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selenium nanoparticles Prepared from Reverse Microemulsion Process

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Chinese Chemical Letters 2004年第10期15卷 1249-1252页

作者： MingZhuLIU ShengYiZHANG YuHuaSHEN MingLiangZHANG SchoolofChemistryandChemicalEngineering AnhuiUniversityHefei230039

selenium nanoparticles were prepared by a reverse microemulsion system. Sodium selenosulfate was used as selenium source. The results showed that hydrochloric acid concentration and reaction temperature had great influence on the morphology of products. The crystalline selenium nanowires and amorphous selenium nanorods were obtained in given condition.

关键词： Reverse microemulsion selenium nanoparticles preparation.

In Vivo Studies and Flow Cytometric Investigation on Anticancer Potential of selenium nanoparticles Synthesized via Aqueous Extract of Clerodendron phlomidis

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Proceedings of Anticancer Research 2024年第1期8卷 71-81页

作者： Veeramani Subha Kirubanandan Shanmugam Renganathan Sahadevan National Centre for Nanoscience and Nanotechnology University of MadrasGuindy CampusChennai 600025Tamil NaduIndia Saveetha School of Engineering SIMATSThandalamChennai 602107Tamil NaduIndia Department of Biotechnology A.C.TechAnna UniversityChennai 600025Tamil NaduIndia

Nowadays,doctors and nutritionists recommend individuals incorporate selenium-rich foods such as nuts,cereals,and mushrooms into their regular diet to maintain fitness and overall *** nanoparticles(SeNPs)exhibit strong chemopreventive *** anticipations for SeNPs with enhanced and tunable bioactive activities have led to a keen interest in *** this study,the aqueous extract of Clerodendron phlomidis plant leaves was utilized for the synthesis of *** traditional Indian medicine,this plant extract is recognized as a significant anti-diabetic *** flavonoids tetrahydroxylflavone,7-hydroxyflavanone,and 6,4’-dimethyl-7-acetoxy-scutellarein present in this plant leaf extract demonstrate excellent anticancer *** secondary metabolites exhibit the ability to reduce sodium selenite into *** a concentration of 13μg/mL,the synthesized SeNPs effectively inhibited the proliferation of the HepG2 cell *** results suggest that the SeNPs possess promising anti-cancer potential against liver cancer and can be considered as a therapeutic agent for liver cancer ***,the cell cycle arrest induced by SeNPs was further confirmed by the fluorescence-activated cell sorting(FACS)method,indicating that SeNPs could efficiently differentiate cancer cells from normal ***,it showed a significant improvement in diethylnitrosamine(DEN)-induced Swiss Wistar rat *** scientific investigation highlights the high anti-cancer potential of SeNPs,positioning them as a promising therapeutic agent for liver cancer treatment.

关键词： selenium nanoparticles Green synthesis Liver cancer Clerodendron phlomidis Flow cytometry In vivo studies

Aggregation and stability of selenium nanoparticles: Complex roles of surface coating, electrolytes and natural organic matter

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Journal of Environmental Sciences 2023年第8期130卷 14-23页

作者： Sujuan Yu Hao Liu Rui Yang Wenjing Zhou Jingfu Liu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control Department of Environmental Science&EngineeringNorth China Electric Power UniversityBaoding 071000China

