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Using Network Pharmacology and Molecular Docking Tools to Investigate the Potential Mechanism of Ephedra-Gypsum in the Treatment of respiratory diseases

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World Journal of Traditional Chinese Medicine 2023年第2期9卷 150-159页

作者： Can Huang Ling Yuan Yang Niu Ya-Ting Yang Yi-Fan Yang Yi Nan Hong-Li Dou Joanna Japhet School of Chinese Medicine Ningxia Medical UniversityYinchuanNingxiaChina Pharmacy College of Ningxia Medical University YinchuanNingxiaChina Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuanNingxiaChina School of Marxism Shaanxi University of ChineseMedicineXianyangShaanxiChina

Objective:The objective of this study was to investigate the potential mechanisms of ephedra-gypsum in the treatment ofrespiratory diseases(RDs)using network pharmacology and molecular docking *** and Methods:The TCMSP and UniProt databases were used to mine the active components and targets of ephedra-gypsum,and the targets of RD were screened using the Online Mendelian Inheritance in Man(OMIM)and GeneCards *** protein-protein interaction network graph was created using the drug-disease intersection targets in the STRING *** network diagram was analyzed using Cytoscape 3.9.1's topology *** gene ontology(GO)and KEGG enrichment analyses were performed using the DAVID *** docking bioactivity validation of the main active components and core targets was performed using AutoDock and PyMOL ***:Twenty-four compounds were screened,and 113 drug-disease targets *** total,358 biological processes,67 molecular functions,38 cellular components of GO,and 139 pathways were *** docking analysis demonstrated the strong binding ability of tumor protein 53(TP53)-***:The core components of ephedra-gypsum,such as quercetin,luteolin,kaempferol,and CaSO_(4)·2H_(2)O,act on key targets,such as tumor necrosis factor(TNF),interleukin-6(IL-6),TP53,and IL-1β through cytokine-mediated signaling pathways,infiammatory responses,cell proliferation,and *** could be useful for the treatment of RD.

关键词： Ephedra-gypsum mechanistic studies molecular docking network pharmacology respiratory diseases

Association of emergency room visits for respiratory diseases with sources of ambient PM2.5

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Journal of Environmental Sciences 2019年第12期31卷 154-163页

作者： Rui Chi Hongyu Li Qian Wang Qiangrong Zhai Daidai Wang Meng Wu Qichen Liu Shaowei Wu Qingbian Ma Furong Deng Xinbiao Guo Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Emergency Department Peking University Third HospitalBeijing 100191China Chinese Academy fo r Environmental Planning Beijing 100012China Beijing Center for Disease Control and Prevention Beijing 100013China

Previous studies have reported associations of short-term exposure to different sources of ambient fine particulate matter(PM2.5)and increased mortality or hospitalizations for respiratory *** studies,however,have focused on the short-term effects of source-specific PM2.5 on emergency room visits(ERVs)of respiratory *** apportionment for PM2.5 was performed with Positive Matrix Factorization(PMF)and generalized additive model was applied to estimate associations between source-specific PM2.5 and respiratory disease *** association of PM2.5 and total respiratory ERVs was found on lag4(RR=1.011,95%CI:1.002,1.020)per interquartile range(76μg/m3)*** found PM2.5 to be significantly associated with asthma,bronchitis and chronic obstructive pulmonary disease(COPD)ERVs,with the strongest effects on lag5(RR=1.072,95%CI:1.024,1.119),lag4(RR=1.104,95%CI:1.032,1.176)and lag3(RR=1.091,95%CI:1.047,1.135),*** estimated effects of PM2.5 changed little after adjusting for different air *** primary PM2.5 sources were identified using PMF analysis,including dust/soil(6.7%),industry emission(4.5%),secondary aerosols(30.3%),metal processing(3.2%),coal combustion(37.5%)and traffic-related source(17.8%).Some of the sources were identified to have effects on ERVs of total respiratory diseases(dust/soil,secondary aerosols,metal processing,coal combustion and traffic-related source),bronchitis ERVs(dust/soil)and COPD ERVs(traffic-related source,industry emission and secondary aerosols).Different sources of PM2.5 contribute to increased risk of respiratory ERVs to different extents,which may provide potential implications for the decision making of air quality related policies,rational emission control and public health welfare.

关键词： Emergency room visits respiratory diseases PM2.5 Source apportionment

Correlation Analysis for the Attack of respiratory diseases and Meteorological Factors

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Chinese Journal of Integrative Medicine 2011年第8期17卷 600-606页

作者：张德山贺娟高思华胡保昆马师雷 Beijing Professional Weather Service Observatory Department of Basic Medicine Beijing University of Chinese Medicine

