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Molecular signaling of 5-HT<sub>1A</sub>and presence of serotonergic cells in the fetal cerebral cortex

World Journal of Neuroscience 2013年第2期3卷 76-82页

作者： Alfonso B. M. de Oca Gabriel M. Gutiérrez Jorge H. Rodríguez Laboratorio de Neurontogenia Departamento de Fisiología Biofísica y Neurociencias Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Ciudad de México México Unidad de Investigación Biomolecular Hospital de Cardiología Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México

Early appearance of the serotonergic system in the fetal brain and the various effects of serotonin (5-HT) on brain morphogenesis, have given support to a neurotrophic role of serotonin. This function of serotonin is accomplished through a system of serotonin nerve terminals in the target regions that involves various 5-HT receptors. In visual, auditory and somatosensory cortex an early and intense serotonergic innervation is particularly important. The neuronal somata of these terminals are normally located in the mesencephalon and they have not been observed in the maturing cerebral cortex, neither in the adult brain. By using immunolabeling techniques, fluorescence and confocal microscopy, we observe the presence of both, 5-HT terminals and 5-HT cells in mesencephalon (Me, E17) and in the neopallium (Np, E13-E16) cocultures. Cells immunopositive to 5-HT and to tryptophan-5-hydroxilase are also observed in the Np on day 12 of culture. These results concerning the unexpected presence of serotonergic cells in the fetal cerebral cortex are interesting and may be of importance in corticogenesis. As it happens with other elements of the serotonergic system, the presence of these phenotypically serotonergic cells in the early cerebral cortex may be transitory and probably supporting cortex maturation processes. The molecular signaling path of the 5-HT1A receptor has also been identified.

关键词： serotonergic System Serotonin Receptor 5-HT1A Molecular Signaling Paths

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Intrauterine Exposure to Chronic 22 kHz Sound Affects Inhibitory Avoidance and serotonergic Parameters in Forebrain Areas of Dams and Rat Offspring

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Journal of Behavioral and Brain Science 2015年第2期5卷 25-39页

作者： Patrícia da Silva Oliveira Ariomester Nascimento Daniel Polliana Toledo Nunes Karina Abdo Costa Hani Camille Yehia Angela Maria Ribeiro Programa de Pós-Graduaç ã o em Neurociências Laboratório de Neurociências Comportamental e Molecular LaNeC Universidade Federal de Minas Gerais Belo Horizonte Brazil Departamento de Engenharia Eletrô nica Escola de Engenharia Universidade Federal de Minas Gerais Belo Horizonte Brazil Departamento de Bioquímica e Imunologia ICB and Departamento de Psicologia FaFiCH Laboratório de Neurociências Comportamental e Molecular LaNeC Universidade Federal de Minas Gerais Belo Horizonte Brazil

In the present study we evaluated the effects of chronic exposure to sounds at 22 kHz during pregnancy on the central serotonergic and behavioral parameters in Wistar rat dams after the suckling period and on their male rat offspring. In addition, we also assessed the effects of an acute 22 kHz sound, associated with the chronic intrauterine exposure, on the emotional responses of adult offspring. The primary hypothesis was that experiencing 22 kHz stimuli during an early stage of development would interfere with brain serotonergic parameters and, later, with the adult rat’s defensive responses. The corollary question was whether a 22 kHz sound exposure would differentially affect inhibitory avoidance and escape responses and central serotonergic parameters. Female rats were divided into four groups: non-pregnant control;non-pregnant chronic exposure;pregnant control;and pregnant chronic exposure. Male offspring were divided into four groups: chronic intrauterine sound exposure;acute sound exposure in adulthood;chronic intrauterine exposure with acute exposure in adulthood;and no exposure. Chronic sound exposure affected inhibitory avoidance and serotonergic parameters in female rats. For offspring, there was an interaction between chronic and acute sound exposure effects on inhibitory avoidance response but not on escape response. There were significant effects of chronic intrauterine exposure on serotonin turnover in the hippocampus and PFC of females. For offspring, the turnover was increased by chronic exposure only in PFC, and in amygdala it was increased by acute exposure. These results illuminate the potential of an early acoustic sound exposure for causing central serotonergic and emotional behavioral changes that can persist into later periods of life.

关键词： Intrauterine 22 kHz Sound Exposure Defensive Responses serotonergic Parameters Adult Offspring

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