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First detection of cutavirus DNA in stools of patients with rheumatic diseases in Guangzhou,China

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Virologica Sinica 2023年第6期38卷 860-867页

作者： Yongzhi Li Liting Zheng Huan He Husheng Xiong Jiaqi Chen Hengbiao Sun Caiyun Chen Qiushuang Li Jiaqi Fu Fei Wu Yuhan Gao Juxian Xian Minyi Liang Gang Xiao Qing Chen Guangdong Provincial Key Laboratory of Tropical Disease Research Department of EpidemiologySchool of Public HealthSouthern Medical UniversityGuangzhou510515China Clinical Laboratory of Third Affiliated Hospital of Southern Medical University Guangzhou510500China

Cutavirus(CuV)is a novel protoparvovirus possibly associated with diarrhea and cutaneous T-cell lymphomas.Patients with rheumatic disease are immunosuppressed and may be more vulnerable to pathogenic viruses.A descriptive study was conducted among hospitalized patients with rheumatic diseases and individuals undergoing medical health check-ups between June 2019 and June 2022 in Guangzhou,China.Stool samples of subjects were tested for CuV DNA.Demographic and fecal examination data of patients were obtained from electronic medical records.A total of 505 patients with rheumatic diseases and 244 individuals who underwent medical health check-ups were included in the study.Of the patients with rheumatic disease,5.74%[95%confidence interval(CI):4.03%–8.12%]were positive for CuV DNA,while no individual in the medical health check-up group was positive,indicating a close correlation between CuV and rheumatic disease.Men and patients with rheumatoid arthritis or ankylosing spondylitis,according to the disease classification,were more susceptible to being infected with CuV(P<0.01).After adjustments,being male remained the only significant factor,with an adjusted odd ratio(OR)of 4.4(95%CI:1.7–11.4,P=0.002).Phylogenetic analysis of the CuV VP2 sequences showed three diverse clades,one of which was segregated to be a single branching independent of previously known sequences,which is possible a new genotype.

关键词： Cutavirus(CuV) rheumatic diseases Prevalence Risk factor Genetic characterization

rheumatic diseases in Shantou area ：ten-year epidemiological study

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中华内科杂志 1998年第ZK期37卷 76-80页

作者：曾庆馀黄少弼陈韧周修国肖征余许敬才林秋强谢素和 DepartmentofRheumatology ShantouUniversityMedicalCollegeShantouGuangdong FirstAffiliatedHospitalofShantouUniversityMedicalCollege ChenghaiMunicipalHospital．

Objective To investigate the prevalence of rheumatic diseases in Shantou and their risk factors for development. Methods Five epidemiological surveys on 22 049 adults were perforned in 10 years. Positive questionnaire responders were examined medically. Results The response rate on examination was more than 98％. The frequency of common rheumatic symptoms in Shantou was lower than that in northern China. The prevalences of ankylosing spondylitis (AS), rheumatoid arthritis (RA ), osteoarthritis (OA), osteoporosis (OP) and gout were 0.20％-0.32％, 0.20％-0.26％, 8.3％-10.8％, 12.4％ and 0.15％-0.17％ respectively. The frequency of HLA-B27 was 4.1％ among general population and 90.6％ in those with ankylosing spondylitis. The most commonly involved sites of osteoarthritis were lumbar spine, neck, and knee joint; whilst hand and hip were rarely involved. The quantity of calcium intake was considered insufficient in 85％ of the subjects surveyed. Conclusion The prevalence of AS and RA was similar in Shantou and in North China. The prevalence of general rheumatic symptoms was lower in Shantou than that in Beijing. This difference might be related to the diversities in consciousness of seeking medical care, reduction of bone content, climate and ergonomics.

关键词： rheumatic diseases Epidemiology Prevalence

Burden of atrial fibrillation in patients with rheumatic diseases

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World Journal of Clinical Cases 2021年第14期9卷 3252-3264页

作者： Muhammad Zubair Khan Kirtenkumar Patel Krunalkumar A Patel Rajkumar Doshi Vraj Shah Devina Adalja Zainulabedin Waqar Sona Franklin Neelesh Gupta Muhammad Hamdan Gul Shruti Jesani Steven Kutalek Vincent Figueredo Department of Internal Medicine St.Mary Medical CenterLanghornePA 19047United States Division of Cardiology North Shore University HospitalManhassetNY 11030United States Department of Internal Medicine University of Nevada Reno School of MedicineRenoNV 89502United States Division of Cardiology Medical College of BarodaBaroda 390001India Department of Internal Medicine GMERS Gotri Medical CollegeVadodara 390021India Department of Internal Medicine Mercy St.Vincent Medical CenterToledoOH 43608United States Department of Internal Medicine Nazareth HospitalPhiladelphiaPA 19115United States Department of Internal Medicine Saint Joseph HospitalChicagoIL 60657United States Department of Internal Medicine Trinitas Regional Medical CenterElizabethNJ 07202United States Department of Cardiology St.Mary Medical CenterLanghornePA 19047United States

