Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes

作     者：WANG Xiao-He DAI Ce WANG Jun LIU Rui LI Lei YIN Zong-Sheng WANG Xiao-He;DAI Ce;WANG Jun;LIU Rui;LI Lei;YIN Zong-Sheng

作者机构：Department of Bone and Joint SurgeryInstitute of Orthopedic Diseasesthe First Affiliated HospitalJinan UniversityGuangzhou 510000China Department of Orthopedicsthe First Affiliated Hospital of Anhui Medical UniversityHefei 230000China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2021年第19卷第10期

页      面：741-749页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81672161) 

主　　题：Neohesperidin Rheumatoid-arthritis Fibroblast-like synoviocytes Inflammatory Oxidative stress MAPK 

摘      要：During the pathogensis of rheumatoid arthritis(RA),activated RA fibroblast-like synoviocytes(RA-FLSs)combines similar proliferative features as tumor and inflammatory features as osteoarthritis,which eventually leads to joint ***,it is imperative to research and develop new compounds,which can effectively inhibit abnormal activation of RA-FLSs and retard RA ***(Neo)is a major active component of flavonoid compounds with anti-inflammation and anti-oxidant *** this study,the anti-inflammation,anti-migration,anti-invasion,anti-oxidant and apoptosis-induced effects of Neo on RAFLSs were explored to investigate the underlying *** results suggested that Neo decreased the levels of interleukin IL-1β,IL-6,IL-8,TNF-α,MMP-3,MMP-9 and MMP-13 in ***,Neo blocked the activation of the MAPK signaling ***,treatment with Neo induced the apoptosis of FLSs,and inhibited the migration of *** was also found that Neo reduced the accumulation of reactive oxygen species(ROS)induced by TNF-α.Taken together,our results highlighted that Neo may act as a potential and promising therapeutic drug for the management of RA.