Molecular signaling of 5-HT<sub>1A</sub>and presence of serotonergic cells in the fetal cerebral cortex
Molecular signaling of 5-HT<sub>1A</sub>and presence of serotonergic cells in the fetal cerebral cortex作者机构：Laboratorio de Neurontogenia Departamento de Fisiología Biofísica y Neurociencias Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Ciudad de México México Unidad de Investigación Biomolecular Hospital de Cardiología Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México
出 版 物：《World Journal of Neuroscience》 (神经科学国际期刊（英文）)
年 卷 期：2013年第3卷第2期
页 面：76-82页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Serotonergic System Serotonin Receptor 5-HT1A Molecular Signaling Paths
摘 要：Early appearance of the serotonergic system in the fetal brain and the various effects of serotonin (5-HT) on brain morphogenesis, have given support to a neurotrophic role of serotonin. This function of serotonin is accomplished through a system of serotonin nerve terminals in the target regions that involves various 5-HT receptors. In visual, auditory and somatosensory cortex an early and intense serotonergic innervation is particularly important. The neuronal somata of these terminals are normally located in the mesencephalon and they have not been observed in the maturing cerebral cortex, neither in the adult brain. By using immunolabeling techniques, fluorescence and confocal microscopy, we observe the presence of both, 5-HT terminals and 5-HT cells in mesencephalon (Me, E17) and in the neopallium (Np, E13-E16) cocultures. Cells immunopositive to 5-HT and to tryptophan-5-hydroxilase are also observed in the Np on day 12 of culture. These results concerning the unexpected presence of serotonergic cells in the fetal cerebral cortex are interesting and may be of importance in corticogenesis. As it happens with other elements of the serotonergic system, the presence of these phenotypically serotonergic cells in the early cerebral cortex may be transitory and probably supporting cortex maturation processes. The molecular signaling path of the 5-HT1A receptor has also been identified.
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