BACKGROUND Studies have suggested that atrial fibrillation(AF)in patients with rheumatic diseases(RD)may be due to inflammation.determine morbidity and mortality associated with AF in hospitalized patients with RD.METHODS The National inpatient sample database from October 2015 to December 2017 was analyzed to identify hospitalized patients with RD with and without AF.A subgroup analysis was performed comparing outcomes of AF among different RD.RESULTS The prevalence of AF was 23.9%among all patients with RD(n=3949203).Among the RD subgroup,the prevalence of AF was highest in polymyalgia rheumatica(33.2%),gout(30.2%),and pseudogout(27.1%).After adjusting for comorbidities,the odds of having AF were increased with gout(1.25),vasculitis(1.19),polymyalgia rheumatica(1.15),dermatopolymyositis(1.14),psoriatic arthropathy(1.12),lupus(1.09),rheumatoid arthritis(1.05)and pseudogout(1.04).In contrast,enteropathic arthropathy(0.44),scleroderma(0.96),ankylosing spondylitis(0.96),and Sjorgen’s syndrome(0.94)had a decreased association of AF.The mortality,length of stay,and hospitalization costs were higher in patients with RD having AF vs without AF.Among the RD subgroup,the highest mortality was found with scleroderma(4.8%),followed by vasculitis(4%)and dermatopolymyositis(3.5%).CONCLUSION A highest association of AF was found with gout followed by vasculitis,and polymyalgia rheumatica when compared to other RD.Mortality was two-fold higher in patients with RD with AF.

关键词： Atrial fibrillation rheumatic diseases Lupus Gout Scleroderma Vasculitis

rheumatic diseases in Shantou area ：ten-year epidemiological study

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中华内科杂志 1998年第Z1期 80页

作者：曾庆馀黄少弼陈韧周修国肖征余许敬才林秋强谢素和 DepartmentofRheumatology ShantouUniversityMedicalCollegeShantouGuangdong ChenghaiMunicipalHospital． FirstAffiliatedHospitalofShantouUniversityMedicalCollege

关键词： rheumatic diseases Epidemiology Prevalence

Laboratory evaluation in rheumatic diseases

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World Journal of Methodology 2017年第1期7卷 1-8页

作者： Murat Birtane Sel?uk Yavuz Nurettin Ta?tekin Department of Physical Medicine and Rehabilitation Faculty of MedicineTrakya University

Autoantibodies can help clinicians to allow early detection of autoimmune diseases and their clinical manifestations, to determine effective monitoring of prognosis and the treatment response. From this point, they have a high impact in rheumatic disease management. When usedcarefully they allow rapid diagnosis and appropriate treatment. However, as they may be present in healthy population they may cause confusion for interpreting the situation. False positive test results may lead to wrong treatment and unnecessary anxiety for patients. Autoantibody positivity alone does not make a diagnosis. Similarly, the absence of autoantibodies alone does not exclude diagnosis. The success of the test is closely related to sensitivity, specificity and likelihood ratios. So, interpretation of these is very important for a proper laboratory evaluation. In conclusion, in spite of the remarkable advances in science and technology, a deeply investigated anamnesis and comprehensive physical examination still continue to be the best diagnostic method. The most correct approach is that clinicians apply laboratory tests to confirm or exclude preliminary diagnosis based on anamnesis and physical examination. This review will discuss these issues.

关键词： Autoantibodies rheumatic diseases Autoimmune diseases Laboratory biomarkers Diagnostic markers

Transcranial direct current electrical stimulation in combination with aerobic exercise:A pilot study in post-COVID-19 systemic autoimmune rheumatic patients

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World Journal of Rheumatology 2023年第1期11卷 1-12页

作者： Rafael Giovani Missé Alexandre Moura dos Santos Isabela Bruna Pires Borges Marlise Sítima Mendes Simões Lorenza Rosa Silvério Bruna Lindoso Correia Ana Wook Sook Kim Aline Marques Caetano Sandra Gofinet Pasoto Carla Gonçalves Schahin Saad Diogo Souza Domiciano Clarice Tanaka Julia Maria D’Andrea Greve Abrahão Fontes Baptista Samuel Katsuyuki Shinjo Division of Rheumatology Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Departamento de Fisioterapia Fonoaudiologia e Terapia OcupacionalHospital das Clínicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloNúcleo de Assistência e Pesquisa em NeuromodulaçãoSao PauloBrazil Laboratório de Estudos do Movimento Instituto de Ortopedia e TraumatologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil

