检索结果-南通市图书馆

retinal microvasculature is a potential biomarker for acute mountain sickness

Science China(Life Sciences) 2023年第6期66卷 1290-1302页

作者： Yuan Xie Diya Yang Alex S.Huang Yiquan Yang Ying Han Yunxiao Sun Kai Cao Huaizhou Wang Shizheng Wu Qiang Zhu Guozhong Wang Tianyi Wu Ningli Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing100730China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing100005China The Viterbi Family Department of Ophthalmology Shiley Eye InstituteUniversity of CaliforniaSan DiegoCA92121USA Department of Ophthalmology University of CaliforniaSan FranciscoCA94143USA Institution of Geriatric Qinghai Provincial Hospital Xining810007China Department of Ultrasound Beijing Tongren HospitalCapital Medical UniversityBeijing100730China Department of Hyperbaric and Hypobaric Chamber Civil Aviation General HospitalBeijing100025China National Key Laboratory of High Altitude Medicine China High Altitude Medical Research InstituteXining810012China

Increased cerebral blood flow resulting from altered capillary level autoregulation at high altitudes leads to capillary overperfusion and then vasogenic cerebral edema,which is the leading hypothesis of acute mountain sickness(AMS).However,studies on cerebral blood flow in AMS have been mostly restricted to gross cerebrovascular endpoints as opposed to the *** study aimed to investigate ocular microcirculation alterations,the only visualized capillaries in the central neural system(CNS),during early-stage AMS using a hypobaric *** study found that after high altitude simulation,the optic nerve showed retinal nerve fiber layer thickening(P=0.004–0.018)in some locations,and the area of the optic nerve subarachnoid space(P=0.004)*** coherence tomography angiography(OCTA)showed increased retinal radial peripapillary capillary(RPC)flow density(P=0.003–0.046),particularly on the nasal side of the *** AMSpositive group had the largest increases in RPC flow density in the nasal sector(AMS-positive,?3.21±2.37;AMS-negative,?0.01±2.16,P=0.004).Among multiple ocular changes,OCTA increase in RPC flow density was associated with simulated early-stage AMS symptoms(beta=0.222,95%CI,0.009–0.435,P=0.042).The area under the receiver operating characteristics curve(AUC)for the changes in RPC flow density to predict early-stage AMS outcomes was 0.882(95%CI,0.746–0.998).The results further confirmed that overperfusion of microvascular beds is the key pathophysiologic change in early-stage *** OCTA endpoints may serve as a rapid,noninvasive potential biomarker for CNS microvascular changes and AMS development during risk assessment of individuals at high altitudes.

关键词： optical coherence tomography angiography retinal microvasculature acute mountain sickness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Decreased retinal microvasculature densities in pterygium

引用

International Journal of Ophthalmology(English edition) 2021年第12期14卷 1858-1867页

作者： Feng Wang Qian-Min Ge Hui-Ye Shu Xu-Lin Liao Rong-Bin Liang Qiu-Yu Li Li-Juan Zhang Gui-Ping Gao Yi Shao Department of Ophthalmology Meizhou Pepole’s HospitalMeizhou 514000Guangdong ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityJiangxi Centre of National Clinical Ophthalmology Research CentreNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongShatinNew Territories 999077Hong KongChina

AIM:To investigate the retinal vascular network alterations in eyes of patients with ***:Totally 18 left eyes from 18 female pterygium patients and 18 left eyes from 18 female healthy control subjects were *** coherence tomography angiography(OCTA)images were generated of the superficial retinal layer and deeper retinal layer of the macular retina for each *** microvascular(MIR)and macrovascular(MAR)densities were calculated and MIR,MAR,and total microvascular(TMI)density was compared in the healthy control and pterygium ***:In pterygium group,in the superficial retinal layer,the vascular density in superficial MIR,superior right(SR),inferior right(IR),right(R),superficial central annuli(SC)1,SC2,and SC3 decreased significantly in the macular area(Pretinal layer,the density of deep total microvessel(DTMI),deeper MIR,SR,IR,R,DC2,and DC3 decreased significantly in macular area of pterygium patients(P0.05).CONCLUSION:OCTA findings suggest that pterygium patients present with decreased retinal MIR density,and the major vascular alterations occurr mainly on the bitamporal *** vascular density of the superficial SC1,SC2,SC3 adjacent to the foveal and deep layer of DC2,DC2 regions,significantly decreased.

关键词： retinal microvasculature density pterygium optical coherence tomography angiography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of obstructive sleep apnea on retinal microvasculature

引用

国际眼科杂志:英文版 2023年第10期16卷 1670-1675页

作者： Müjdat Karabulut Semai Bek Sinem Karabulut Aylin Karalezli Gülnihal Kutlu Ophthalmology Department Mugla Sitki Kocman University Training and Research HospitalMugla 48300Türkiye Neurology Department Mugla Sitki Kocman University Faculty of MedicineMugla 48300Türkiye Ophthalmology Department Mugla Sitki Kocman University Faculty of MedicineMugla 48300Türkiye

