Spirometric Reference Equations for Elderly Chinese in Jinan Aged 60-84 Years

作     者：Xin-Yu Tian Chun-Hong Liu De-Xiang Wang Xiu-Li Ji Hui Shi Chun-Yan Zheng Meng-Shuang Xie Wei Xiao Tian Xin-Yu;Liu Chun-Hong;Wang De-Xiang;Ji Xiu-Li;Shi Hui;Zheng Chun-Yan;Xie Meng-Shuang;Xiao Wei

作者机构：Department of Pulmonary and Critical Care Medicine Qilu Hospital of Shandong University Jinan Shandong 250012 China Department of Pulmonary Disease Jinan Traditional Chinese Medicine Hospital Jinan Shandong 250012 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2018年第131卷第9期

页      面：1016-1022页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 0907[农学-林学] 08[工学] 0829[工学-林业工程] 09[农学] 083202[工学-粮食、油脂及植物蛋白工程] 

基　　金：This study was supported by a grant from the National Natural Science Foundation of China (No. 81370148) 

主　　题：Aged Reference Values Respiratory Function Tests Spirometry 

摘      要：Background：The interpretation of spirometry varies on different reference *** people are usually underrepresented in published predictive *** study aimed at developing spirometric reference equations for elderly Chinese in Jinan aged 60-84 years and to compare them to previous ***：The project covered all of Jinan city,and the recruitment period lasted 9 months from January 1,2017 to September 30,2017,434 healthy people aged 60-84 years who had never smoked （226 females and 208 males） were recruited to undergo *** capacity （VC）,forced VC （FVC）,forced expiratory volume in 1 s （FEV1）,FEV1/FVC,FEV1/VC,FEV6,peak expiratory flow,and forced expiratory flow at 25%,50%,75%,and 25-75% of FVC exhaled （FEF25%,FEF50%,FEF75%,and FEF25-75%） were *** equations for mean and the lower limit of normal （LLN） were derived using the lambda-mu-sigma *** between new and previous equations were performed by paired ***：New reference equations were developed from the *** LLN of FEV1/FVC,FEF25-75% computed using the 2012-Global Lung Function Initiative （GLI） and 2006-Hong Kong equations were both lower than the new *** biggest degree of difference for FEV1/FVC was 19% （70.46% vs.59.29%,t =33.954,P 〈 0.01） and for maximal midexpiratory flow （MMEF,equals to FEF25-75%） was 22% （0.82 vs.0.67,t =21.303,P 〈 0.01）.The 1990-North China and 2009-North China equations predicted higher mean values of FEV1/FVC and FEF25-75% than the present *** biggest degrees of difference were-4% （78.31% vs.81.27%,t =-85.359,P 〈 0.01）and-60% （2.11 vs.4.68,t =-170.287,P 〈 0.01）,***：The newly developed spirometric reference equations are applicable to elderly Chinese in *** 2012-GLI and 2006-Hong Kong equations may lead to missed diagnoses of obstructive ventilatory defects and the small airway dysfunction,while traditional linear equations for all ages may lead to overdiagnosis.