Objective：To investigate the relationship between respiratory diseases onset and the meteorological factors in the same period and in a specific ***：By using the data of daily incidence of respiratory diseases obtained from Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine from January 1, 1998 to December 31,2007,and the data of 16 items of meteorological factors（such as the average,maximum, and minimum temperatures,etc.,including meteorological factors derived） obtained from the Beijing Municipal Meteorological Observatory,mathematical statistical methods were applied to achieve the non-linear correlation analysis,or the correlation test,between the incidence of respiratory diseases and the time-related meteorological ***：The simple correlation coefficients of the relationship between the incidence of respiratory diseases and 9 meteorological elements,including the average values of temperature,maximum temperature,minimum temperature,degree of comfort,precipitation,vapor pressure,low cloud cover,change of vapor pressure,and change of wind speed,were all greater than 0.8286,in which one of the relationship between the incidence of respiratory diseases and the maximum temperature is as high as *** tests showed RRα=0.05 and FFα=***：The incidence of respiratory diseases was closely correlated to meteorological factors,such as air temperature,vapor pressure,precipitation,wind speed,*** a certain extent,this conclusion confirmed the scientificity and objectivity of the theory of five evolutive phases and six climatic factors（Wu Yun Liu Qi,五运六气） in Huang Di Nei Jing（黄帝内经,The Yellow Emperor＇s Canon of Internal Medicine）.

关键词： respiratory diseases meteorological factors degree of correlation Chinese medicine five evolutive phases and six climatic factors

Association between Air Cane Field Burning Pollution and respiratory diseases:A Bayesian Approach

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Journal of Environmental Protection 2013年第8期4卷 161-167页

作者： Jorge Alberto Achcar Mayara Piani Luna da Silva Sicchieri Edson Zangiacomi Martinez Department of Social Medicine Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoBrazil

respiratory diseases and air pollution are the goals of many scientific works, but studies of the relations between these diseases and cane field burning pollution are still not well studied in the literature. In this work, we consider the times between days of extrapolations of the number of daily hospitalizations due to respiratory diseases as our data. To analyze this data set, we introduce different statistical models related to burning focus pollution and their relations with the counting of hospitalizations due to respiratory diseases. Under a Bayesian approach and with the help of the free available WinBUGS software, we get posterior summaries of interest using standard MCMC (Markov Chain Monte Carlo) methods.

关键词： Hospitalization Counting Bayesian Models Times between Hospitalization Extrapolation Days respiratory diseases

Development of community health service-oriented computer-assisted information system for diagnosis and treatment of respiratory diseases

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Family Medicine and Community Health 2013年第4期1卷 1-9页

作者： Yuefang Wu Xin Yao Peili Sun Yong Hu Yuchuan Zhu Yin Hu Department of respiratory Medicine the First Affiliated Hospital with Nanjing Medical UniversityNanjingJiangsu Province210029China Nanjing University of Science and Technology Hospital NanjingJiangsu Province210094China Jiangsu Shengze Hospital SuzhouJiangsu Province215228China

Objective:Community health services are an emerging *** have found in practice that diagnosis and treatment of respiratory diseases in the community are *** respiratory department’s daily work involves a number of outpatient registration items and a vast *** routine manual operation is inefficient and it is not convenient to make effective statistical analysis of the outpatient data to identify the risk factors closely related to ***,it is imperative to process the outpatient information of patients with respiratory diseases effectively and efficiently in a unified manner by means of computer ***:The design and realization of the Community Health Service-oriented computerassisted Information System for Diagnosis and Treatment of respiratory diseases(CHS-DTRD)was completed as part of the community intervention study on bronchial asthma that was carried out jointly by the Nanjing First Hospital Affiliated to Nanjing Medical University and the Hospital of Nanjing University of Science&Technology,and based on 2 years of experience and the needs of an overall ***:The computer-assisted information system for diagnosis and treatment was developed using Java Server Page(JSP)technology and introducing the advanced Asynchronous JavaScript XML(AJAX)technique and MS-SQL Server was used in the background ***-DTRD was composed of eight functional modules(outpatient data maintenance,outpatient appointment,intelligent analysis for disease risk factors,query and statistics,data dictionary maintenance,database manipulation,access control,and system configuration).CHS-DTRD featured a friendly interface,convenient operation,and stability and ***:Community health-oriented diagnosis and treatment of respiratory diseases is simple,programmable,and intuitive,thus the workload of physicians is significantly reduced and the work efficiency is *** system facilitates an intelligent analysis

关键词： Community health service respiratory diseases Computer-assisted diagnosis and treatment,Intelligent analysis Browser/server

Changes in Life Expectancy of respiratory diseases from Attaining Daily PM_(2.5) Standard in China: A Nationwide Observational Study

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The Innovation 2020年第3期1卷 12-19页

作者： Yin Yang Jinlei Qi Zengliang Ruan Peng Yin Shiyu Zhang Jiangmei Liu Yunning Liu Rui Li Lijun Wang Hualiang Lin Department of Epidemiology School of Public HealthSun Yat-sen UniversityNo.74 Zhongshan Road 2Yuexiu DistrictGuangzhou 510080China National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionNo.27 Nanwei RoadXicheng DistrictBeijing 100050China

