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A high-fiber diet synergizes with Prevotella copri and exacerbates rheumatoid arthritis

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Cellular & Molecular Immunology 2022年第12期19卷 1414-1424页

作者： Lingjuan Jiang Mengmeng Shang Shengnan Yu Yudong Liu Hui Zhang Yangzhong Zhou Min Wang Tingting Wang Hui Li Zhihua Liu Xuan Zhang Department of Medical Research Center National Science and Technology Key Infrastructure on Translational MedicinePeking Union Medical College HospitalDepartment of RheumatologyBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Department of Rheumatology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineClinical Immunology CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Department of Internal Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing100101China Institute for Immunology School of MedicineTsinghua UniversityBeijing100084China Tsinghua-Peking Center for Life Sciences Beijing100084China

Both preclinical and established rheumatoid arthritis(RA)patients display alterations in the gut *** *** preferentially enriched in a subset of RA ***,we isolated a Prevotella strain,*** RA,from the feces of RA patients and showed that colonization of *** RA exacerbated arthritis in a collagen-induced arthritis(CIA)*** the presence of *** RA colonization,a high-fiber diet exacerbated arthritis via microbial alterations and intestinal *** of *** together with a high-fiber diet enabled the digestion of complex fiber,which led to the overproduction of organic acids,including fumarate,succinate and short-chain fatty *** promoted proinflammatory responses in macrophages,and supplementation with succinate exacerbated arthritis in the CIA *** findings highlight the importance of dysbiosis when evaluating the effects of dietary interventions on RA pathogenesis and provide new insight into dietary interventions or microbiome modifications to improve RA management.

关键词： rheumatoid arthritis Dysbiosis Prevotella copri High-fber diet Microbiota-derived metabolites

Osteoimmunology research in rheumatoid arthritis:From single-cell omics approach

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Chinese Medical Journal 2023年第14期136卷 1642-1652页

作者： Nan Hu Jing Wang Bomiao Ju Yuanyuan Li Ping Fan Xinxin Jin Xiaomin Kang Shufang Wu Department of Rheumatology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Physiology and Pathophysiology School of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061China Center for Translational Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China

Cellular immune responses as well as generalized and periarticular bone loss are the key pathogenic features of rheumatoid arthritis(RA).Under the pathological conditions of RA,dysregulated inflammation and immune processes tightly interact with skeletal system,resulting in pathological bone damage via inhibition of bone formation or induction of bone *** omics technologies are revolutionary tools in the field of modern biological *** enable the display of the state and function of cells in various environments from a single-cell resolution,thus making it conducive to identify the dysregulated molecular mechanisms of bone destruction in RA as well as the discovery of potential therapeutic targets and ***,we summarize the latest findings of single-cell omics technologies in osteoimmunology research in *** results suggest that single-cell omics have made significant contributions to transcriptomics and dynamics of specific cells involved in bone remodeling,providing a new direction for our understanding of cellular heterogeneity in the study of osteoimmunology in RA.

关键词： rheumatoid arthritis Osteoimmunology Single-cell omics Single-cell RNA sequencing scATAC-seq

Hepatitis B virus reactivation in rheumatoid arthritis

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World Journal of Clinical Cases 2022年第1期10卷 12-22页

作者： Ya-Li Wu Jing Ke Bao-Yu Zhang Dong Zhao Center for Endocrine Metabolism and Immune Diseases Beijing Luhe HospitalCapital Medical UniversityBeijing 101149China

rheumatoid arthritis(RA)is an autoimmune disease characterized by proliferative synovitis,which can cause cartilage and bone damage as well as functional ***-modifying anti-rheumatic drugs have significantly improved the prognosis of RA ***,people with RA,when combined with hepatitis B virus(HBV)infection,may experience reactivation of HBV during treatment with anti-rheumatic *** outcome of HBV reactivation(HBVr)varies from liver inflammation to liver failure,while insufficient HBV screening in RA patients has been reported in various ***,it is necessary to identify patients at high risk before starting immunosuppressive *** immune response plays an important role in anti-HBV ***,most anti-rheumatic drugs exert an inhibitory effect on the body’s immune system,resulting in ***,it is necessary to conduct a comprehensive evaluation based on host factors,viral factors,and drug *** this paper,we summarize the mechanism of HBVr,the risk of HBVr caused by anti-rheumatic drugs,and the appropriate diagnosis and treatment process for RA patients so that clinicians can have a more comprehensive understanding of HBVr in RA patients.

