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Inhibitory effects of cryptoporus polysaccharide on airway constriction, eosinophil release,and chemotaxis in guinea pigs

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Acta Pharmacologica Sinica 2004年第4期25卷 105-109页

作者： Xiao-yan ZHAO, Qiang-min XIE2, Ji-qiang CHEN, Chuan-kui KE3 Zhejiang respiratory Drugs Research Laboratory of State Drugs Administration of China, Medical School ofZhejiang University, Hangzhou 310031 3TSBIO Science& Technology Co,Ltd, Hangzhou 310006, China 浙江大学国家食品药品监督管理局呼吸药物研究实验室 Hangzhou 310031 TSBIO Science & Technology Co Ltd Hangzhou 310006

AIM: To study effects of cryptoporus polysaccharide (CP) on antigen-induced bronchoconstriction, eosinophil peroxidase (EPO) release in vivo, and on platelet activating factor (PAF)-induced eosinophil chemotaxis in vitro in guinea pig. METHODS: The asthma model of guinea pig was formed with ovalbumin (OVA). The changes of lung resistance (RL) and dynamic lung compliance (Cdyn), EPO level in bronchoalveolar lavage fluids (BALF) and eosino- phil migration were determined. RESULTS: Pretreatment of CP at doses of 3, 9, and 27 mg/kg by intragastric gavage (ig), qd for 10 d, inhibited early asthma response in a dose-dependent manner. Inhibitory rates of mean increase value from 1 to 30 min of RL were 34.8 %, 74.4 % (P<0.05), and 79.6 % (P<0.05), respectively. Inhibi- tory rate of mean reduction value of Cdyn were 22.9 %, 40.5 % (P<0.01), and 66.5 % (P<0.01), respectively. Pretreatment of CP at doses of 3, 9, and 27 mg/kg also inhibited late asthma response, and the reduction of EPO level in BALF were 3.1 %, 16.9 % (P<0.01), and 20.1 % (P<0.01), respectively. The inhibitory rates of CP at concentrations of 0.13, 1.3, 13, 130 nmol/L to eosinophil migration induced by PAF were 6.8 %, 17.2 % (P<0.05), 29.6 % (P<0.01), and 35.9 % (P<0.01). CONCLUSION: CP protects lung against increase of RL and reduction of Cdyn, decreases EPO level in the asthma model, and inhibits eosinophil chemotaxis induced by PAF. The results suggest that CP may be a novel antiinflammatory agent for the treatment of asthma and allergic diseases.

关键词： polysaccharide ovalbumin bronchoconstriction respiratory function tests eosinophil peroxidase platelet activating factor chemotaxis asthma guinea pig

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Efficacy of Yiqigubiao pill on chronic obstructive pulmonary disease in rats with the disease induced by lipopolysaccharide and cigarette-smoke fumigation

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Journal of Traditional Chinese Medicine 2020年第6期40卷 983-991页

作者： Jiang Lin Li Fengsen Sun Jianhui Huo Hairu Li Xiaoqin Li Hongmei Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region Urumqi830000China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To investigate the efficacy of Yiqigubiao pill(YQGB)on chronic obstructive pulmonary disease(COPD)in rats with the COPD induced by lipopolysaccharide(LPS)and cigarettesmoke ***:In this study,six groups of rats were set up,including control group,model group,positive control group(aminophylline)and YQGB(high,medium and low doses)*** injection of lipopolysaccharide(LPS)and cigarette-smoke fumigation induced COPD in *** general condition,incubation period and coughing times,lung function,level of inflammatory factors,leukocyte condition and pathological changes of bronchus and lung tissue were observed in rats of each ***:In the COPD rats,the latent period of coughing was shortened and the cough frequency was increased significantly;the pulmonary function was significantly decreased,which was manifested by the increased lung tissue resistance and respiratory system resistance,and the decreasing percentage of forced expiratory volume and forced expiratory volume in the 0.3 s(FEV0.3/FVC);the contents of tumor necrosis factor-alpha(TNF-α)and interleukin-4 in serum were obviously increased,and the NEUT%in bronchoalveolar lavage fluid was significantly *** could obviously prolong the latent period of cough,and reduce the cough frequency and the content of TNF-αin *** can also significantly reduce respiratory resistance and increase FEV0.3/FVC *** results of histopathology showed that YQGB significantly reduced the pathological changes of tracheal mucosa and lung caused by *** obviously increased level of AQP1,which was down-regulated in the COPD ***:YQGB could significantly improve the pulmonary function,reduce inflammation and alleviate lung and bronchial diseases in the COPD rats.