AIM:To detect retinal microvascular variations in obstructive sleep apnea syndrome ***:This prospective,observational case-control study included healthy controls and patients with mild,moderate,and severe obstructive sleep apnea *** parameters,foveal avascular area,and flow areas in macula-centered,6.00×6.00 mm2 scan size optical coherence tomography angiography images were ***:The control group had the highest whole image,parafoveal,and perifoveal vessel density among the groups in both superficial and the deep capillary plexus(all P<0.05).Rapid eye movement sleep apnoea-hypopnoea index was reversely correlated with whole(Rho=-0.195,P=0.034),parafoveal(Rho=-0.242,P=0.008),perifoveal(Rho=-0.187,P=0.045)vessel density in the superficial capillary plexus,and whole(Rho=-0.186,P=0.046),parafoveal(Rho=-0.260,P=0.004),perifoveal(Rho=-0.189,P=0.043)vessel density in the deep capillary plexus,though the mean and non-rapid eye movement sleep apnoeahypopnoea index related with only parafoveal vessel density in the superficial capillary plexus(Rho=-0.213,P=0.020;Rho=-0.191,P=0.038)and the deep capillary plexus(Rho=-0.254,P=0.005;Rho=-0.194,P=0.035).CONCLUSION:This study shows decreased vessel density and its reverse correlation with the apnoea-hypopnoea index in patients with obstructive sleep apnea syndrome.

关键词： apnoea-hypopnoea index deep capillary plexus obstructive sleep apnea superficial capillary plexus vessel density retinal microvasculature

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

retinal nerve fiber layer (RNFL) integrity and its relations to retinal microvasculature and microcirculation in myopic eyes

引用

Eye and Vision 2018年第1期5卷 223-232页

作者： Dongyi Qu Ying Lin Hong Jiang Yi Shao Yingying Shi Shriya Airen Giovanni Gregori Jianhua Wang Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiFLUSA State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouGuangdongChina Department of Neurology University of Miami Miller School of MedicineMiamiFLUSA College of Arts and Sciences University of MiamiMiamiFLUSA Department of Ophthalmology Bascom Palmer Eye Institute 1638 NW 10th AvenueMcKnight Building-Room 202AMiamiFL 33136USA

Background:The aim was to determine retinal nerve fiber layer function and its relations to retinal microvasculature and microcirculation in patients with ***:Polarization-sensitive optical coherence tomography(PS-OCT)was used to measure phase retardation per unit depth(PR/UD,proportional to the birefringence)of the retinal nerve fiber layer(RNFL).Optical coherence tomography angiography(OCTA)was used to measure macular vessel density analyzed using fractal *** addition,a retinal function imager(RFI)was used to measure macular blood flow velocities in arterioles and ***-two patients with moderate myopia(MM,refraction>3 andretinal blood flow velocities in arterioles and venules among groups(P>0.05).The macular vessel density in both superficial and deep vascular plexuses was significantly lower in the HM group than in the other two groups(P0.05).Conclusions:The impairment of the retinal nerve fiber birefringence in the HM group may be one of the independent features in high myopic eyes,which appeared not to relate to macular microvascular density and blood flow velocity.

关键词： Myopia retinal nerve fiber layer Polarization-sensitive optical coherence tomography retinal blood flow velocity retinal function imager retinal microvasculature Optical coherence tomography angiography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterisation of human non-proliferative diabetic retinopathy using the fractal analysis

引用

International Journal of Ophthalmology(English edition) 2015年第4期8卷 770-776页

作者： Stefan Tǎlu Dan Mihai Cǎlugǎru Carmen Alina Lupascu Discipline of Descriptive Geometry and Engineering Graphics Department of AET Faculty of Mechanical Engineering Technical University of Cluj-Napoca Discipline of Ophthalmology Department of Surgical Specialties and Medical Imaging Faculty of Medicine Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca Department of Mathematics and Informatics University of Palermo

· AIM: To investigate and quantify changes in the branching patterns of the retina vascular network in diabetes using the fractal analysis method.·METHODS: This was a clinic-based prospective study of 172 participants managed at the Ophthalmological Clinic of Cluj-Napoca, Romania, between January 2012 and December 2013. A set of 172 segmented and skeletonized human retinal images, corresponding to both normal(24 images) and pathological(148 images)states of the retina were examined. An automatic unsupervised method for retinal vessel segmentation was applied before fractal analysis. The fractal analyses of the retinal digital images were performed using the fractal analysis software Image J. Statistical analyses were performed for these groups using Microsoft Office Excel2003 and Graph Pad In Stat software.·RESULTS: It was found that subtle changes in the vascular network geometry of the human retina are influenced by diabetic retinopathy(DR) and can be estimated using the fractal geometry. The average of fractal dimensions D for the normal images(segmented and skeletonized versions) is slightly lower than the corresponding values of mild non-proliferative DR(NPDR) images(segmented and skeletonized versions).The average of fractal dimensions D for the normal images(segmented and skeletonized versions) is higher than the corresponding values of moderate NPDR images(segmented and skeletonized versions). The lowestvalues were found for the corresponding values of severe NPDR images(segmented and skeletonized versions).· CONCLUSION: The fractal analysis of fundus photographs may be used for a more complete understanding of the early and basic pathophysiological mechanisms of diabetes. The architecture of the retinal microvasculature in diabetes can be quantitative quantified by means of the fractal *** abnormalities on retinal imaging may elucidate early mechanistic pathways for microvascular complications and distinguish patients with DR from health

关键词： diabetic retinopathy fractal fractal dimension retinal image analysis retinal microvasculature

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：