关键词： rheumatoid arthritis Hepatitis B virus reactivation Disease-modifying antirheumatic drugs Risk factors

Pulmonary hypertension secondary to seronegative rheumatoid arthritis overlapping antisynthetase syndrome:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9851-9858页

作者： Cheng-Yan Huang Ming-Jie Lu Jia-Hua Tian Dai-Shun Liu Chun-Yan Wu Department of Respiratory Medicine The Third Affiliated Hospital of Zunyi Medical University(The First People’s Hospital of Zunyi)Zunyi 563000Guizhou ProvinceChina Clinical School Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Polyarthritis is the most frequent clinical manifestation in antisynthetase syndrome(ASS)forms of idiopathic inflammatory myositis and may be misdiagnosed as rheumatoid arthritis(RA),particularly in patients with seronegative RA(SNRA).It is unclear whether there is an overlap between ASS and RA,or if ASS sometimes mimics *** hypertension(PAH)is common in connective tissue diseases(CTDs).However,published reports on CTD-PAH do not include overlapping CTDs,and its incidence and impact on patient prognosis are *** SUMMARY We report the case of a 63-year-old woman who presented with a 3-mo history of symptom aggravation of recurrent symmetrical joint swelling and pain that had persisted for over 10 *** patient was diagnosed with RA and interstitial lung *** patient repeatedly presented to the hospital’s respiratory and rhe-umatology departments with arthralgia,plus shortness of breath after *** tests indicated that anti-CCP and RF remained negative,while anti-J0-1 and anti-Ro-52 were strongly *** was not until recently that we recognized that this could be an unusual case of SNRA with concurrent *** pain was relieved after regular anti-rheumatic *** computed tomography scans showed that pulmonary interstitial changes did not progress significantly over several years;however,they showed gradual widening of the pulmonary artery,and cardiac ultrasound indicated elevated pulmonary artery systolic *** prescribed treatment of PAH was not effective in improving shortness of *** Overlap of RA and ASS may be *** research is necessary to facilitate early diagnosis,effective evaluation,and prognosis.

关键词： rheumatoid arthritis arthritis Antisynthetase syndrome Pulmonary hypertension Pulmonary arterial hypertension Case report

Changes in rheumatoid arthritis under ultrasound before and after sinomenine injection

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World Journal of Clinical Cases 2022年第1期10卷 35-42页

作者： Yi-Min Huang Yu Zhuang Zhi-Ming Tan Department of Rheumatology and Immunology Huizhou Central People’s HospitalHuizhou 516001Guangdong ProvinceChina

BACKGROUND rheumatoid arthritis(RA)is a prevalent clinical autoimmune disease that is commonly treated with diclofenac and *** recent years,the application of traditional Chinese medicine in RA has received widespread attention;it promotes blood circulation,strengthens the immune system,and eliminates *** sinomenine preparation of Zhingqeng Fengtongning is studied as a possible treatment for patients with *** To explore the value of sinomenine injection into the articular cavity for the treatment of *** A total of 94 patients with RA treated from January 2019 to January 2021 were selected and divided into the study and control groups with 47 patients each using a simple random number table *** groups received conventional treatment with diclofenac sodium and methotrexate *** control group received diproxone and lidocaine by intra-articular administration while the study group received an intra-articular administration of the sinomenine preparation of Zhengqing Fengning and lidocaine.χ^(2) test was used to evaluate the therapeutic effect and synovial thickness,degree of pain through the visual analog scale(VAS),blood flow grade,arthroinflammatory indexes[rheumatoid factor(RF),C-reactive protein(CRP),and erythrocyte sedimentation rate(ESR)]before and after treatment in the two *** The total effective rate of the study group(93.62%)was higher than that of the control group(78.72%)(P0.05).After treatment,the synovial thickness and VAS score were significantly lower(P<0.05)in the study group than in the control group(2.05±0.59 mm vs 2.87±0.64 mm and 2.11±0.62 vs 2.90±0.79 scores,respectively).The rate of blood flow at grade 0 in the study group(76.60%)was higher than that in the control group(57.45%),and the rate of blood flow at grade I(10.64%)was lowe