关键词： Pulmonary disease chronic obstructive respiratory function tests Bronchoalveolar lavage fluid Inflammatory cytokines Yiqigubiao pill

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Values of high-resolution computed tomography and pulmonary function tests in managements of patients with chronic hepatitis C virus infection

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World Journal of Gastroenterology 2004年第3期10卷 381-384页

作者： Oguzhan Okutan Zafer Kartaloglu Ahmet Ilvan Ali Kutlu Erkan Bozkanat Emir Silit GATA Haydarpasa Training Hospital Department of Pulmonary DiseasesIstanbulTurkey Gumussuyu Military Hospital Department of Pulmonary DiseasesIstanbulTurkey GATA Haydarpasa Training Hospital Department of RadiologyIstanbulTurkey

AIM:To investigate pulmonary involvement via pulmonary function tests (PFT) and high-resolution computed tomocjraphy (HRCT) in patients with chronic hepatitis C virus (HCV) infection. METHODS:Thirty-four patients with chronic HCV infection without diagnosis of any pulmonary diseases and 10 healthy cases were enrolled in the study,PFT and HRCT were performed in all cases. RESULTS:A decrease lower than 80% of the predicted value was detected in vital capacity in 9/34 patients,in forced expiratory volume in one second in 8/34 patients,and in forced expiratory flow 25-75 in 15/34 patients,*** monoxide diffusing capacity (DLCO) was decreased in 26/34 *** of interstitial pulmonary involvement were detected in the HRCT of 16/34 *** difference was found between controls and patients with HCV infection in findings of HRCT (X^2=4.7,P=0.003).Knodell histological activity index (KHAI) of 28/34 patients in whom liver biopsy was applied was 9.0±*** findings,PFT values and DLCO were not affected by KHAI in patients with HCV *** these patients,all the parameters were related with age. CONCLUSION:We suggest that chronic hepatitis C virus infection may cause pulmonary interstitial involvement without evident respiratory symptoms.

关键词： respiratory function tests Tomography, X-Ray Computed Adult Aged Female Hepatitis C, Chronic Humans Lung Diseases Male Middle Aged

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Inhibitory effect of acetamide-45 on airway inflammation and phosphodiesterase 4 in allergic rats

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Acta Pharmacologica Sinica 2005年第12期26卷 1492-1496页

作者： Kai WANG~2 Hua-hao SHEN~(2,4) Jun-chun CHEN~2 Zhong CHEN~3 2 respiratory Department,the Second Affiliated Hospital,Medical School of Zhejiang University,Hangzhou 310009 3 Department of Pharmacology,Medical School of Zhejiang University,Hangzhou 310031,China respiratory Department the Second Affiliated Hospital Medical School of Zhejiang University Hangzhou China Department of Pharmacology Medical School of Zhejiang University Hangzhou China

Aim:To determine the effects of acetamide-45 on respiratory function,airwayinflammation,and the activity of phosphodiesterase 4（PDE4）in allergic ***:Rats were sensitized by a single intramuscular injection with ovalbumin（OVA）and were challenged with ovalbumin applied by using an aerosol repeat-edly for 7 d after 2 ***-45 at concentrations of 5,10,or 30 mg/kg wasthen administered by intraperitoneal *** in dynamic lung compli-ance and lung resistance,the accumulation of inflammatory cells in bronchoalveolarlavage,PDE4 activity,and the concentration of interleukin-4 in rat lung tissuewere ***:Seven days of treatment with acetamide-45 preventedeosinophil accumulation in allergic *** doses of 5,10,and 30 mg/kg,aceta-mide-45 decreased lung resistance to 0.20±0.04,0.25±0.07,and 0.22±0.05cmH2O·s-1·mL-1,respectively（Prespiratory function and inhibit airway inflammation in thisanimal model,and the PDE4 activity of lung tissue was obviously ***-45 was an effective anti-inflammatory agent in respiratory inflammation,and the mechanism of its action might depend on inhibition of PDE4.

