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Protective effect of fasudil hydrochloride against acute renal injury in septicopyemia rats

Asian Pacific Journal of Tropical Medicine 2015年第12期8卷 1038-1041页

作者： Xing-Han Tian Wen-Shi Jiang Xiao-Li Li Mei-Feng Li Chao-Liang Liu Xiao-Xia Li Department of Critical Care Medicine Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College Emergency Department Yangshuo People's Hospital Emergency Department Affiliated Hospital of Jining Medical University

Objective:To observe the protective effect of fasudil hydrochloride against acute renal injury in septicopyemia ***:A total of 60 Wister rats were included in the study and divided into control group(n = 10),model group(n = 25) and treatment group(n = 25).Model group and treatment group received intraperitoneal injection of endotoxin(ET) to establish acute renal injury models while the control group only received daily intraperitoneal injection of normal saline 1 *** rats were taken out of model group and treatment group respectively at 1 h(T1),6 h(T2),12 h(T3),24 h(T4) and 48 h(T5),for intraperitoneal injection of ET 30 mg/*** group received intraperitoneal injection of fasudil hydrochloride 30 mg/kg 1 h before injection of *** three groups,5 mL blood samples were collected from postcava for determination of serum creatinine and urea nitrogen levels at different time *** of serum tumor necrosis factor and ET-1 were determined by using *** renal pathologic changes were observed under the ***:Serum creatinine levels in both model group and treatment group were significantly higher than control group at T2-T5(P < 0.05) while the levels in treatment group were significantly lower than control group at T3-T5(P < 0.05).At T2-T5,blood urea nitrogen levels in model group and treatment group were significantly higher than control group(P < 0.05) while the levels in treatment group were significantly lower than model group at T3-T5(P < 0.05).Concentrations of serum tumor necrosis factor in model group and treatment group were significantly higher than control group at T1-T5(P < 0.05) while the levels in treatment group were significantly lower than model group at T1-T5(P < 0.05).Serum ET-1 concentrations in model group and treatment group were significantly higher than control group at T1-T5(P <0.05) while the levels in treatment group at T1-T4 were significantly lower man model group(P <0.05).Rats in control gr

关键词： septicopyemia Acute renal injury Fasudil hydrochlo

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