检索结果-南通市图书馆

Anti-tumor activity of rice bran hydrolysates on migration, invasion and angiogenesis

Asian Pacific Journal of Tropical Biomedicine 2021年第7期11卷 317-326页

作者： Suphanthip Phusrisom Laddawan Senggunprai Auemduan Prawan Sarinya Kongpetch Upa Kukongviriyapan Supawan Thawornchinsombut Sirithon Siriamornpun Theeraphan Chumroenphat Ronnachai Changsri Veerapol Kukongviriyapan Department of Pharmacology Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Physiology Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Food Technology Faculty of TechnologyKhon Kaen UniversityKhon Kaen 40002Thailand Department of Food Technology and Nutrition Faculty of TechnologyMahasarakham UniversityMahasarakham44150Thailand Chumphae rice Research Center Ministry of Agriculture and CooperativesKhon Kaen 40130Thailand

Objective:To investigate anti-tumor effect of rice bran hydrolysates(RBH)on proliferation,migration,invasion,and angiogenesis of cholangiocarcinoma(CCA)cells,and elucidate the underlying ***:RBH was prepared from Tubtim Chumprae rice(Oryza sativa L.)by hydrothermolysis followed by protease *** content in RBH was analyzed by high-performance liquid *** CCA cells,KKU-156,KKU-452,and KKU-100,were used to study the effects of RBH on proliferation,migration,invasion,and adhesion by wound healing,Transwell chamber,and fibronectin cell adhesion *** was evaluated using human umbilical vein endothelial *** associated with cancer progression were analyzed by immunobloting ***:RBH contained carbohydrates,proteins,lipids,and various phenolic compounds and *** did not inhibit CCA proliferation,but strongly suppressed migration,invasion,adhesion of CCA cells,and the formation of tube-like capillary structures of human umbilical vein endothelial ***,RBH downregulated phosphorylation of FAK,PI3K,and Akt,suppressed NF-κB nuclear translocation,decreased the expression of ICAM-1,vimentin and vascular endothelium growth factor(VEGF),and increased the expression of ***:RBH suppresses CCA cell migration and invasion and decreases expression of proteins involved in cancer *** is a potential food supplement for cancer prevention.

关键词： rice bran hydrolysates Ferulic acid CCA cells Proliferation Migration Invasion Adhesion Metastasis Angiogenesis NF-κB

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protective effects of rice bran hydrolysates on heart rate variability,cardiac oxidative stress,and cardiac remodeling in high fat and high fructose diet-fed rats

引用

Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 183-193页

作者： Ketmanee Senaphan Upa Kukongviriyapan Pisit Suwannachot Geerasak Thiratanaboon Weerapon Sangartit Supawan Thawornchinsombut Akkasit Jongjareonrak Division of Physiology Faculty of Veterinary MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Cardiovascular Research Group Khon Kaen UniversityKhon Kaen 40002Thailand Department of Physiology Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Food Technology Faculty of TechnologyKhon Kaen UniversityKhon Kaen 40002Thailand Faculty of Agro-Industry Chiang Mai UniversityChiang Mai 50100Thailand

Objective:To examine the ameliorative effect of rice bran hydrolysates(RBH)on metabolic disorders,cardiac oxidative stress,heart rate variability(HRV),and cardiac structural changes in high fat and high fructose(HFHF)-fed ***:Male Sprague-Dawley rats were daily fed either standard chow diet with tap water or an HFHF diet with 10%fructose in drinking water over 16 ***(500 and 1000 mg/kg/day)was orally administered to the HFHF-diet-fed rats during the last 6 weeks of the study *** the end of the treatment,metabolic parameters,oxidative stress,HRV,and cardiac structural changes were ***:RBH administration significantly ameliorated metabolic disorders by improving lipid profiles,insulin sensitivity,and hemodynamic ***,RBH restored HRV,as evidenced by decreasing the ratio of low-frequency to highfrequency power of HRV,a marker of autonomic *** oxidative stress was also mitigated after RBH supplementation by decreasing cardiac malondialdehyde and protein carbonyl,upregulating eNOS expression,and increasing catalase activity in the ***,RBH mitigated cardiac structural changes by reducing cardiac hypertrophy and myocardial fibrosis in HFHFdiet-fed ***:The present findings suggest that consumption of RBH may exert cardioprotective effects against autonomic imbalances,cardiac oxidative stress,and structural changes in metabolic syndrome.

关键词： rice bran hydrolysates Heart rate variability Cardiac remodeling Metabolic syndrome Oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：