关键词： acetamide-45 3’,5’-cyclic nucleotide phosphodiesterase respiratory function tests eosinophils asthma

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Spirometric Reference Equations for Elderly Chinese in Jinan Aged 60-84 Years

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Chinese Medical Journal 2018年第9期131卷 1016-1022页

作者： Xin-Yu Tian Chun-Hong Liu De-Xiang Wang Xiu-Li Ji Hui Shi Chun-Yan Zheng Meng-Shuang Xie Wei Xiao Department of Pulmonary and Critical Care Medicine Qilu Hospital of Shandong University Jinan Shandong 250012 China Department of Pulmonary Disease Jinan Traditional Chinese Medicine Hospital Jinan Shandong 250012 China

Background：The interpretation of spirometry varies on different reference *** people are usually underrepresented in published predictive *** study aimed at developing spirometric reference equations for elderly Chinese in Jinan aged 60-84 years and to compare them to previous ***：The project covered all of Jinan city,and the recruitment period lasted 9 months from January 1,2017 to September 30,2017,434 healthy people aged 60-84 years who had never smoked （226 females and 208 males） were recruited to undergo *** capacity （VC）,forced VC （FVC）,forced expiratory volume in 1 s （FEV1）,FEV1/FVC,FEV1/VC,FEV6,peak expiratory flow,and forced expiratory flow at 25%,50%,75%,and 25-75% of FVC exhaled （FEF25%,FEF50%,FEF75%,and FEF25-75%） were *** equations for mean and the lower limit of normal （LLN） were derived using the lambda-mu-sigma *** between new and previous equations were performed by paired ***：New reference equations were developed from the *** LLN of FEV1/FVC,FEF25-75% computed using the 2012-Global Lung function Initiative （GLI） and 2006-Hong Kong equations were both lower than the new *** biggest degree of difference for FEV1/FVC was 19% （70.46% vs.59.29%,t =33.954,P 〈 0.01） and for maximal midexpiratory flow （MMEF,equals to FEF25-75%） was 22% （0.82 vs.0.67,t =21.303,P 〈 0.01）.The 1990-North China and 2009-North China equations predicted higher mean values of FEV1/FVC and FEF25-75% than the present *** biggest degrees of difference were-4% （78.31% vs.81.27%,t =-85.359,P 〈 0.01）and-60% （2.11 vs.4.68,t =-170.287,P 〈 0.01）,***：The newly developed spirometric reference equations are applicable to elderly Chinese in *** 2012-GLI and 2006-Hong Kong equations may lead to missed diagnoses of obstructive ventilatory defects and the small airway dysfunction,while traditional linear equations for all ages may lead to overdiagnosis.

关键词： Aged Reference Values respiratory function tests Spirometry

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Using quantitative CT to predict postoperative pulmonary function in patients with lung cancer

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Chinese Medical Journal 2005年第9期118卷 742-746页

作者： LIUFang HANPing FENGGan-sheng LIANGBo XIAOJie TIANZhi-liang LEIZi-qiao DepartmentofRadiology AffiliatedUnionHospitalTongjiMedicalCollegeHuazhongUniversityofSciencesandTechnologyWuhan430022China（LiuFHanPFengGSLiangBXiaoJTian

Background At present, the therapy for patients with lung cancer that achieves a high rate of cure is surgical resection at an early stage of the disease. The aim of this study is to evaluate quantitative computed tomography (QCT) for predicting postoperative pulmonary function in patients with lung cancer. Methods The data of thirty-one patients with lung cancer who underwent both pulmonary functional tests and QCT scan before operations were collected. A CT program was used to quantify the volume of whole lung parenchyma with attenuation of -910 HU to -600 HU, which was defined as total functional lung volume (TFLV). Similarly, the volume of lung (lobes or segments) with attenuation of -910 HU to -600 HU was defined as regional functional lung volume (RFLV). Forced vital capacity (FVC), forced expiratory volume in first second (FEV_1), FVC% and FEV_1% (ratio to reference values of the matched population) were obtained from preoperational pulmonary functional tests. According to the formula: predicted FVC (pre-FVC)=preoperative FVC×[1-(RFLV/TFLV)]; predicted FEV_1 (pre-FEV_1)=preoperative FEV_1×[1-(RFLV/TFLV)], we obtained values of predicted FVC, predicted FEV_1, predicted FVC% (pre-FVC/reference values of the matched population), and predicted FEV_1% (pre-FEV_1/reference values of the matched population). The paired t test and Pearson correlation test were used to assess significance of differences and correlations between CT predicted values and postoperative measured results of FVC, FEV_1, FVC% and FEV_1%. Results QCT predicted values correlated well with postoperative FVC, FEV_1, FVC% and FEV_1% ( r =0.873, 0.809, 0.849 and 0.801 respectively, all P function in patients undergoing pulmonary resection, regardless of the patients’ preoperative pulmonary functional status.

