Protective effect of fasudil hydrochloride against acute renal injury in septicopyemia rats

作     者：Xing-Han Tian Wen-Shi Jiang Xiao-Li Li Mei-Feng Li Chao-Liang Liu Xiao-Xia Li 

作者机构：Department of Critical Care MedicineYantai Yuhuangding Hospital Affiliated to Qingdao University Medical College Emergency DepartmentYangshuo People's Hospital Emergency DepartmentAffiliated Hospital of Jining Medical University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2015年第8卷第12期

页      面：1038-1041页

核心收录：

学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：Supported by Science and Technology Planning Project of Shandong Province under the fund(No.2014WS012) 

主　　题：Septicopyemia Acute renal injury Fasudil hydrochlo 

摘      要：Objective:To observe the protective effect of fasudil hydrochloride against acute renal injury in septicopyemia ***:A total of 60 Wister rats were included in the study and divided into control group(n = 10),model group(n = 25) and treatment group(n = 25).Model group and treatment group received intraperitoneal injection of endotoxin(ET) to establish acute renal injury models while the control group only received daily intraperitoneal injection of normal saline 1 *** rats were taken out of model group and treatment group respectively at 1 h(T1),6 h(T2),12 h(T3),24 h(T4) and 48 h(T5),for intraperitoneal injection of ET 30 mg/*** group received intraperitoneal injection of fasudil hydrochloride 30 mg/kg 1 h before injection of *** three groups,5 mL blood samples were collected from postcava for determination of serum creatinine and urea nitrogen levels at different time *** of serum tumor necrosis factor and ET-1 were determined by using *** renal pathologic changes were observed under the ***:Serum creatinine levels in both model group and treatment group were significantly higher than control group at T2-T5(P 0.05) while the levels in treatment group were significantly lower than control group at T3-T5(P 0.05).At T2-T5,blood urea nitrogen levels in model group and treatment group were significantly higher than control group(P 0.05) while the levels in treatment group were significantly lower than model group at T3-T5(P 0.05).Concentrations of serum tumor necrosis factor in model group and treatment group were significantly higher than control group at T1-T5(P 0.05) while the levels in treatment group were significantly lower than model group at T1-T5(P 0.05).Serum ET-1 concentrations in model group and treatment group were significantly higher than control group at T1-T5(P 0.05) while the levels in treatment group at T1-T4 were significantly lower man model group(P 0.05).Rats in control gr