关键词： rheumatoid arthritis Articular injection Sinomenine Ultrasonic changes Inflammatory factors Zhengqing Fengtongning

Major depressive disorders in patients with inflammatory bowel disease and rheumatoid arthritis

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World Journal of Clinical Cases 2023年第4期11卷 764-779页

作者： Maryam Bilal Haider Brinda Basida Jasleen Kaur Department of Internal Medicine Detroit Medical CenterWayne State UniversitySinai Grace HospitalDetroitMI 48235United States Department of Geriatrics Rohde Island Hospital/Brown UniversityProvidenceRI 02903United States Department of Rheumatology St.Mary’s Ascension/Central Michigan UniversitySaginawMI 48601United States

BACKGROUND Various immune-mediated inflammatory diseases consisting of inflammatory bowel disease(IBD)and rheumatoid arthritis(RA),are found to have a substantial societal burden,increased healthcare costs,and progressive *** suggest that patients with vs without comorbid depression have a more significant disability,a lower likelihood of remission,and reduced adherence to *** interleukin(IL)-1β,tumor necrosis factor-α,and IL-6 contribute to developing depression by the impaired physiological responses to stress,resulting in increased pain,fever,fatigue,and lack thereof of interest,and thus poor long-term *** study emphasizes the timely recognition of the prevalence of major depressive disorder(MDD)in patients with RA and IBD combined,thus preventing *** To identify the prevalence level and temporal trends of depression in hospitalized IBD-RA *** All adult hospitalized patients from January 2000 to December 2019 in the nationwide inpatient sample(NIS)were *** study population included all patients with a primary or secondary IBD-RA overlap disease using corresponding international classification of diseases(ICD)-9 and ICD-10 *** includes Crohn’s disease and ulcerative *** study population was divided into IBD-RA without MDD(controls)and IBD-RA with MDD(cases).For group comparison between MDD vs no MDD,we used Student’s t-test for continuous variables and RaoScott Chi-square tests for categorical *** univariate analyses,we used logistic regression,and for multivariate analysis,we used a weighted multi-level mixed-effects *** attested all hypotheses with two-tailed significance level of 0.05(P<0.05 was considered significant).The outcome is to examine the temporal trends and prevalence of depression in patients with IBD-RA by gender,race,and *** A total of 133315 records were identified with IBD-RA overlap,of which 26155 patients(19.62%)had *** the IBD-RA

关键词： Inflammatory bowel disease rheumatoid arthritis Depression Multimorbidity Epidemiology Demographics

Dimethylamino group modified polydopamine nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy

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Bioactive Materials 2022年第12期7卷 409-420页

作者： Ying Chen Yonglin Wang Xianfang Jiang Jinhong Cai Yuting Chen Hanji Huang Yuan Yang Li Zheng Jinmin Zhao Ming Gao Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affiliated Hospital of Guangxi Medical UniversityNanning530021China Guangxi Collaborative Innovation Center of Regenerative Medicine and Medical Bioresource Development and Application The First Affiliated Hospital of Guangxi Medical UniversityNanning530021China Department of Orthopedics The First Affiliated Hospital of Guangxi Medical UniversityNanning530021China Department of Oral Radiology College of Stomatology of Guangxi Medical UniversityNanning530021China Guangxi Key Laboratory of Regenerative Medicine International Joint Laboratory on Regeneration of Bone and Soft TissuesThe First Affiliated Hospital of Guangxi Medical UniversityNanning530021China

Excessive cell-free DNA(cfDNA)released by damaged or apoptotic cells can cause inflammation,impacting the progression of rheumatoid arthritis(RA).cfDNA scavengers,such as cationic nanoparticles(NPs),have been demonstrated as an efficient strategy for treating ***,most scavengers are limited by unfavorable biocompatibility and poor scavenging ***,by exploiting the favorable biocompatibility,biodegradability and bioadhesion of polydopamine(P),we modified P with dimethylamino groups to form altered charged DPs to bind negatively charged cfDNA for RA *** showed that DPs endowed with superior binding affinity of cfDNA and little cytotoxicity,which effectively inhibited lipopolysaccharide(LPS)stimulated inflammation in vitro,resulting in the relief of joint swelling,synovial hyperplasia and cartilage destruction in RA ***,DPs with higher DS of bis dimethylamino group exhibited higher positive charge density and stronger cfDNA binding affinity,leading to excellent RA therapeutic effect among all of the treated groups,which was even close to normal *** finding provides a novel strategy for the treatment of cfDNA-associated diseases.

