidney)

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