关键词： lung neoplasms computed tomography X-ray respiratory function tests

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Effect of breathing and Daoyin exercises on the quality of life in patients with chronic obstructive pulmonary disease

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Journal of Acupuncture and Tuina Science 2015年第6期13卷 353-360页

作者：陈麒史苗颜张炜田君韩丑萍 Pulmonary Disease Department Shuguang Hospital Shanghai University of Traditional Chinese Medicine

Objective： To observe the effect of breathing and Daoyin exercises on the quality of life in patients with stable chronic obstructive pulmonary disease（COPD） due to deficiency of the lung and kidney（grade II-III）.Methods： A total of 60 eligible cases were randomly allocated into a treatment group（n=30） and a control group（n=30） by random number table. Cases in the control group received routine Western medical treatment, whereas cases in the treatment group conducted breathing and Daoyin exercises in addition to routine Western medical treatment. Patients in both groups were treated for a total of 3 months. Then the observation was made on changes in pulmonary ventilation function, major clinical symptoms, modified Medical Research Council scale（m MRC）, distance in 6-minute walk test（6-MWT）, COPD assessment test（CAT） and efficacy satisfaction questionnaire for COPD（ESQ-COPD） before and after treatment. Results： After treatment, the total effective rate was 80.0% in the treatment group, versus 66.7% in the control group, showing a statistical difference（P〈0.05）. Patients in the treatment group obtained more significant improvement in coughing, sputum production, dyspnea and shortness of breath than those in the control group（P〈0.05）. Patients in the treatment group obtained more significant elevation in the forced expiratory volume in 1 second percentage of predicted value（FEV1%） and peak expiratory flow rate（PEF%） than those in the control group（P〈0.05）. Patients in the treatment group obtained lower m MRC score than those in the control group（P〈0.05）. Patients in the treatment group obtained longer 6-MWT distance than those in the control group（P〈0.05）. Patients in the treatment group obtained lower CAT score（P〈0.01） and higher ESQ-COPD score（P〈0.05） than those in the control group. Conclusion： Breathing and Daoyin exercises combined with routine Western medical treatment are effective for stable COPD（grade II-III） due to deficiency of the lung and kidney and can i

关键词： Physical and Breathing Exercises Research on Qigong Pulmonary Disease Chronic Obstructive respiratory function tests Peak Expiratory Flow Rate

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Influence of acupuncture on pulmonary function of patients with asthma： a review

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Journal of Acupuncture and Tuina Science 2018年第3期16卷 195-200页

作者： Wei Yu-ting Yan Xing-ke School of Acupuncture and Tuina Gansu University of Chinese MedicineLanzhou 730000China

Asthma is a common disease with recurrent onset which severely affects patients＇ quality of life. Acupuncture can improve pulmonary functions in asthma patients and thus treat this disorder. To summarize the status of acupuncture treatment for asthma, we have collected clinical literatures published in the recent 20 years and analyzed the influence of acupuncture on pulmonary functions in asthma patients from the aspects of frequently used points, needling techniques, manipulation and mechanisms to provide references for treating asthma with acupuncture.