关键词： Cell-free DNA Polydopamine rheumatoid arthritis Nucleic acid binding affinity Immunotherapy

Anti-arthritic effect of Distemonanthus benthamianus extracts against rheumatoid arthritis in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第10期12卷 411-420页

作者： William Yousseu Nana Ernest Allah Hoki Kwenteh Gilbert Ateufack Eric Gonzal Tsafack Stephanie FloreDjuichou Nguemnang Zenab Linda Fagni Njoya Albert Donatien Atsamo Vanessa Mba Matah Marthe CarineFlore Adjouzem Yacine Karelle Madjo Kouam Elvira Ngoufack Azanze Marius Mbiantcha Laboratory of Biology and Physiology of Animal Organisms Department of Biology of Animal OrganismsFaculty of ScienceThe University of Douala CameroonP.O.Box 24157DoualaCameroon Research Unit of Animal Physiology and Phytopharmacology Faculty of ScienceUniversity of DschangDschangCameroon Laboratory of Animal Physiology Faculty of ScienceUniversity of Yaounde IYaoundéCameroon

Objective:To evaluate the anti-arthritic effect of aqueous and methanolic extracts of Distemonanthus ***:Monoarthritis was induced by an injection of 0.3 mL zymosan A(0.9%NaCl,v/v)in the right posterior knee joints of ***,joint diameter and pain threshold were *** was induced by an intracaudal injection of complete Freund’s adjuvant and rats were treated from day 14 post 1st complete Freund’s adjuvant injection until 28 *** clinical,hematological,biochemical and oxidative stress parameters were *** addition,histological analysis of the knee joint was perfomed in both ***:The aqueous and methanolic extracts of Distemonanthus benthamianus at a dose of 500 mg/kg ameliorated zymosan A-induced monoarthritis,as evidenced by reduced joint diameter,increased pain threshold,as well as improved joint *** addition,both extracts of Distemonanthus benthamianus markedly increased body weight and pain threshold,while reducing paw edema in polyarthritic *** also led to a marked decrease in platelets and white blood cells(Prheumatoid arthritis.

关键词： Distemonanthus benthamianus rheumatoid arthritis Anti-arthritis Complete Freund’s adjuvant Hyperalgesia Inflammation Oxidative stress

Acquired coagulation dysfunction resulting from vitamin Kdependent coagulation factor deficiency associated with rheumatoid arthritis: A case report

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World Journal of Clinical Cases 2022年第1期10卷 236-241页

作者： Yan-Jing Huang Liang Han Jing Li Chao Chen Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Orthopaedics Hefeng Central HospitalEnshi 445800Hubei ProvinceChina

BACKGROUND rheumatoid arthritis(RA)is a common chronic inflammatory autoimmune disease with the main clinical feature of progressive joint synovial inflammation,which can lead to joint deformities as well as *** often causes damage to multiple organs and systems within the body,including the blood hemostasis *** reports have focused on acquired coagulation dysfunction resulting from vitamin K-dependent coagulation factor deficiency associated with *** SUMMARY A 64-year-old woman with a history of RA presented to our hospital,complaining of painless gross hematuria for 2 *** coagulation function tests showed increased prothrombin time,international normalized ratio,and activated partial thromboplastin *** blood coagulation factor(F)activity was detected(FII,7.0%;FV,122.0%;and FX,6.0%),indicating vitamin K-dependent coagulation factor *** and an activated partial thromboplastin time mixed correction experiment also suggested decreased coagulation factor ***,the patient was initially diagnosed with hematuria,RA,and vitamin K-dependent coagulation factor *** patient received daily intravenous administration of vitamin K120 mg,etamsylate 3 g,and vitamin C 3000 mg for 10 ***,oral leflunomide tablets and prednisone were administered for treatment of *** the treatment,the patient's symptoms improved markedly and she was discharged on day *** were no hemorrhagic events during 18 mo of *** RA can result in vitamin K-dependent coagulation factor deficiency,which leads to acquired coagulation *** K1 supplementation has an obvious effect on coagulation dysfunction under these circumstances.

关键词： Acquired coagulation dysfunction rheumatoid arthritis Coagulation factor deficiency Vitamin K-dependent Case report