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renal pathology Images Segmentation Based on Improved Cuckoo Search with Diffusion Mechanism and Adaptive Beta-Hill Climbing

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Journal of Bionic Engineering 2023年第5期20卷 2240-2275页

作者： Jiaochen Chen Zhennao Cai Huiling Chen Xiaowei Chen José Escorcia-Gutierrez Romany F.Mansour Mahmoud Ragab College of Computer Science and Artificial Intelligence Wenzhou UniversityWenzhou325035China Department of Rheumatology and Immunology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Department of Computational Science and Electronics Universidad de la CostaCUC080002BarranquillaColombia Department of Mathematics Faculty of ScienceNew Valley University72511El-KhargaEgypt Information Technology Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Mathematics Faculty of ScienceAl-Azhar UniversityNaser CityCairo11884Egypt

Lupus Nephritis(LN)is a significant risk factor for morbidity and mortality in systemic lupus erythematosus,and nephropathology is still the gold standard for diagnosing LN.To assist pathologists in evaluating histopathological images of LN,a 2D Rényi entropy multi-threshold image segmentation method is proposed in this research to apply to LN images.This method is based on an improved Cuckoo Search(CS)algorithm that introduces a Diffusion Mechanism(DM)and an Adaptiveβ-Hill Climbing(AβHC)strategy called the DMCS algorithm.The DMCS algorithm is tested on 30 benchmark functions of the IEEE CEC2017 dataset.In addition,the DMCS-based multi-threshold image segmentation method is also used to segment renal pathological images.Experimental results show that adding these two strategies improves the DMCS algorithm's ability to find the optimal solution.According to the three image quality evaluation metrics:PSNR,FSIM,and SSIM,the proposed image segmentation method performs well in image segmentation experiments.Our research shows that the DMCS algorithm is a helpful image segmentation method for renal pathological images.

关键词： Multi-threshold image segmentation 2D Rényi entropy renal pathology Cuckoo search algorithm Swarm intelligence algorithms Bionic algorithm

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Potential of renal pathology on Refining Syndrome Typing of Chinese Medicine in IgA Nephropathy

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Chinese Journal of Integrative Medicine 2013年第2期19卷 92-97页

作者：李建军陈香美魏日胞 Department of Diagnosis of Chinese Medicine School of Basic Medical SciencesBeijing University of Chinese Medicine Institute of Nephrology and Key Laboratory General Hospital of People's Liberation Army

Objective： To investigate the potential of renal pathological index as a differential diagnosis factor for Chinese medicine （CM） syndromes typing in IgA nephropathy （IgAN）. Methods： A total of 1,016 patients with IgAN was recruited from November 2001 to November 2004. All the signs and symptoms including picture of the tongue and pulse tracings were collected. All patients were typed according to the CM syndrome typing scheme for chronic primary glomerulopathy. The severity of glomerulus and tubulointerstitial lesions （mild, moderate- severe） were evaluated using lee＇s grading system and the Katafuchi score system. Results： The syndrome types transform in turn by deficiency of both the Spleen （Pi） and Lung （Fei） qi, deficiency of both qi and yin, deficiency of Liver （Gan） and Kidney （Shen） yin and deficiency of Spleen-Kidney （Shen） yang, with the aggravation of pathogenetic condition and that the manifestation of deficiency of qi clinically showed proliferative lesion of glomerular mesangium, while the glomerular sclerosis pathologically showed the manifestation of yin deficiency. Conclusion： renal pathological findings may be a candidate of objective factors to refine CM syndrome typing process.

关键词： IgA nephropathy Chinese medicine renal pathology syndrome differentiation pattern diagnosis

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COVID-19 induced renal injury differs from that in other viral-infections

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Emergency and Critical Care Medicine 2022年第1期2卷 23-31页

作者： Rachel S.Parise Manoj Govindarajulu Sindhu Ramesh Tony Thomas Timothy Moore Muralikrishnan Dhanasekaran Department of Drug Discovery and Development Auburn University Harrison School of PharmacyWalker BuildingAuburnAlabamaUSA Department of Mechanical Engineering Auburn UniversityAuburnAlabamaUSA

Background:Kidney injuries caused by several viral diseases have been reported worldwide among all age groups,races,and genders.Of particular importance is coronavirus disease 2019(COVID-19),and its prevalence in communities infecting all patient populations with symptoms ranging from asymptomatic to severe,including complications and mortality.Methods:Data were acquired from PubMed,Scopus,Google Scholar,Centers for Disease Prevention and Control(CDC),and Lexi-Comp using the following search terms:“COVID-19 and renal pathology,”“COVID-19 induced kidney disease,”“Viral infection induced kidney disease,”and“Viral infection induced renal damage.”Titles and abstracts were manually analyzed as per the exclusion and inclusion criteria of relevant articles;relevance of articles included studies on the pathology of a specific viral infection and the impact of the virus on the adult renal system.Results:The mechanisms for renal disease due to COVID-19 include direct renal tubular injury,cytokine storm,inflammation,thrombosis vs.acute tubular necrosis,thrombotic events,and direct renal injury.Although some mechanisms behind renal dysfunction among the studied viral infections are similar,the prevalence rates of kidney injury or damage differ.This might be described by recommended prophylactic and therapeutic approaches that can alter the viral infection characteristics and possibly the impact a particular organ system.Conclusion:The patient population at risk was old in age and had a high body mass index.The mechanisms associated with renal dysfunction are similar,including direct renal injury through angiotensin converting enzyme 2(ACE2)entry,inflammation,and thrombosis.The renal pathology of coronaviruses that differs from that of other prevalent viral infections is the activation of cytokine storm,which causes elevations of a greater number and different kinds of cytokines than other viral infections.

