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Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes

Chinese Journal of Natural Medicines 2021年第10期19卷 741-749页

作者： WANG Xiao-He DAI Ce WANG Jun LIU Rui LI Lei YIN Zong-Sheng Department of Bone and Joint Surgery Institute of Orthopedic Diseasesthe First Affiliated HospitalJinan UniversityGuangzhou 510000China Department of Orthopedics the First Affiliated Hospital of Anhui Medical UniversityHefei 230000China

During the pathogensis of rheumatoid arthritis(RA),activated RA fibroblast-like synoviocytes(RA-FLSs)combines similar proliferative features as tumor and inflammatory features as osteoarthritis,which eventually leads to joint ***,it is imperative to research and develop new compounds,which can effectively inhibit abnormal activation of RA-FLSs and retard RA ***(Neo)is a major active component of flavonoid compounds with anti-inflammation and anti-oxidant *** this study,the anti-inflammation,anti-migration,anti-invasion,anti-oxidant and apoptosis-induced effects of Neo on RAFLSs were explored to investigate the underlying *** results suggested that Neo decreased the levels of interleukin IL-1β,IL-6,IL-8,TNF-α,MMP-3,MMP-9 and MMP-13 in ***,Neo blocked the activation of the MAPK signaling ***,treatment with Neo induced the apoptosis of FLSs,and inhibited the migration of *** was also found that Neo reduced the accumulation of reactive oxygen species(ROS)induced by TNF-α.Taken together,our results highlighted that Neo may act as a potential and promising therapeutic drug for the management of RA.

关键词： Neohesperidin rheumatoid-arthritis Fibroblast-like synoviocytes Inflammatory Oxidative stress MAPK

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Immune states: integrated views of immunity by combining traditional Chinese medicine and modern medicine

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Science China Life Sciences 2024年第10期67卷 2271-2273页

作者： Anlong Xu Yuxing Zhi School of Life Sciences and Qi-Huang School of Chinese Medicine Beijing University of Chinese Medicine School of Life Sciences Sun Yat-sen University

Human immune system is an extraordinarily complex physiological system composed of multiple anatomical systems,diverse tissues and molecules from macroscopic to microscopic level. Numerous cells and molecules collecti... 详细信息

关键词： rheumatoid-arthritis LUNG MICROBIOTA

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Deletion of IFT20 in early stage T lymphocyte differentiation inhibits the development of col agen-induced arthritis

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Bone Research 2014年第4期2卷 241-251页

作者： Xue Yuan Lee Ann Garrett-Sinha Debanjan Sarkar Shuying Yang Department of Oral Biology School of Dental MedicineUniversity at BuffaloThe State University of New YorkBuffaloNY 14214USA Department of Biochemistry School of Medicine and Biomedical SciencesUniversity at BuffaloThe State University of New YorkBuffaloNY 14203USA Laboratory for Biomaterials and Regenerative Therapeutics Department of Biomedical EngineeringUniversity at BuffaloThe State University of New YorkBuffaloNY 14260-2050USA Developmental Genomics Group New York State Center of Excellence in Bioinformatics and Life SciencesUniversity at BuffaloThe State University of New YorkBuffaloNY 14203USA

IFT20 is the smallest member of the intraflagellar transport protein（IFT） complex B. It is involved in cilia formation. Studies of IFT20 have been confined to ciliated cells. Recently, IFT20 was found to be also expressed in non-ciliated T cells and have functions in immune synapse formation and signaling in vitro. However, how IFT20 regulates T-cell development and activation in vivo is still unknown. We deleted the IFT20 gene in early and later stages of T-cell development by crossing IFT20flox/flox（IFT20f/f） mice with Lck-Cre and CD4-Cre transgenic mice, and investigated the role of IFT20 in T-cell maturation and in the development of T cell-mediated collagen-induced arthritis（CIA）. We found that both Lck-Cre/IFT20f/f and CD4-Cre/IFT20f/f mice were indistinguishable from their wild-type littermates in body size, as well as in the morphology and weight of the spleen and thymus. However, the number of CD4- and CD8-positive cells was significantly lower in thymus and spleen in Lck-Cre/IFT20f/f mice. Meanwhile, the incidence and severity of CIA symptoms were significantly decreased, and inflammation in the paw was significantly inhibited in Lck-Cre/IFT20f/f mice compared to Lck-Cre/IFT201/1littermates. Deletion IFT20 in more mature T cells of CD4-Cre/IFT20f/f mice had only mild effects on the development of T cells and CIA. The expression of IL-1b, IL-6 and TGF-b1 were significantly downregulated in the paw of Lck-Cre/IFT20f/f mice, but just slight decreased in CD4-Cre/IFT20f/f mice. These results demonstrate that deletion of IFT20 in the early stage of T-cell development inhibited CIA development through regulating T-cell development and the expression of critical cytokines.

关键词： INTRAFLAGELLAR TRANSPORT IFT NF-KAPPA-B rheumatoid-arthritis CELL DEVELOPMENT PRIMARY CILIUM KINESIN-II MICE EXPRESSION COMPLEX PROTEINS

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