Although exposure to air pollution increases the risk of premature mortality and years of life lost(YLL),the effects of daily air quality improvement to the life expectancy of respiratory diseases remained *** applied a generalized additive model(GAM)to assess the associations between daily PM_(2.5) exposure and YLL from respiratory diseases in 96 Chinese cities during 2013–*** further estimated the avoidable YLL,potential gains in life expectancy,and the attributable fraction by assuming dailyPM_(2.5) concentration decrease to the air quality standards of China and World Health *** and national results were generated by random-effects meta-analysis.A total of 861,494 total respiratory diseases and 586,962 chronic obstructive pulmonary disease(COPD)caused death from 96 Chinese cities were recorded during study *** 10 mg/m3 increase of PM_(2.5) in 3-day moving average(lag02)was associated with 0.16(95%CI:0.08,0.24)years increment in life expectancy from total respiratory *** highest effect was observed in Southwest region with 0.42(95%CI:0.22,0.62)years increase in life *** attaining the WHO's Air Quality Guidelines,we estimated that an average of 782.09(95%CI:438.29,1125.89)YLLs caused by total respiratory death in each city could be avoided,which corresponded to 1.15%(95%CI:0.67%,1.64%)of the overall YLLs,and 0.12(95%CI:0.07,0.17)years increment in life *** results of COPD were generally consistent with total respiratory *** findings indicate that reduction in daily PM_(2.5) concentrations might lead to longer life expectancy from respiratory death.

关键词： FINE PARTICULATES YEARS OF LIFE LOST respiratory diseases CHRONIC OBSTRUCTIVE PULMONARY DISEASE CHINA

Analysis of Relationship between Meteorological Conditions and respiratory diseases in Xuzhou

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Meteorological and Environmental Research 2015年第5期6卷 16-20页

作者： An Di Sun Guangdong Peng Mingyan Lv Xiang Xuzhou Meteorological Bureau

Based on daily data of influenza-like cases from four sentinel hospitals as well as meteorological data in Xuzhou from October 2005 to May 2011, number of patients with respiratory diseases in Xuzhou was analyzed, and then relationship between meteorological factors and number of patients with respiratory diseases was discussed. The prediction model of number of patients with respiratory diseases in each month was established to forecast number of patients with respiratory diseases using meteorological data. The results show that people suffered from respiratory diseases more frequently in January and from June to September in Xuzhou. Meteorological factors correlated highly with number of patients with re- spiratory diseases are different due to the difference in climatic characteristics among various seasons. The prediction model could obtain good effect.

关键词： Xuzhou respiratory diseases Meteorological conditions Discrimination formula China

Impact of Environmental Factors on respiratory diseases in Fuxin City and Its Prediction

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Meteorological and Environmental Research 2023年第2期14卷 21-27页

作者： Haiyan SHU Ye FAN Xiaotong YANG Xiangyi CHANG Fuxin Meteorological Bureau Fuxin 123000China

Based on the daily data of visits for respiratory diseases in two grade A hospitals as well as meteorological factors and air pollution in Fuxin City from December 1, 2020 to November 31, 2021, PCA and RBF neural network were used to study the effects of meteorological factors and air pollution on respiratory diseases and predict them. The results showed that the number of daily visits was the largest in winter(accounting for 62.5%), followed by spring(15.2%), and it was the smallest in autumn(only 6.9%). The correlation between the number of daily visits and meteorological factors was higher than that of air pollution factors, and the correlation with temperature and ozone was the highest. The response coefficient of daily visits to each factor increased first and then decreased within 9 d, and the peak was 4-5 d behind. RBF and PCA-RBF neural network models were established to predict the number of daily visits, and the accuracy was 86.3% and 95.2%, respectively.

关键词： Meteorological factors Air pollution respiratory diseases PCA-RBF neural network Prediction Fuxin City

Advances in Single Nucleotide Polymorphisms of Vitamin D Metabolic Pathway Genes and respiratory diseases

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Journal of Advances in Medicine Science 2020年第3期3卷 25-30页

作者： Zhilu Li Honghai Li Saijia Li Yingjing Du Bingxin Xu Yuxuan Wang Yiyu Cai First Clinical College of Hainan Medical University HaikouHainan570100China School of Public Health Hainan Medical UniversityHaikouHainan570100China School of Tropical Medicine and Laboratory Hainan Medical UniversityHaikouHainan570100China

Vitamin D is a fat-soluble *** is an essential vitamin for human *** has a classical effect on regulating calcium and phosphorus *** in cellular and humoral immune processes by regulating the growth,differentiation and metabolism of immune cells.A large number of studies in recent years have shown that vitamin D deficiency increases the incidence of respiratory *** diseases mainly include bronchial asthma,chronic obstructive pulmonary disease,tuberculosis,acute upper respiratory tract infection and *** D metabolic pathway genes play a very important regulatory role in the transformation of vitamin D into active vitamin D,including CYP2R1,CYP27B1,CYP24A1,VDBP,VDR five *** polymorphism of genes is the molecular basis of individual differences and disease ***,this paper summarizes the research on single nucleotide polymorphism of vitamin D metabolic pathway gene and respiratory *** order to provide a new idea for future treatment.

关键词： Vitamin D metabolic pathway genes Single nucleotide polymorphisms respiratory diseases