BACKGROUND Systemic autoimmune rheumatic diseases(SARDs)are a group of diseases with multiorgan involvement and a high prevalence of chronic pain and fatigue.Patients with SARDs and post-coronavirus disease 2019(COVID-19)syndrome experience aggravation of symptoms.In this context,it is essential to establish strategies to reduce chronic pain and fatigue and improve quality of life.AIM To assess the efficacy of transcranial direct current stimulation(tDCS)for the treatment of fatigue and pain-associated post-COVID-19 syndrome in patients with SARDs.METHODS This study included nine patients with different types of SARDs.All patients had reverse transcription-polymerase chain reaction(RT-PCR)test confirmed COVID-19 as well as significant,persistent fatigue and pain that began to worsen after infection.Anodal tDCS was administered in five daily sessions(2mA,20 min).Concomitantly,patients were involved in aerobic exercise program.All participants were evaluated using specific questionnaires and strength assessment by handgrip and physical function by timed-up-and-go test and sit-to-stand test at baseline(within one week before tDCS protocol),and one week after tDCS protocol.During all procedures,the patients’treatments remained unchanged.RESULTS The sample comprised eight women and one man with a mean age of 48.7±9.6 years.After the tDCS protocol,pain and fatigue significantly improved on the visual analog scale(P<0.05).The physical function also improved 9.5±2.7 vs 6.8±0.8(P=0.001)for timed-up-go-test and 10.3±3.7 vs 15.1±4.0(P=0.037)for sit-to-stand test.None of the patients experienced any adverse events.CONCLUSION The present study showed that tDCS in combination with aerobic exercise was effective in improving physical function,and reducing fatigue/pain in SARDs patients with post-COVID-19 syndrome.

关键词： Autoimmune diseases COVID-19 Fatigue Neuromodulation Physical function rheumatic diseases Pain

The association between vibration and vascular injury in rheumatic diseases:A review of the literature

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The association between vibration and vascular injury in rhe...

Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity

2015年度安徽省流行病与卫生统计学学术论坛

作者： Yu-Jie Wang Xiao-Lei Huang Jun-Wei Yan Ya-Nan Wan Bing-Xiang Wang Jin-Hui Tao Bing Chen Bao-Zhu Li Guo-Jun Yang Jing Wang Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical University Department of Rheumatology and Immunology Anhui Medical UniversityAnhui Provincial Hospital School of Basic Medicine Anhui Medical University

Vascular manifestations can be seen early in the pathogenesis of inflammatory rheumatic diseases.Animal experiments,laboratory and clinical findings indicated that acute or long-term vibration exposure can induce vascular abnormalities.Recent years,in addition to Raynaud’s phenomenon(RP),vibration as a risk factor for other rheumatic diseases has also received corresponding considered.This review is concentrated upon the role of vibration in the disease of systemic sclerosis(SSc).In this review,we are going to discuss the main mechanisms which are thought to be important in pathophysiology of vascular injury under the three broad headings of ‘‘vascular’’,‘‘neural’’ and ‘‘intravascular’’.Aspects on the vibration and vascular inflammation are briefly discussed.And the epidemiological studies related to vibration studies in SSc and other rheumatic diseases are taken into account.

关键词： Epidemiology inflammation rheumatic diseases vasculopathy vibration

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Cellular & Molecular Immunology 2021年第5期18卷 1122-1140页

作者： Georgios Sogkas Faranaz Atschekzei Ignatius Ryan Adriawan Natalia Dubrowinskaja Torsten Witte Reinhold Ernst Schmidt Department of Rheumatology and Immunology Hannover Medical SchoolHanoverGermany Hannover Medical School Cluster of Excellence RESIST(EXC 2155)HanoverGermany

In addition to susceptibility to infections,conventional primary immunodeficiency disorders(PIDs)and inborn errors of immunity(IEI)can cause immune dysregulation,manifesting as lymphoproliferative and/or autoimmune disease.Autoimmunity can be the prominent phenotype of PIDs and commonly includes cytopenias and rheumatological diseases,such as arthritis,systemic lupus erythematosus(SLE),and Sjogren’s syndrome(SjS).Recent advances in understanding the genetic basis of systemic autoimmune diseases and PIDs suggest an at least partially shared genetic background and therefore common pathogenic mechanisms.Here,we explore the interconnected pathogenic pathways of autoimmunity and primary immunodeficiency,highlighting the mechanisms breaking the different layers of immune tolerance to self-antigens in selected IEI.

关键词： Inborn errors of immunity Primary immunodeficiencies Autoimmunity rheumatic diseases

Leptin in immuno-rheumatological diseases

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Cellular & Molecular Immunology 2011年第3期8卷 203-212页

作者： Marta Vadacca Domenico PE Margiotta Luca Navarini Antonella Afeltra Department of Rheumatology and Clinical Medicine University Campus Bio-MedicoRomeItaly

Leptin is one of the most important hormones secreted by adipocytes,with a variety of physiological roles related to the control of metabolism and energy homeostasis.Since its discovery in 1994,leptin has attracted increasing interest in the scientific community for its pleiotropic actions.One of these functions is the relationship between nutritional status and immune competence.It structurally resembles proinflammatory cytokines,such as IL-6 and IL-12.The cytokine-like structural characteristic of leptin is implicative of its function in regulating immune responses.The role of leptin in regulating immune responses has been assessed in vitro as well as in clinical studies.It has been shown that disease conditions of reduced leptin production are associated with increased infection susceptibility.Conversely,immune-mediated disorders,such as autoimmune diseases,are associated with the increased secretion of leptin and the production of proinflammatory pathogenic cytokines.In this paper,we review the most recent advances of the role of leptin in immune-rheumatological diseases,and we discuss whether strategies aimed at modifying leptin levels could represent innovative and therapeutic tools for autoimmune disorders.

关键词： adipokines autoimmune diseases leptin rheumatic diseases