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Stromal vascular fraction: Mechanisms and application in reproductive disorders

World Journal of Stem Cells 2025年第1期17卷 71-79页

作者： Zhi-Han Liu Qi-Qi Xie Jia-Lyu Huang Department of Clinical Medicine School of Queen MaryNanchang UniversityNanchang 330000Jiangxi ProvinceChina Center for reproductive Medicine Jiangxi Key Laboratory of Reproductive HealthJiangxi Maternal and Child Health HospitalJiangxi Branch of National Clinical Research Center for Obstetrics and GynecologyNanchang Medical CollegeNanchang 330000Jiangxi ProvinceChina Center for reproductive Medicine Jiangxi Maternal and Child Health HospitalJiangxi Branch of National Clinical Research Center for Obstetrics and GynecologyNanchang Medical CollegeNanchang 330008Jiangxi ProvinceChina

Stromal vascular fraction(SVF)is a complex mixture derived from adipose tissue,consisting of a variety of *** to its potential for tissue repair,immunomod-ulation,and support of angiogenesis,SVF represents a promising frontier in regenerative medicine and offers potential therapy for a range of disease *** this article,we delve into the mechanisms through which SVF exerts its effects and explore its potential applications in treating both male and female reproductive disorders,including erectile dysfunction,testicular injury,stress urinary incontinence and intrauterine adhesion.

关键词： Stromal vascular fraction Angiogenesis Inflammation Regenerative medicine reproductive disorders

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Asian Journal of Andrology 2014年第1期16卷 50-59页

作者： Konstantin Svechnikov Jan-Bernd Stukenborg Iuliia Savchuck Olle Sider Department of Women's and Children's Health Paediatric Endocrinology Unit Karolinska Institutet and University Hospital Stockholm Sweden

During the past few decades, scientific evidence has been accumulated concerning the possible adverse effects of the exposure to environmental chemicals on the well-being of wildlife and human populations. One large and growing group of such compounds of anthropogenic or natural origin is referred to as endocrine-disrupting chemicals （EDCs）, due to their deleterious action on the endocrine system. This concern was first focused on the control of reproductive function particularly in males, but has later been expanded to include all possible endocrine functions. The present review describes the underlying physiology behind the cascade of developmental events that occur during sexual differentiation of males and the specific role of androgen in the masculinization process and proper organogenesis of the external male genitalia. The impact of the genetic background, environmental exposures and lifestyle factors in the etiology of hypospadias, cryptorchidism and testicular cancer are reviewed and the possible role of EDCs in the development of these reproductive disorders is discussed critically. Finally, the possible direct and programming effects of exposures in utero to widely use therapeutic compounds, environmental estrogens and other chemicals on the incidence of reproductive abnormalities and poor semen quality in humans are also highlighted.

关键词： endocrine disrupters male (in)fertility reproductive disorders testis testicular steroidogenesis

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NLRP3 inflammasome:a new therapeutic target for high-risk reproductive disorders?

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Chinese Medical Journal 2021年第1期134卷 20-27页

作者： Feng Zhou Chao Li Song-Ying Zhang Department of Obstetrics and Gynecology.Sir Run Run Shaw Hospital Affiliated to School of Medicine Zhejiang UniversityKey Laboratory of Reproductive Dysfunction Management of Zhejiang ProvinceHangzhouZhejiang 310016China

The NOD-like receptor protein 3(NLRP3)inflammasome is a key regulator of the host’s immune response,and many immune and metabolic disorders are linked to its *** review aimed to investigate and clarify the relationship between this inflammasome and high-risk reproductive *** cited here were retrieved from PubMed up to August 2020 using the keywords"NLRP3"or"NALP3","caspase-1","endometriosis","gestational diabetes","interleukin(IL)-18","IL-1β","pre-eclampsia(PE)","preterm birth","polycystic ovarian syndrome(PCOS)","recurrent spontaneous abortion(RSA)",and combinations of these *** results show that NLRP3 inflammasome is associated with various high-risk reproductive disorders and many inflammatory factors are secreted during its activation,such as IL-1βinduced during the development of *** is also associated with activation of the NLRP3 inflammasome,especially in overweight *** also participates in the pathogenesis of RSA and is activated in fetal membranes before preterm *** placentas of pregnant women with PE show higher expression of the NLRP3 inflammasome,and gestational diabetes mellitus occurs simultaneously with its *** evidence suggest that the NLRP3 inflammasome plays an important role in female reproductive *** treatment and management methods targeting it might help reduce the incidence of such disorders and improve neonatal outcomes.