The application of selenium nanoparticles(SeNPs)as nanofertilizers may lead to the release of SeNPs into aquatic ***,the environmental behavior of SeNPs is rarely *** this study,using alginate-coated SeNPs(Alg-SeNPs)and polyvinyl alcohol-coated SeNPs(PVA-SeNPs)as models,we systematically investigated the aggregation and stability of SeNPs under various water ***-SeNPs were highly stable in mono-and polyvalent electrolytes,probably due to the strong steric hindrance of the capping ***-SeNPs only suffered from a limited increase in size,even at 2500 mmol/L NaCl and 200 mmol/L MgCl_(2),while they underwent apparent aggregation in CaCl_(2) and LaCl_(3) *** binding of Ca^(2+) and La^(3+) with the guluronic acid part in alginate induced the formation of cross-linking *** organic matter enhanced the stability of Alg-SeNPs in monovalent electrolytes,while accelerated the attachment of Alg-SeNPs in polyvalent electrolytes,due to the cation bridge *** long-term stability of SeNPs in natural water showed that the aggregation sizes of Alg-SeNPs and PVA-SeNPs increased to several hundreds of nanometers or above 10μm after 30 days,implying that SeNPs may be suspended in the water column or further settle down,depending on the surrounding water *** study may contribute to the deep insight into the fate and mobility of SeNPs in the aquatic *** varying fate of SeNPs in different natural waters also suggests that the risks of SeNPs to organisms living in diverse depths in the aquatic compartment should be concerned.

关键词： selenium nanoparticles Aggregation Stability Surface coating Electrolytes Natural organic matter

Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities

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Nano Research 2017年第11期10卷 3775-3789页

作者： Zhaohua Ping Ting Liu Hui Xu Yan Meng Wenhua Li Xiaojuan Xu Lina Zhang College of Chemistry amp Molecular Sciences Wuhan University Wuhan 430072 China Hubei Key Laboratory of Cell Homeostasis College of Life Sciences Wuhan University Wuhan 430072 China

Nanotechnologies have been exploited to develop safe and effective medicines and *** the present study,a novel functional nanomedicine constructed from a bioactive polysaccharide and selenium nanoparficles （SeNPs） was developed.A highly-branched [3-（1→3）-D-glucan （AF1） with high anti-tumor activity was used to self-assemble hollow nanofibers with an apparent average diameter of 92 nm;Se nanopartides were synthesized via the reduction of sodium *** results of light scattering,transmission electron microscopy,and X-ray diffraction demonstrated that the spherical SeNPs with a mean diameter of 46 nm were entrapped in the cavities of the AF1 hollow nanofibers through the formation of Se-O bonds between SeNPs and AF1,leading to the good dispersion and high stability in water for over 16 *** vitro and in vivo assays indicated that the AF1-Se nanocomposite had higher anti-tumor activities against breast ***,AF1-Se displayed a broad-spectrum inhibition against human cancers with low half maximal inhibitory concentration （IC50） values and low toxicity to normal ***,the inhibition ratio of AF1-Se against MCF-7 cancer cells reached 75% at a concentration of 200 μ***-1 with 29 μM Se content,much higher than that by treatment with AF1 alone,suggesting a strong synergic effect and nano ***,we developed a method for increasing the stability,anti-tumor activity,and safety of SeNPs by wrapping with bioactive polysaccharides.

关键词： selenium nanoparticles stability and dispersion bioactive polysaccharide anti-cancer activity synergistic effect

Green-synthetized selenium nanoparticles using berberine as a promising anticancer agent

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Journal of Integrative Medicine 2022年第1期20卷 65-72页

作者： Mohamed S.Othman Sofian T.Obeidat Amal H.Al-Bagawi Mohamed A.Fareid Alaa Fehaid Ahmed E.Abdel Moneim Basic Sciences Department Deanship of Preparatory YearUniversity ofHa'ilHail 2240Saudi Arabia Faculty of Biotechnology October University for Modem Science and ArtsGiza 12451Egypt Chemistry Department Faculty of ScienceUniversity of Ha%Hail 2240Saudi Arabia Department of Botany and Microbiology Faculty of ScienceAl-Azhar UniversityCairo 35527Egypt Forensic Medicine and Toxicology Department Faculty of Veterinary MedicineMansoura UniversityDakahlia 35516Egypt Zoology and Entomology Department Faculty of ScienceHelwan UniversityCairo 11795Egypt

