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A longitudinal study of sars-cov-2-infected patients reveals a high correlation between neutralizing antibodies and covID-19 severity

引用

Cellular & Molecular Immunology 2021年第2期18卷 318-327页

作者： vincent Legros Solène Denolly Manon vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto CIRI–Centre International de Recherche en Infectiologie Team EVIRUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Universitéde Lyon VetAgro SupMarcy-l’ÉtoileFrance Department of Infectious Agents and Hygiene University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Immunology University-Hospital of Saint-EtienneSaint-EtienneFrance CIRI–Centre International de Recherche en Infectiologie Team GIMAPUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Department of Infectious Diseases University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Occupational Medicine University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Intensive Care and Resuscitation(Réanimation G) University-Hospital of Saint-EtienneSaint-EtienneFrance Laboratoire Interuniversitaire de Biologie de la Motricité Universitéde LyonUniversitéJean MonnetSaint-EtienneFrance Department of Anesthesiology and Critical Care University-Hospital of Saint-EtienneSaint-EtienneFrance

Understanding the immune responses elicited by sars-cov-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for *** this study,using either live sars-cov-2 particles or retroviruses pseudotyped with the sars-cov-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 sars-cov-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive *** show that nAb titers correlated strongly with disease severity and with anti-spike IgG ***,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low *** found that nAb activity in sars-cov-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other ***,we found an absence of cross-neutralization between endemic coronaviruses and sars-cov-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against ***,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization ***,our results contribute to our understanding of the immune correlates of sars-cov-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of sars-cov-2 is warranted.

关键词： Antibody Pathogenesis Humoral response covID-19 sars-cov-2v

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