关键词： NLRP3 inflammasome Endometriosis Polycystic ovarian syndrome Recurrent spontaneous abortion Preterm birth Pre-eclampsia Gestational diabetes mellitus reproductive disorders

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Genetic factors of reproductive disorders in female

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reproductive and Developmental Medicine 2024年第3期8卷 186-195页

作者： Inna I.Mordovina Alina K.Chebanu Maksim Y.Donnikov Tatiana A.Sinyukova Lyudmila V.Kovalenko Larisa D.Belotserkovtseva Department of Obstetrics Gynecologyand PerinatologyMedical Institute of Surgut State UniversitySurgutRussian Federation Scientific and Educational Center Medical Institute of Surgut State UniversitySurgutRussian Federation Department of Pathophysiology and General Pathology Director of the Medical InstituteSurgut State UniversitySurgutRussian Federation Surgut Regional Clinical Center for Maternity and Childhood Protection SurgutRussian Federation

Successful reproduction in mammals requires gamete development,fertilization,and early embryonic *** in any of these processes can lead to infertility,recurrent miscarriages,and congenital *** clinical recognition of the genetic causes of female reproductive insufficiency using increasingly advanced genetic technologies poses a serious challenge for reproductive medicine in the 21st ***,the current literature on genetic factors involved in reproductive losses was summarized.A literature search was conducted using Web of Science,MEDLINE,and PubMed databases for articles written in English on the genetic causes of women’s reproductive health *** implementation of whole-exome and wholegenome sequencing is expected to identify numerous genetic factors responsible for oocyte *** will aid in increasing the likelihood of successful female reproductive function,improve the outcomes of assisted reproductive technologies,optimize treatment,and facilitate genetic diagnosis of patients.

关键词： Genetics Infertility reproductive disorders Premature ovarian insufficiency

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Can Helicobacter pylori infection influence human reproduction?

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World Journal of Gastroenterology 2014年第19期20卷 5567-5574页

作者： Elena Moretti Natale Figura Giulia Collodel Antonio Ponzetto Collodel Department of Molecular and Developmental MedicineUniversity of Siena53100 SienaItaly Department of Medical Surgical and Neurological SciencesUniversity of Siena and Policlinico S Maria alle Scotte53100 SienaItaly Department of Internal Medicine University of Torino10126 TorinoItaly

Helicobacter pylori (H. pylori) infection could be associated with extra-digestive diseases. Here, we report the evidences concerning the decrease in reproductive potential occurring in individuals infected by H. pylori, especially by strains expressing CagA. This infection is more prevalent in individuals with fertility disorders. Infected women have anti-H. pylori antibodies in cervical mucus and follicular fluid that may decrease sperm motility and cross react immunologically with spermatozoa, conceivably hampering the oocyte/sperm fusion. Infection by CagA positive organisms enhances the risk of preeclampsia, which is a main cause of foetus death. These findings are supported by the results of experimental infections of pregnant mice, which may cause reabsorption of a high number of foetuses and alter the balance between Th1 and Th2 cell response. Infected men have decreased sperm motility, viability and numbers of normally shaped sperm and augmented systemic levels of inflammatory cytokines, such as tumor necrosis factor-α, which may damage spermatozoa. In countries where parasitic infestation is endemic, detrimental effects of infection upon spermatozoa may not occur, because the immune response to parasites could determine a switch from a predominant Th1 type to Th2 type lymphocytes, with production of anti-inflammatory cytokines. In conclusion, the evidences gathered until now should be taken into consideration for future studies aiming to explore the possible role of H. pylori infection on human reproduction.

关键词： Antigenic mimicry Helicobacter pylori infection Human sperm Inflammatory cytokines Preeclampsia reproductive disorders

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