Objective: The chemo-preventative and therapeutic properties of selenium nanoparticles(Se NPs) have been documented over recent decades and suggest the potential uses of Se NPs in medicine. Biogenic Se NPs have higher biocompatibility and stability than chemically synthesized nanoparticles, which enhances their medical applications, especially in the field of cancer therapy. This study evaluated the potential of green-synthetized Se NPs by using berberine(Ber) as an antitumor agent and elucidated the mechanism by which these molecules combat Ehrlich solid tumors(ESTs).Methods: Se NPs containing Ber(Se NPs-Ber) were synthesized using Ber and Na2 Se O3 and characterized with Fourier transform infrared spectroscopy. Sixty male Swiss albino mice were then acclimatized for one week, injected with Ehrlich ascites tumor cells, and divided into four groups: EST, EST + cisplatin(5 mg/kg), EST + Ber(20 mg/kg), and EST + Se NPs-Ber(0.5 mg/kg). At the end of a 16-day observation period, 12 mice from each group were euthanized to analyze differences in the body weight, tumor size,gene expression, and oxidative stress markers in the four groups. Three mice from each group were kept alive to compare the survival ***: Treatment with Se NPs-Ber significantly improved the survival rate and decreased the body weight and tumor size, compared to the EST group. Se NPs-Ber reduced oxidative stress in tumor tissue,as indicated by a decrease in the lipid peroxidation and nitric oxide levels and an increase in the glutathione levels. Moreover, Se NPs-Ber activated an apoptotic cascade in the tumor cells by downregulating the B-cell lymphoma 2(Bcl-2) expression rate and upregulating the Bcl-2-associated X protein and caspase-3 expression rates. Se NPs-Ber also considerably improved the histopathological alterations in the developed tumor tissue, compared to the EST ***: Our study provides a new insight into the potential role of green-synthesized Se NPs by using Ber as

关键词： selenium nanoparticles Berberine Ehrlich solid tumor Oxidative stress Apoptosis

Inhibition of H_(2)O_(2)-induced TM3 cell apoptosis by oxidative stress by lentinan functionalized selenium nanoparticles through JAK2/STAT-3 and P53 pathways

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BIOCELL 2023年第6期47卷 1397-1405页

作者： MIAOMIAO LI ZILIN ZHENG JUNYI KE JIEYI LUO FAN JIANG YANXIA QU BING ZHU YINGHUA LI LIANDONG ZUO Department of Andrology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510120China Center Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510120China

Background:Nano-selenium has been widely used in antiviral and anticancer therapy,and has the advantages of good targeting and low *** the first time,we combined male reproduction with nano-selenium to investigate its antioxidant *** study investigated the protective effect of lentinan functionalized selenium nanoparticles on oxidative stress injury of the hydrogen peroxide(H_(2)O_(2))-induced Leydig cell line,***:The suitable concentration of nano-selenium treatment to promote cell proliferation was also *** concentration of 4μM could significantly promote the growth of TM3 *** stress damage was caused using an 800μM concentration of hydrogen *** cells were divided into four groups:normal control group,oxidative stress treatment group,H_(2)O_(2)+SeNPs@LNT group,and SeNPs@LNT *** H_(2)O_(2)+SeNPs@LNT group was pretreated with 4μM of SeNPs@LNT for 12 h,followed by 800μM of H_(2)O_(2)for 8 ***:Nano-selenium could significantly promote the proliferation and viability of TM3 ***@LNT treatment increased the level of mitochondrial membrane potential in normal cells and slowed down the decline in mitochondrial membrane potential level caused by oxidative stress *** addition,the increase in reactive oxygen species caused by oxidative stress was inhibited by SeNPs@LNT *** apoptosis of TM3 cells was detected,and SeNPs@LNT alleviated the necrosis and apoptosis of TM3 cells induced by H_(2)O_(2).Nano-selenium plays a protective role against oxidative H_(2)O_(2)-induced stress injury in TM3 cells through the changes in the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway and P53 pathway,and the expression levels of other related proteins,protein kinase B(AKT)and ***:SeNPs@LNT exhibited good biological activity and antioxidant effect and can thus be used to protect the male reproductive system from oxidative stress.

