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Three new secoiridoid glycosides from the flower buds of Lonicera japonica

Chinese Journal of Natural Medicines 2020年第1期18卷 70-74页

作者： YANG Ran HAO Hao LI Jia XUAN Jing XIA Ming-Feng ZHANG Yong-Qing Key laboratory of Natural Pharmaceutical Chemistry Shandong University of Traditional Chinese MedicineJinan 250200China Key laboratory of Pharmacology Shandong University of Traditional Chinese MedicineJinan 250200China

Three new secoiridoid glycosides,named lonijapoglycol A(1),aldosecolohanin C(2)and aldosecolohanin B(3),together with three known ones(4–6),have been isolated from the flower the buds of Lonicera *** the structures were identified by spectroscopic *** A(1)expressed significant anti-inflammatory activity to inhibit the release ofβ-glucuronidase induced by platelet-activating factor in rat polymorphonuclear leukocytes with an IC50 value of 3.76μmol·L^-1.

关键词： Lonicera japonica secoiridoid glycosides Spectroscopic analysis Anti-inflammatory activity

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Two new secoiridoid glycosides from the roots of Picrorhiza scrophulariiflora

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Chinese Chemical Letters 2008年第10期19卷 1224-1227页

作者： Lian Chun Zou Tong Fei Zhu Shu Cai Gan Da Cheng Wang Yu Zhang Xu Ming Deng College of Animal Science and Veterinary Medicine Jilin University Changchun 130062 China College of Chemistry Jilin University Changchun 130062 China Department of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China School of pharmacy Shenyang Pharmaceutical University Shenyang 110016 China

From the roots ofPicrorhiza scrophulariiflora, two new secoifidoid glycosides, named picrosecosides Ⅰ and Ⅱ （1, 2） have been isolated. Their structures were elucidated on the basis of chemical and spectropic evide... 详细信息

关键词： Picrorhiza scrophulariiflora secoiridoid glycosides Picrosecosides Ⅰ and Ⅱ

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Pharmacokinetic and Relative Bioavailability of Three secoiridoid glycosides in Beagle Dog Plasma After Oral Administration of Conventional and Enteric-Coated Capsules of Gentianella acuta Extract

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World Journal of Traditional Chinese Medicine 2021年第2期7卷 246-253页

作者： Zhi-Bin Wang Kai Li Meng Wang Gao-Song Wu Yu-Jin Bi Hai-Xue Kuang College of Pharmacy Key Laboratory of Chinese Materia Medica(Ministry of Education)Heilongjiang University of Chinese MedicineHarbin 150040China SunGen Pharma LLC303C Collage Road EastPrincetonNJ08540USA

Objective:To simultaneously investigate the pharmacokinetics of gentiopicroside,sweroside,and swertiamarin,which are constituents of Gentianella acuta,by developing and validating a simple,sensitive,and fast ultra-high-performance liquid chromatography–tandem mass spectrometry *** and Methods:Blood samples were collected from the forward limb veins of six beagle dogs following oral gavage with ***,the whole plant extract(39.90 mg/kg).Plasma samples were processed using liquid–liquid *** analytes and paeoniflorin(internal standard[IS])were separated using an Acquity?UPLC ethylene bridged hybrid amide column(2.1 mm×100 mm,1.7μm)with isocratic elution using a mobile phase consisting of acetonitrile and 0.1%formic acid in water(80:20,v/v)at a flow rate of 0.4 mL/*** was performed using multiple reaction monitoring of the fragmentation transitions at m/z 401.1→179.0,403.1→195.0,419.1→179.0,and 525.2→449.1 for gentiopicroside,sweroside,swertiamarin,and the IS,***:The linearity of the analytical response was good and the calibration curves were linear over concentration ranges of 1.20–192.0,0.40–159.0,and 0.20–209.3 ng/mL for gentiopicroside,sweroside,and swertiamarin,*** extraction recovery was in the range of 84.72%–91.34%,84.58%–93.43%,and 82.75%–91.37%for gentiopicroside,sweroside,and swertiamarin,***:The method was successfully used to evaluate the pharmacokinetic parameters of gentiopicroside,sweroside,and swertiamarin in beagle dogs.

关键词： Beagle dog Gentianella acuta pharmacokinetics secoiridoid glycosides ultra-high-performance liquid chromatography-tandem mass spectrometry

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Five new sucrose esters from the whole plants of Phyllanthus cochinchinensis

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Natural Products and Bioprospecting 2013年第2期3卷 61-65页

作者： Jian-Qiang ZHAO Yan-Ming WANG Dong WANG a Chong-Ren YANG Min XU Ying-Jun ZHANG State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Chemical investigation of the whole plants of Phyllanthus cochinchinensis(Euphorbiaceae)led to the isolation of five new sucrose benzoyl esters,3,6'-di-O-benzoylsucrose(1),3,6'-di-O-benzoyl-2'-O-acetylsucrose(2),3,6'-di-O-benzoyl-4'-O-acetylsucrose(3),3,6'-di-O-benzoyl-3'-O-acetylsucrose(4)and 3-O-benzoyl-6'-O-(E)-cinnamoylsucrose(5),together with two known secoiridoid glycosides,jasminoside(6)and jaslanceoside B(7).Their structures were established on the basis of detailed spectroscopic analysis and chemical method.

关键词： Phyllanthus cochinchinensis sucrose esters secoiridoid glycosides

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