Protective effects of rice bran hydrolysates on heart rate variability,cardiac oxidative stress,and cardiac remodeling in high fat and high fructose diet-fed rats

作     者：Ketmanee Senaphan Upa Kukongviriyapan Pisit Suwannachot Geerasak Thiratanaboon Weerapon Sangartit Supawan Thawornchinsombut Akkasit Jongjareonrak Ketmanee Senaphan;Upa Kukongviriyapan;Pisit Suwannachot;Geerasak Thiratanaboon;Weerapon Sangartit;Supawan Thawornchinsombut;Akkasit Jongjareonrak

作者机构：Division of PhysiologyFaculty of Veterinary MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Cardiovascular Research GroupKhon Kaen UniversityKhon Kaen 40002Thailand Department of PhysiologyFaculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Food TechnologyFaculty of TechnologyKhon Kaen UniversityKhon Kaen 40002Thailand Faculty of Agro-IndustryChiang Mai UniversityChiang Mai 50100Thailand 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2021年第11卷第5期

页      面：183-193页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Young Researcher Development Project of Khon Kaen University 2018 

主　　题：Rice bran hydrolysates Heart rate variability Cardiac remodeling Metabolic syndrome Oxidative stress 

摘      要：Objective:To examine the ameliorative effect of rice bran hydrolysates(RBH)on metabolic disorders,cardiac oxidative stress,heart rate variability(HRV),and cardiac structural changes in high fat and high fructose(HFHF)-fed ***:Male Sprague-Dawley rats were daily fed either standard chow diet with tap water or an HFHF diet with 10%fructose in drinking water over 16 ***(500 and 1000 mg/kg/day)was orally administered to the HFHF-diet-fed rats during the last 6 weeks of the study *** the end of the treatment,metabolic parameters,oxidative stress,HRV,and cardiac structural changes were ***:RBH administration significantly ameliorated metabolic disorders by improving lipid profiles,insulin sensitivity,and hemodynamic ***,RBH restored HRV,as evidenced by decreasing the ratio of low-frequency to highfrequency power of HRV,a marker of autonomic *** oxidative stress was also mitigated after RBH supplementation by decreasing cardiac malondialdehyde and protein carbonyl,upregulating eNOS expression,and increasing catalase activity in the ***,RBH mitigated cardiac structural changes by reducing cardiac hypertrophy and myocardial fibrosis in HFHFdiet-fed ***:The present findings suggest that consumption of RBH may exert cardioprotective effects against autonomic imbalances,cardiac oxidative stress,and structural changes in metabolic syndrome.