关键词： Acupuncture Therapy Acupuncture Points Asthma respiratory function tests Forced Expiratory Volume Peak Expiratory Flow Rate Forced Vital Capacity Point Selection

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Effect and mechanism of application in canicular days plus enteral nutrition for cough variant asthma in kids

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Journal of Acupuncture and Tuina Science 2016年第5期14卷 333-339页

作者：郑苏罗强彭力胥婧穆敬平洪珏(译) Taihe Hospital of Shiyan City Affiliated to Hubei University of Medicine Hubei ProvinceShiyan 442000China 不详

Objective： To observe the clinical efficacy of application in canicular days plus enteral nutrition in treating cough variant asthma （CVA） in kids, and to explore its action mechanism. Methods： Following a randomized controlled single-blind parallel-group design, 138 eligible kids with CVA were randomized into an observation group, a canicular-day application group, and an enteral nutrition group, 46 kids in each group. The canicular-day application group was intervened by application in canicular days, the enteral nutrition group was by enteral feeding, and the observation group was by both canicular-day application and enteral feeding. The therapeutic efficacies were evaluated after a treatment course. Results： The recovery rate and total effective rate were respectively 50.0% and 98.0% in the observation group, versus 23.9% and 91.3% in the canicular-day application group, and 13.0% and 78.6% in the enteral nutrition group. The observation group was significantly superior to the other two groups （both P〈0.05）. In comparing the global symptom score, peak expiratory flow （PEF）, forced expiratory volume in one second （FEVl）, CD3^＋, CD4^＋, CD4^＋/CD8^＋, CD8^＋, hemoglobin （Hb）, total protein （TP）, albumin （ALB）, eosinophil cationic protein （ECP）, lipid peroxide （LPO）, leukotriene （LT）, body weight （BW）, triceps skin-fold （TSF）, and arm muscle circumference （AMC）, the observation group was significantly better than the other two groups （both P〈0.05）. Conclusion： Application in canicular days plus enteral nutrition can significantly improve the pulmonary function and symptoms in children＇s CVA, and the effect is possibly produced by regulating cellular immune system, enhancing Hb, TP, ALB, BW, TSF, AMC, and inhibiting the production of ECP, LPO, and LT.

关键词： Moxibustion Therapy Cough Asthma Enteral Nutrition Randomized Controlled Trials respiratory function tests Child

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Clinical effect observation on acupuncture for chronic obstructive pulmonary disease

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Journal of Acupuncture and Tuina Science 2015年第5期13卷 306-311页

作者：刘鲁炯史苗颜宋秀明张炜江淳涓韩丑萍 Pulmonary Disease Department Shuguang Hospital Shanghai University of Traditional Chinese Medicine

Objective： To observe the clinical effect of acupuncture on chronic obstructive pulmonary disease （COPD）, and the improvements of patients＇ pulmonary ventilation function and 6-minute walk test （6-MWT） distance. Methods： A total of 80 COPD patients [grade 3-4 in Global Initiative for Chronic Obstructive Lung Disease （GOLD）, qi deficiency of the lung and kidney in traditional Chinese medicine （TCM） pattern] were randomly allocated into a treatment group （n=40） and a control group （n=40）. Salmeterol Xinafoate and Fluticasone Propionate powder （Seretide, 50 μg/250 μg） for inhalation was used for basic treatment in both groups （once in the morning and once in the evening）. Patients in the treatment group received acupuncture at Feishu （BL 13）, Shenshu （BL 23）, *** （CV 6）, Guanyuan （CV 4）, Dingchuan （EX-B 1）, Danzhong （CV 17） and Zusanli （ST 36] twice a week for 3 months. After 3 months of treatment, clinical effects, lung ventilation functions and 6-MWT distance were observed and compared in the two groups. Results： After 3 months of treatment, the total effective rate was 95.0% in the treatment group, versus 80.0% in the control group, showing a statistical difference （P〈O.05）; the phlegm expectoration, dyspnea and shortness of breath were more significantly improved in the treatment group than those in the control group （P〈0.01, P〈0.05）; and the 6-MWT distance and forced expiratory volume in 1 second percentage of predicted value （FEV1%） were more significantly improved in the treatment group than those in the control group （P〈0.05, P〈0.01）. Conclusion： Seretide inhaler combined with acupuncture can improve signs and symptoms in COPD patients, increase the 6-MWT distance, imorove FEV1% and obtain better results than Seretide alone.

关键词： Acupuncture Therapy Pulmonary Disease, Chronic Obstructive respiratory function tests Heart function tests

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