Distributive characteristics of Ser49Gly and Gly389Arg genetic polymor-phisms of β1-adrenoceptor in Chinese Han and Dai populations

作     者：Zhao-qian LIU Jie LIU Zhi-hua XIANG Min-yu HU Wei MO Lian-sheng WANG Dong-sheng OU-YANG Nan HE Dan WANG Hong-hao ZHOU Pharmacogenetics Research Institute,Institute of Clinical Pharmacology,Xiang-Ya School of Medicine.Central South University,Changsha 410078.China 

作者机构：PharmacogeneticsResearchInstituteInstituteofClinicalPharmacologyXiang-YaSchoolofMedicineCentralSouthUniversityChangsha410078China 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2006年第27卷第2期

页      面：254-258页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：Project supported by the National Natural Science Foundation of China(№30070880) the Sponsorship for Outstanding Teachers Program,Ministry of Education,China(№2002-350) 

主　　题：β1-adrenoceptor genetic polymorphism Ser49Gly Gly389Arg 

摘      要：Aim:Genetic polymorphisms causing Ser49Gly and Gly389Arg mutants of β1-adrenoceptor may result in significant changes in the function of this *** aim of the present study was to investigate the frequencies of the Ser49Glyand Gly389Arg mutant alleles in healthy Chinese populations and to investigatethe differences between 2 Chinese ethnic groups(Han and Dai populations)withrespect to the frequencies of these ***:A total of 225 Han Chineseand 175 Dai Chinese unrelated healthy volunteers were recruited for this *** DNA was extracted from peripheral blood leukocytes by using a stan-dard manual chloroform-phenol *** spanning the 2 polymor-phisms were amplified by using polymerase chain reaction with template genomicDNA and relevant *** DNA products including the polymorphic lociwere subjected to restriction endonuclease digestion with Eco01091 and *** fragments were detected with an ultraviolet detector after electrophore-sis(100 V for approximately 1.5 h).Results:The frequencies of the Gly49 andArg389 alleles were,respectively,16.2% and 76.4% in the Han population and 14.6%and 75.7% in the Dai ***:The polymorphisms causing theSer49Gly and Gly389Arg mutations of the β1-adrenoceptor existed in both healthyHan and Dai Chinese *** frequencies of the Ser49Gly and Gly389Argmutant alleles were not significantly different in the Han and Dai ***,the frequency of the Gly389 variant seems to be significantly lower inthese 2 populations than in an African-American population.