关键词： selenium nanoparticles Lentinan ROS Antioxidant

Inhibition of H_(2)O_(2)-induced apoptosis of GC2-spg cells by functionalized selenium nanoparticles with lentinan through ROSmediated ERK/p53 signaling pathways

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BIOCELL 2023年第2期47卷 401-408页

作者： MIAOMIAO LI DANYANG CHEN JUNYI KE RUILIN ZHENG JINGYAO SU ZILIN ZHENG JIEYI LUO HANRAN MAI FAN JIANG YANXIA QU XIAOQIONG GU BING ZHU YINGHUA LI LIANDONG ZUO Department of Andrology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510120China Center Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510120China

AH_(2)O_(2)-induced oxidative stress injury cell model was established to investigate the antioxidant effect of nanoselenium on mouse spermatocyte lines and the regulation mechanism of the expression level and activity of seleniumcontaining antioxidant enzymes induced by oxidative stress.A safe and effective nano-drug system of functionalized selenium-containing nanoparticles(SeNPs)was developed with lentinan(LNT)(SeNPs@LNT).Mice spermatocyte line GC2-spg cells were treated with SeNPs@LNT(1,2,4,8,16,32μM)for 24-72 h to evaluate the cytotoxicity of ***2-spg cells were randomly divided into the following groups:control,hydrogen peroxide(H_(2)O_(2)),SeNPs@LNT,and H_(2)O_(2)+SeNPs@LNT groups.H_(2)O_(2)+SeNPs@LNT group was pretreated with SeNPs@LNT 4μM for 12 h,followed by H_(2)O_(2)600μM for 8 *** cell viability decreased in the H_(2)O_(2) group and increased significantly in the SeNPs@LNT *** with the H_(2)O_(2) group,the SeNPs@LNT+H_(2)O_(2) group exhibited obvious red fluorescence,indicating a higher level of mitochondrial membrane *** content of intracellular reactive oxygen species(ROS)in the SeNPs@LNT group reduced significantly,and the intensity of green fluorescence in the SeNPs@LNT+H_(2)O_(2) group decreased significantly compared with the H_(2)O_(2) group,indicating the inhibitory effect of SeNPs@LNT on the generation of ROS-induced oxidative *** activity of GPx and SOD increased significantly in the SeNPs@LNT *** expression of p53 decreased significantly under the intervention of nano-selenium,and GPx1 expression *** the oxidative stress group,the expressions of DNA damage-related proteins and apoptosis-related proteins were higher than those in other ***,SeNPs@LNT can promote GC2-spg cell proliferation,improve GPx and SOD activities,remove intracellular ROS,and reduce mitochondrial damage and functional abnormalities caused by oxidative stress by regulating the ERK and p53 protein ***@LNT

关键词： selenium nanoparticles Lentinan ROS Antioxidant

Testing Toxicity and Antidote Effect of selenium nanoparticles with <i>Paramecium caudatum</i>

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Open Journal of Animal Sciences 2021年第4期11卷 532-542页

作者： Khandsuren Badgar József Prokisch Institute of Animal Science Biotechnology and Nature Conservation Faculty of Agricultural and Food Sciences and Environmental Management University of Debrecen Debrecen Hungary Doctoral School of Animal Science University of Debrecen Debrecen Hungary

A simple method for assessment of the toxicity and antidote effect of selenium nanoparticles with Paramecium caudatum is presented. Light microscopy in combination with computerized video tracking is employed for the determination of the survival time of P. caudatum. Up to 800 mg/L, selenium nanoparticles are not acutely toxic. With respect to a potential antidote effect, the lethality of silver nanoparticles, silver nitrate, sodium hydrogen selenite, and sodium selenite to P. caudatum was decreased and survival time was extended upon pre-treatment with selenium nanoparticles. Taken together, these findings suggest that administration of selenium nanoparticles attenuates exposure to toxicants. Selenium nanoparticles could be a good functional additive for food management in animals.

关键词： selenium nanoparticles Toxicity Antidote Effect Paramecium caudatum

Inhibitory of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with Arbidol through ROS-mediated signaling pathways

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Inhibitory of H1N1 influenza virus-induced apoptosis by func...