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Distributive characteristics of ser49gly and gly389Arg genetic polymor-phisms of β1-adrenoceptor in Chinese Han and Dai populations

引用

Acta Pharmacologica Sinica 2006年第2期27卷 254-258页

作者： Zhao-qian LIU Jie LIU Zhi-hua XIANG Min-yu HU Wei MO Lian-sheng WANG Dong-sheng OU-YANG Nan HE Dan WANG Hong-hao ZHOU Pharmacogenetics Research Institute,Institute of Clinical Pharmacology,Xiang-Ya School of Medicine.Central South University,Changsha 410078.China Pharmacogenetics Research Institute Institute of Clinical Pharmacology Xiang-Ya School of Medicine Central South University Changsha China

Aim:Genetic polymorphisms causing ser49gly and gly389Arg mutants of β1-adrenoceptor may result in significant changes in the function of this *** aim of the present study was to investigate the frequencies of the ser49glyand gly389Arg mutant alleles in healthy Chinese populations and to investigatethe differences between 2 Chinese ethnic groups(Han and Dai populations)withrespect to the frequencies of these ***:A total of 225 Han Chineseand 175 Dai Chinese unrelated healthy volunteers were recruited for this *** DNA was extracted from peripheral blood leukocytes by using a stan-dard manual chloroform-phenol *** spanning the 2 polymor-phisms were amplified by using polymerase chain reaction with template genomicDNA and relevant *** DNA products including the polymorphic lociwere subjected to restriction endonuclease digestion with Eco01091 and *** fragments were detected with an ultraviolet detector after electrophore-sis(100 V for approximately 1.5 h).Results:The frequencies of the gly49 andArg389 alleles were,respectively,16.2% and 76.4% in the Han population and 14.6%and 75.7% in the Dai ***:The polymorphisms causing theser49gly and gly389Arg mutations of the β1-adrenoceptor existed in both healthyHan and Dai Chinese *** frequencies of the ser49gly and gly389Argmutant alleles were not significantly different in the Han and Dai ***,the frequency of the gly389 variant seems to be significantly lower inthese 2 populations than in an African-American population.

关键词： β1-adrenoceptor genetic polymorphism ser49gly gly389Arg

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