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scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway

World Journal of Gastrointestinal Oncology 2021年第9期13卷 1164-1183页

作者： Na Li Fan Yang Dong-Yan Liu Jin-Tao Guo Nan Ge Si-Yu Sun Department of Hospice Care Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Medical Research Center Shengjing Hospital of China Medical UniversityBenxi 111700Liaoning ProvinceChina

BACKGROUND Pancreatic cancer is a highly malignant tumor of the gastrointestinal system whose emerging resistance to chemotherapy has necessitated the development of novel antitumor ***,a traditional Chinese medicine monomer with a wide range of pharmacological properties,has attracted considerable attention for its antitumor *** To explore the potential antitumor effect of scoparone on pancreatic cancer and the possible molecular mechanism of *** The target genes of scoparone were determined using both the bioinformatics and multiplatform *** effect of scoparone on pancreatic cancer cell proliferation,migration,invasion,cell cycle,and apoptosis was detected in *** expression of hub genes was tested using quantitative reverse transcription polymerase chain reaction(qRT-PCR),and the molecular mechanism was analyzed using Western *** in vivo effect of scoparone on pancreatic cancer cell proliferation was detected using a xenograft tumor model in nude mice as well as *** The hub genes involved in the suppression of pancreatic cancer by scoparone were obtained by network bioinformatics analyses using publicly available databases and platforms,including SwissTargetPrediction,STITCH,GeneCards,CTD,STRING,WebGestalt,Cytoscape,and Gepia;AKT1 was confirmed using qRT-PCR to be the hub *** Counting Kit-8 assay revealed that the viability of Capan-2 and SW1990 cells was significantly reduced by scoparone treatment exhibiting IC50 values of 225.2μmol/L and 209.1μmol/L,*** healing and transwell assays showed that scoparone inhibited the migration and invasion of pancreatic cancer ***,flow cytometry confirmed that scoparone caused cell cycle arrest and induced *** also increased the expression levels of Bax and cleaved caspase-3,decreased the levels of MMP9 and Bcl-2,and suppressed the phosphorylation of Akt without affecting total PI3K and ***

关键词： Pancreatic cancer scoparone Akt1 PI3K/Akt signaling pathway Bioinformatics analysis Xenograft tumor

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Chemical Constituents from Pericarpium Citri Reticulatae

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Chinese Herbal Medicines 2017年第1期9卷 86-91页

作者： Man-qin Fu Geng-sheng Xiao Ji-jun wu Yu-long Chen Bo Zou Ke-jing An Yu-juan Xu Key Laboratory of Functional Foods Ministry of Agriculture Guangdong Key Laboratory of Agricultural Products Processing Sericultural ＆ Agric-Food Research Institute Guangdong Academy of Agricultural Sciences Guangzhou 510610 China

Objective To study the chemical constituents from Pericarpium Citri Reticulatae （Citrus reticulata）. Methods The chemical constituents were isolated and purified by silica gel column, Sephadex LH-20, and ODS column chromatography. The structures were identified by spectral data. Results Nineteen compounds were isolated and identified as 4＇,5,6,7-tetramethoxyflavone （1）, 3,3＇,4＇,5,6,7,8-heptmethoxyflavone （2）, sinensetin （3）, 5-O-demethylnobiletin （4）, tangeretin （5）, nobiletin （6）, apigenin （7）, 5-O- desmethyltangeretin （8）, 5,7-dihydroxy-3,3＇,4＇,6-tetramethoxyflavone （9）, pachypodol （10）, 4＇,5,6,7-tetramethoxyflavanone （11）, 3＇,4＇,5,7,8-pentamethoxyflavanone （12）, agestricin C （13）, scoparone （14）, isoscopoletin （15）, hesperidin （16）, didymin （17）, methylhesperidine （18）, and naringin （19）. Conclusion Compounds 9-15 are obtained from this plant for the first time.

关键词： agestricin C Citrus reticulata isoscopoletin Pericarpium Citri Reticulatae scoparone

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