关键词： COVID-19 Kidney damage renal damage renal pathology

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Clinicopathological Features of renal Amyloidosis: A Single-center Study on 47 Cases

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第1期35卷 48-53页

作者：罗长青张育安李贞琼王玉梅 Department of Nephrology Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Nephrology The Third People’s Hospital of Yunnan Province

The correlations between the clinicopathological features and the long-term outcomes of renal amyloidosis（RA） were analyzed with a view to develop strategies for improving diagnosis and prognosis of RA. We retrospectively reviewed the clinicopathological characteristics of 47 patients diagnosed with RA between 2004 and 2014 at the Wuhan Union Hospital. The data on the renal histology, clinical manifestations, and prognosis of RA patients were retrieved from the hospital records and characteristic patterns were identified. The histological changes in the kidneys were correlated with the clinical manifestations of RA. Additionally, most RA patients in this study had decreased serum levels of κ light chain and increased urine levels of κ and λ light chains as well as presence of M-protein in the urine and serum. Patients with early RA showed no specific pathognomonic symptoms. Bleeding associated with diagnostic renal biopsy was rare. We recommend that the routine work-up of patients aged over 40 years and presenting with non-diabetic nephropathy includes the non-invasive tests for the measurement of serum and urine levels of κ and λ light chains as well as protein electrophoresis tests for the presence of urinary and serum M-protein. Additionally, such patients should undergo renal biopsy screening with Cong-red staining to ensure early diagnosis of RA and improve their survival, since the risk of hemorrhage related to renal biopsy screening is low at early stages of RA.

关键词： renal amyloidosis renal pathology clinical feature

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Sublytic C5b-9 Induces IL-6 and TGF-β1 Production by Glomerular Mesangial Cells Through p300-Mediated C/EBPβ Acetylation

Sublytic C5b-9 Induces IL-6 and TGF-β1 Production by Glomer...

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第十六届中国科协年会——分13感染、免疫和疫苗论坛

作者： Jing ZHANG Yan LI Kai SHAN Lulu WANG Wen QIU Yanlai LU Dan ZHAO Gangqian ZHU Fengxia HE Yingwei WANG Department of Microbiology and Immunology Nanjing Medical University

关键词： transcription factor post-translational modification renal inflammation renal pathology

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Sublytic C5b-9 Induces IL-6 and TGF-β1 Production by Glomerular Mesangial Cells through p300-mediated C/EBPβAcetylation

Sublytic C5b-9 Induces IL-6 and TGF-β1 Production by Glomer...

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第九届全国免疫学学术大会

作者： Jing Zhang Yan Li Kai Shan Lulu Wang Wen Qiu Yanlai Lu Dan Zhao Gangqian Zhu Fengxia He Yingwei Wang Department of Immunology Nanjing Medical University

The increased production of IL-6 and TGF-β1 by glomerular mesangial cells(GMC)in rat Thy-1 nephritis(Thy-1N),a model of human mesangioproliferative glomerulonephritis(MsPGN),is accompanied by sublytic C5b-9 deposition,but the mechanism of IL-6 and TGF-β1 upregulation in rat GMC triggered by sublytic C5b-9 in this model has not been elucidated.In the present study,molecular biological methods,along with functional and histological studies were performed.We found that sublytic C5b-9(here,less than 5%LDH release from cells is regarded as a sublytic effect)could induce the production of IL-6 and TGF-β1 through upregulating p300 and C/EBPB expression in GMC.Besides,C/EBPB-enhanced IL-6 and TGF-pi gene activation and p300-mediated C/EBPB acetylation were involved in promoter activity of IL-6 and TGF-β1 in GMC attacked by sublytic C5b-9.In detail,the elements of C/EBPp binding to rat IL-6and TGF-β1 promoter and three acetylated sites of rat C/EBPp protein were first revealed.Furthermore,silencing p300or C/EBPβgene in rat kidney significantly reduced the production of IL-6 and TGF-β1 and renal lesions in Thy-1N rats.Together,these data implicate that mechanism of IL-6 and TGF-β1 production in renal tissue of Thy-1N rats is associated with sublytic C5b-9-upregulated p300 and p300-mediated C/EBPβacetylation as well as C/EBPP-activated IL-6 and TGF-β1 genes.

关键词： transcription factor post-translational modification renal inflammation renal pathology

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